INT74058

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 16
Speculated 14
Reported most in Abstract
Documents 260
Total Number 274
Disease Relevance 80.04
Pain Relevance 95.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 39
spinal cord 23
dorsal horn 20
neurons 17
nucleus 9
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 943 100.00 Very High Very High Very High
nMDA receptor 557 100.00 Very High Very High Very High
Rostral ventrolateral medulla 550 100.00 Very High Very High Very High
cytokine 393 100.00 Very High Very High Very High
Calcitonin gene-related peptide 350 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 163 100.00 Very High Very High Very High
depression 64 100.00 Very High Very High Very High
Glutamate receptor 39 100.00 Very High Very High Very High
spinal dorsal horn 28 100.00 Very High Very High Very High
Locus ceruleus 17 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1034 100.00 Very High Very High Very High
Death 802 100.00 Very High Very High Very High
Cough 360 100.00 Very High Very High Very High
Nociception 260 100.00 Very High Very High Very High
Depression 64 100.00 Very High Very High Very High
Cv General 3 Under Development 31 99.90 Very High Very High Very High
Drug Dependence 27 99.90 Very High Very High Very High
Ganglion Cysts 55 99.82 Very High Very High Very High
Frailty 559 99.72 Very High Very High Very High
Neuropathic Pain 176 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 4 h after formalin injection, neuronal NO synthase (nNOS) and c-Fos expression in spinal dorsal horn was examined with immunocytochemistry method.
Gene_expression (expression) of nNOS in dorsal horn
1) Confidence 0.78 Published 2010 Journal Neurosci Bull Section Body Doc Link 20502499 Disease Relevance 0.08 Pain Relevance 0
At 4 h after formalin injection, neuronal NO synthase (nNOS) and c-Fos expression in spinal dorsal horn was examined with immunocytochemistry method.
Gene_expression (expression) of neuronal NO synthase in dorsal horn
2) Confidence 0.78 Published 2010 Journal Neurosci Bull Section Body Doc Link 20502499 Disease Relevance 0.08 Pain Relevance 0
The expression of nNOS in the spinal dorsal horn of L5 segment was assayed using immunohistochemistry 24 h later.
Gene_expression (expression) of nNOS in dorsal horn
3) Confidence 0.78 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 17062944 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: To investigate the expression of neuronal nitric oxide synthase (nNOS) in spinal dorsal horn and the effect of intrathecal katemine on the expression of nNOS in the rats with formalin-induced pain.
Spec (investigate) Gene_expression (expression) of nNOS in spinal associated with pain, spinal dorsal horn, intrathecal and neuronal nitric oxide synthase
4) Confidence 0.78 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 17062944 Disease Relevance 0.17 Pain Relevance 0.39
Therefore, 7-NI decreased in butorphanol-induced physical dependence and nNOS expression.
Gene_expression (expression) of nNOS associated with physical dependence and butorphanol
5) Confidence 0.78 Published 2008 Journal Synapse Section Abstract Doc Link 18512210 Disease Relevance 0.33 Pain Relevance 1.50
In the present study, we examined the effect of application of the alpha2-adrenoceptor agonist, clonidine hydrochloride, on nNOS expression in the rat jejunal myenteric plexus after splanchinic ganglionectomy.
Gene_expression (expression) of nNOS associated with ganglionectomy, agonist and clonidine
6) Confidence 0.78 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.67
The nNOS expression and nNOS mRNA were detected by immunohistochemistry and in situ hybridization for nNOS mRNA, respectively.
Gene_expression (expression) of nNOS
7) Confidence 0.78 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.73
M2 muscarinic receptor of spinal cord mediated increase of nNOS expression in locus coeruleus during morphine withdrawal.
Gene_expression (expression) of nNOS in locus coeruleus associated with locus ceruleus, narcan, withdrawal, morphine and spinal cord
8) Confidence 0.78 Published 2002 Journal Acta Pharmacol. Sin. Section Title Doc Link 12147190 Disease Relevance 0 Pain Relevance 0.58
AIM: To investigate the effects of different muscarinic receptor (M) subtypes in the spinal cord on the scores of naloxone-precipitated morphine-withdrawal symptoms and the changes of nNOS expression in locus coeruleus (LC).
Gene_expression (expression) of nNOS in spinal cord associated with locus ceruleus, narcan, withdrawal, morphine and spinal cord
9) Confidence 0.78 Published 2002 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 12147190 Disease Relevance 0.10 Pain Relevance 0.48
Decreased expression of nNOS protein was confirmed by immunoblotting.
Gene_expression (expression) of nNOS protein
10) Confidence 0.78 Published 1998 Journal Neuroreport Section Abstract Doc Link 9507963 Disease Relevance 0.78 Pain Relevance 0.37
To assess the role of NO in nerve injury-induced tactile allodynia, we examined neuronal NO synthase (nNOS) expression in the spinal cord and dorsal root ganglia (DRG) of rats with tactile allodynia because of either tight ligation of the left fifth and sixth lumbar spinal nerves or streptozotocin-induced diabetic neuropathy.
Spec (examined) Gene_expression (expression) of nNOS in dorsal root ganglia associated with brush evoked pain, nervous system injury, diabetic neuropathy and spinal cord
11) Confidence 0.78 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.73 Pain Relevance 0.66
To assess the role of NO in nerve injury-induced tactile allodynia, we examined neuronal NO synthase (nNOS) expression in the spinal cord and dorsal root ganglia (DRG) of rats with tactile allodynia because of either tight ligation of the left fifth and sixth lumbar spinal nerves or streptozotocin-induced diabetic neuropathy.
Spec (examined) Gene_expression (expression) of neuronal NO synthase in dorsal root ganglia associated with brush evoked pain, nervous system injury, diabetic neuropathy and spinal cord
12) Confidence 0.78 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10531423 Disease Relevance 0.73 Pain Relevance 0.66
Moreover, moxibustion at ST36 suppressed the production of NO and the protein expression of c-Fos and nNOS induced by arthritis.
Gene_expression (expression) of nNOS associated with arthritis
13) Confidence 0.78 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437739 Disease Relevance 0.60 Pain Relevance 0.39
These results suggest that moxibustion at ST36 has a potent antinociceptive effect in an arthritic rat model, and modulates neuronal excitability and endogenous NO production by suppressing c-Fos and nNOS protein expression.
Gene_expression (expression) of nNOS protein in neuronal associated with neuronal excitability, antinociceptive and arthritis
14) Confidence 0.78 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437739 Disease Relevance 0.57 Pain Relevance 0.37
Western blot experiments demonstrated the expression of neuronal NO synthase (nNOS) in mesenteric artery from WKY rats; however, electrical field stimulation alone did not induce detectable NO release.
Gene_expression (expression) of neuronal NO synthase in neuronal
15) Confidence 0.77 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15033389 Disease Relevance 0 Pain Relevance 0.08
Western blot experiments demonstrated the expression of neuronal NO synthase (nNOS) in mesenteric artery from WKY rats; however, electrical field stimulation alone did not induce detectable NO release.
Gene_expression (expression) of nNOS in neuronal
16) Confidence 0.77 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15033389 Disease Relevance 0 Pain Relevance 0.08
To elucidate how glucocorticoids affect this mechanism, we studied the effects of intrathecal (it) injection of prednisolone acetate (PA) on a nociceptive stimulus and the changes of nNOS and NR2B subunit expression in the spinal dorsal horn of Sprague Dawley rats following chronic compression of the dorsal root ganglia (CCD).
Gene_expression (expression) of nNOS in spinal associated with nociception, spinal dorsal horn and intrathecal
17) Confidence 0.77 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.34 Pain Relevance 0.67
Effects of intrathecal injection of prednisolone acetate on expression of NR2B subunit and nNOS in spinal cord of rats after chronic compression of dorsal root ganglia.
Gene_expression (expression) of nNOS in spinal cord associated with spinal cord and intrathecal
18) Confidence 0.77 Published 2007 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 18000292 Disease Relevance 0.31 Pain Relevance 0.70
The results suggest that PA upregulation of neuronal nitric oxide synthase and NR2B subunit expression in the spinal dorsal horn contributes to PA inhibition of hyperalgesia induced by chronic compression of dorsal root ganglia.
Gene_expression (expression) of neuronal nitric oxide synthase in dorsal horn associated with hyperalgesia, spinal dorsal horn and neuronal nitric oxide synthase
19) Confidence 0.77 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.39 Pain Relevance 0.84
Based on these findings, we suggest that 5-HT(1B/1D) receptor has an important role in stabilizing the trigeminovascular system by attenuating the expression of nNOS enzyme, hence reducing nitric oxide production.
Gene_expression (expression) of nNOS
20) Confidence 0.77 Published 2003 Journal Cephalalgia Section Abstract Doc Link 14510930 Disease Relevance 0.15 Pain Relevance 0.47

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