INT74059

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 55
Total Number 61
Disease Relevance 11.50
Pain Relevance 21.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
dorsal horn 18
neuronal 10
spinal cord 9
TNC 8
gracile nucleus 8
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 309 100.00 Very High Very High Very High
Nerve growth factor 86 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 37 100.00 Very High Very High Very High
cva 8 100.00 Very High Very High Very High
Dorsal horn 238 99.98 Very High Very High Very High
agonist 81 99.98 Very High Very High Very High
ganglionectomy 7 99.96 Very High Very High Very High
Arthritis 26 99.84 Very High Very High Very High
Locus ceruleus 14 99.84 Very High Very High Very High
Sciatic nerve 39 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4 100.00 Very High Very High Very High
Arthritis 80 99.84 Very High Very High Very High
Stress 162 99.76 Very High Very High Very High
Targeted Disruption 80 99.74 Very High Very High Very High
Disease 34 99.26 Very High Very High Very High
Nociception 85 99.06 Very High Very High Very High
Interstitial Cystitis 2 98.16 Very High Very High Very High
Hyperalgesia 64 97.64 Very High Very High Very High
Opiate Addiction 2 97.08 Very High Very High Very High
Headache 13 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M2 muscarinic receptor of spinal cord mediated increase of nNOS expression in locus coeruleus during morphine withdrawal.
Positive_regulation (increase) of Gene_expression (expression) of nNOS in locus coeruleus associated with locus ceruleus, narcan, withdrawal, morphine and spinal cord
1) Confidence 0.70 Published 2002 Journal Acta Pharmacol. Sin. Section Title Doc Link 12147190 Disease Relevance 0 Pain Relevance 0.58
Moreover, moxibustion at ST36 suppressed the production of NO and the protein expression of c-Fos and nNOS induced by arthritis.
Positive_regulation (induced) of Gene_expression (expression) of nNOS associated with arthritis
2) Confidence 0.69 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437739 Disease Relevance 0.60 Pain Relevance 0.39
The results suggest that PA upregulation of neuronal nitric oxide synthase and NR2B subunit expression in the spinal dorsal horn contributes to PA inhibition of hyperalgesia induced by chronic compression of dorsal root ganglia.
Positive_regulation (upregulation) of Gene_expression (expression) of neuronal nitric oxide synthase in dorsal horn associated with hyperalgesia, spinal dorsal horn and neuronal nitric oxide synthase
3) Confidence 0.69 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.40 Pain Relevance 0.84
Increased neuronal nitric oxide synthase (nNOS) expression is reported to exist in morphine-tolerant animals.
Positive_regulation (Increased) of Gene_expression (expression) of nNOS in neuronal associated with morphine and neuronal nitric oxide synthase
4) Confidence 0.69 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12065191 Disease Relevance 0.19 Pain Relevance 0.43
In rats, 4 h after the systemic administration of NTG (10 mg/kg bw, s.c.), the neurons of the caudal trigeminal nucleus (TNC) are activated and the expression of neuronal NO synthase (nNOS) in the same area is increased suggesting a self-amplifying process in the trigeminal system, which seems to be crucial in migraine pathogenesis.
Positive_regulation (increased) of Gene_expression (expression) of nNOS in TNC associated with migraine
5) Confidence 0.69 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580819 Disease Relevance 0.26 Pain Relevance 0.21
The expression of the nNOS gene in the PVN was significantly increased 2 and 6 h after s.c. injection of formalin in comparison with that in untreated and saline injected rats.
Positive_regulation (increased) of Gene_expression (expression) of nNOS gene in PVN
6) Confidence 0.68 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474546 Disease Relevance 0.33 Pain Relevance 0.04
Finally, the expression of both NOS I and NOS II in the spinal cord as demonstrated by Western blots was increased by 20 min following intradermal capsaicin injection in the rat foot.
Positive_regulation (increased) of Gene_expression (expression) of NOS I in foot associated with qutenza and spinal cord
7) Confidence 0.63 Published 2001 Journal Pain Section Abstract Doc Link 11576744 Disease Relevance 0.14 Pain Relevance 1.00
In the rats treated with vehicle after the splanchinic ganglionectomy, nNOS expression in the myenteric plexus significantly increased compared with sham-operated rats.
Positive_regulation (increased) of Gene_expression (expression) of nNOS associated with ganglionectomy
8) Confidence 0.61 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.78
CONCLUSION: M2 muscarinic receptor of spinal cord mediated the increase of nNOS expression in LC during morphine withdrawal.


Positive_regulation (increase) of Gene_expression (expression) of nNOS in spinal cord
9) Confidence 0.61 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 12147190 Disease Relevance 0.07 Pain Relevance 0
The expression of nNOS positive neurons in the LC increased in morphine-dependent rats and increased to a greater extent during morphine withdrawal.
Positive_regulation (increased) of Gene_expression (expression) of nNOS in neurons
10) Confidence 0.61 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 12147190 Disease Relevance 0.08 Pain Relevance 0
Intrathecal injection of M2-AS inhibited the increase of nNOS expression in LC during morphine-withdrawal, but there was no effect in case of M1-AS.
Positive_regulation (increase) of Gene_expression (expression) of nNOS
11) Confidence 0.61 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 12147190 Disease Relevance 0.08 Pain Relevance 0
The expression of nNOS positive neurons in the LC increased in morphine-dependent rats and increased to a greater extent during morphine withdrawal.
Positive_regulation (increased) of Gene_expression (expression) of nNOS in neurons
12) Confidence 0.61 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 12147190 Disease Relevance 0.08 Pain Relevance 0
Acute restraint stress induced a significant increase in the density of neurons expressing NADPH-d and nNOS in the amygdaloid nuclei. nNOS expression increased also in the DG and piriform cortex.
Positive_regulation (increased) of Gene_expression (expression) of nNOS in piriform cortex
13) Confidence 0.60 Published 2004 Journal Neuroscience Section Body Doc Link 15120858 Disease Relevance 0 Pain Relevance 0
The results suggest that morphine tolerance affects NMDA receptor binding activity and increases nNOS expression in the rat spinal cord.
Positive_regulation (increases) of Gene_expression (expression) of nNOS in spinal cord associated with nmda receptor, tolerance, spinal cord and morphine
14) Confidence 0.57 Published 2000 Journal Br J Anaesth Section Abstract Doc Link 11064618 Disease Relevance 0 Pain Relevance 1.20
EA stimulation of hindlimb acupoints consistently induces nNOS expression in the gracile nucleus, and L-arginine-derived NO synthesis in the gracile nucleus mediates cardiovascular responses to EA ST36 (23,44).
Positive_regulation (induces) of Gene_expression (expression) of nNOS in gracile nucleus associated with electroacupuncture
15) Confidence 0.57 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442119 Disease Relevance 0.20 Pain Relevance 0.66
Hz) applied to the hindlimb acupuncture points (acupoints) Jinggu and Shugu (BL 64–65), which are cutaneously located, induces nNOS expression in the gracile nucleus (23).
Positive_regulation (induces) of Gene_expression (expression) of nNOS in gracile nucleus associated with acupuncture
16) Confidence 0.57 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442119 Disease Relevance 0.08 Pain Relevance 0.37
These studies support the previous findings that the gracile nucleus receives somatosympathetic afferent inputs and demonstrate an increase in nNOS expression in the gracile nucleus with an ipsilateral predominance induced by activation of afferent somatic cutaneous nerves.
Positive_regulation (increase) of Gene_expression (expression) of nNOS in gracile nucleus
17) Confidence 0.57 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442119 Disease Relevance 0.15 Pain Relevance 0.70
Sciatic nerve transection increases gluthatione antioxidant system activity and neuronal nitric oxide synthase expression in the spinal cord.
Positive_regulation (increases) of Gene_expression (expression) of neuronal nitric oxide synthase in spinal cord associated with sciatic nerve, spinal cord and neuronal nitric oxide synthase
18) Confidence 0.56 Published 2009 Journal Brain Res. Bull. Section Title Doc Link 19683561 Disease Relevance 0.40 Pain Relevance 0.73
In the ipsilateral dorsal horn nNOS expression increased by 216% (Figure 2a), and in the contralateral dorsal horn the increase in nNOS expression was 194%, the difference between the sides being not statistically significant (Figure 2b).
Positive_regulation (increase) of Gene_expression (expression) of nNOS in dorsal horn associated with dorsal horn
19) Confidence 0.55 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.18 Pain Relevance 0.16
Neither COX-2 nor iNOS mRNAs were observed in the mucosa before and 1 hr after acidification, while the gene expression of COX-1 and nNOS was constitutively detected in the mucosa and appeared to be slightly up-regulated after the acid stimulation.
Positive_regulation (up-regulated) of Gene_expression (expression) of nNOS
20) Confidence 0.53 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12353866 Disease Relevance 0 Pain Relevance 0.09

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