INT7408

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Context Info
Confidence 0.43
First Reported 1982
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 2.38
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FGFR3) cytoplasmic membrane-bounded vesicle (FGFR3) plasma membrane (FGFR3)
Anatomy Link Frequency
upper body 1
synaptic cleft 1
nerve 1
FGFR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 2 99.58 Very High Very High Very High
Morphine 4 99.22 Very High Very High Very High
cocaine 4 99.20 Very High Very High Very High
sSRI 3 98.98 Very High Very High Very High
adenocard 11 98.66 Very High Very High Very High
antidepressant 4 98.56 Very High Very High Very High
depression 61 97.28 Very High Very High Very High
Nicotine 4 94.00 High High
GABAergic 4 92.32 High High
antagonist 4 92.00 High High
Disease Link Frequency Relevance Heat
Depression 66 97.28 Very High Very High Very High
Myalgia 3 93.44 High High
Cognitive Disorder 5 89.84 High High
Abdominal Pain 1 89.68 High High
Mental Disorders 2 86.08 High High
Manic Depressive Disorder 9 85.00 Quite High
Schizophrenia 3 77.20 Quite High
Nicotine Addiction 4 75.00 Quite High
Paralysis 5 73.96 Quite High
Bordatella Infection 1 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The simulations are based on the postulate by Bowman [7] that twitch fade is due to the decreased amount of ACh released by the fourth stimulus as compared to that released by the first stimulus.
Negative_regulation (decreased) of ACh
1) Confidence 0.43 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.18 Pain Relevance 0.09
Preliminary investigations suggested that it might also inhibit nicotinic ACh receptors.
Spec (might) Negative_regulation (inhibit) of ACh
2) Confidence 0.42 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19070647 Disease Relevance 0.09 Pain Relevance 0.16
These findings suggest that the partial neuromuscular blockade, for the inhibitory action of adenosine to be apparent, has to take place either postsynaptically via the blockade of ACh receptors or presynaptically at the nerve endings through a decrease in the evoked output of the transmitter.
Negative_regulation (blockade) of ACh in nerve associated with adenocard
3) Confidence 0.41 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6280626 Disease Relevance 0.07 Pain Relevance 0.56
These observations suggest that the main action of borbotoxin-A is to block post-synaptic nicotinic ACh receptors.
Negative_regulation (block) of ACh
4) Confidence 0.41 Published 2002 Journal Toxicon Section Abstract Doc Link 11689235 Disease Relevance 0 Pain Relevance 0.07
Morphine stimulates opiate kappa receptors and depresses ACh release.
Negative_regulation (depresses) of ACh associated with opiate and morphine
5) Confidence 0.37 Published 1991 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 1957023 Disease Relevance 0.23 Pain Relevance 0.70
A history of antidepressant treatment with SSRIs in the depressed subjects seemed to mitigate this decrease in FGFs and FGF receptors, especially for FGF2, FGFR2 and FGFR3.
Negative_regulation (decrease) of FGFR3 associated with antidepressant and ssri
6) Confidence 0.34 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 1.07 Pain Relevance 0.84
The doses of vecuronium used in this study decrease the amount of ACh released by the fourth stimulus up to about 70% of the amount released by the first stimulus.
Negative_regulation (decrease) of ACh
7) Confidence 0.31 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.05 Pain Relevance 0.03
We have conducted the following study in an attempt to relate the clinically observed twitch fade, to the decrease in ACh that could account for the fade elicited by a train of four stimuli.
Negative_regulation (decrease) of ACh
8) Confidence 0.27 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.22 Pain Relevance 0.07
The model was expanded by assuming that the fourth stimulus releases either the same or a smaller number of ACh molecules, and establishes the initial concentration of ACh in the synaptic cleft denoted by [A]4.
Negative_regulation (number) of ACh in synaptic cleft
9) Confidence 0.27 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.06 Pain Relevance 0.03
The amount of ACh released by the TANs decreases in the presence of a stimulus [10].
Negative_regulation (decreases) of ACh
10) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.23
This auto-antagonism of ACh could be reversed by atropine.
Negative_regulation (reversed) of ACh
11) Confidence 0.08 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC493267 Disease Relevance 0 Pain Relevance 0.31
Continued hCGRP perifusion caused subsequent inhibition of ACh and gastrin release that was substantially greater in duration and magnitude than the initial stimulatory responses.
Negative_regulation (inhibition) of ACh
12) Confidence 0.07 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1348908 Disease Relevance 0.07 Pain Relevance 0.24
Lower and upper body maximal strength and explosive power were significantly (p < or = 0.05) decreased at EX-2 and EX-3 (approximately 10%).
Negative_regulation (decreased) of EX-3 in upper body
13) Confidence 0.01 Published 2003 Journal J Strength Cond Res Section Abstract Doc Link 14636105 Disease Relevance 0.33 Pain Relevance 0

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