INT7409

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Context Info
Confidence 0.37
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.24
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FGFR3) cytoplasmic membrane-bounded vesicle (FGFR3) plasma membrane (FGFR3)
Anatomy Link Frequency
cholinergic neurons 2
interneurons 2
FGFR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 2 99.98 Very High Very High Very High
cocaine 4 99.42 Very High Very High Very High
GABAergic 8 97.96 Very High Very High Very High
Inflammation 115 97.86 Very High Very High Very High
projection neuron 20 97.00 Very High Very High Very High
opiate 2 96.80 Very High Very High Very High
Morphine 4 96.08 Very High Very High Very High
Serotonin 3 93.92 High High
Thalamus 4 93.64 High High
Substantia nigra 2 92.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 112 97.86 Very High Very High Very High
Depression 64 92.36 High High
Inflammatory Bowel Disease 96 89.40 High High
Obesity 7 88.88 High High
Colitis 60 80.00 Quite High
Nicotine Addiction 4 75.00 Quite High
Bordatella Infection 1 68.56 Quite High
Disease 43 64.12 Quite High
Neurodegenerative Disease 13 61.44 Quite High
Paralysis 7 60.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The correlation between the clinically observed fade and the simulated decrease in [A]4/[A]1 allowed us to suggest tentative estimates for the vecuronium-induced decrease of ACh release elicited by the fourth stimulus during the TOF pattern of stimulation.
Negative_regulation (decrease) of Localization (release) of ACh
1) Confidence 0.37 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.05 Pain Relevance 0.03
The primary purpose of the present study was to correlate twitch fade, as observed in the current study and by the other investigators, with the decrease in ACh release that would be necessary to produce the fade.
Negative_regulation (decrease) of Localization (release) of ACh
2) Confidence 0.37 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.20 Pain Relevance 0.10
Cocaine blocks Ca2+ influx and thus blocks ACh release.
Negative_regulation (blocks) of Localization (release) of ACh associated with cocaine
3) Confidence 0.32 Published 1991 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 1957023 Disease Relevance 0.28 Pain Relevance 0.71
The doses of vecuronium used in this study decrease the amount of ACh released by the fourth stimulus up to about 70% of the amount released by the first stimulus.
Negative_regulation (decrease) of Localization (released) of ACh
4) Confidence 0.31 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.05 Pain Relevance 0.03
The simulations are based on the postulate by Bowman [7] that twitch fade is due to the decreased amount of ACh released by the fourth stimulus as compared to that released by the first stimulus.
Negative_regulation (decreased) of Localization (released) of ACh
5) Confidence 0.31 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.18 Pain Relevance 0.09
The number of ACh molecules released by the first stimulus was postulated to establish a constant initial concentration of ACh, [A]1 = 7.75 × 10-6 M.
Negative_regulation (number) of Localization (released) of ACh
6) Confidence 0.27 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.07 Pain Relevance 0.03
On the other hand, the decrease in T4 is caused by a combination of increased postsynaptic receptor occupancy and the diminished release of ACh elicited by the fourth stimulus.
Negative_regulation (diminished) of Localization (release) of ACh
7) Confidence 0.27 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0
In the second part, we expanded our model of neuromuscular transmission[11] by considering a decrease in the release of ACh elicited by the fourth stimulus.


Negative_regulation (decrease) of Localization (release) of ACh
8) Confidence 0.27 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.24 Pain Relevance 0.29
The amount of ACh released by the TANs decreases in the presence of a stimulus [10].
Negative_regulation (decreases) of Localization (released) of ACh
9) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0 Pain Relevance 0.23
Continued hCGRP perifusion caused subsequent inhibition of ACh and gastrin release that was substantially greater in duration and magnitude than the initial stimulatory responses.
Negative_regulation (inhibition) of Localization (release) of ACh
10) Confidence 0.10 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1348908 Disease Relevance 0.07 Pain Relevance 0.25
In the striatum, dopamine inhibits ACh release from the cholinergic interneurons in vivo and in vitro [10], [18]–[22].
Negative_regulation (inhibits) of Localization (release) of ACh in interneurons associated with dopamine
11) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0.17 Pain Relevance 0.46
In the rodent intestine, inflammation markedly affects the cholinergic neurons that comprise the major excitatory phenotype of the ENS, causing decreased release of ACh [40].
Negative_regulation (decreased) of Localization (release) of ACh in cholinergic neurons associated with inflammation
12) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 0.92 Pain Relevance 0.71

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