INT74097

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Context Info
Confidence 0.52
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.89
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ep300) transferase activity, transferring acyl groups (Ep300) DNA binding (Ep300)
transcription factor binding (Ep300) cytoplasm (Ep300)
Anatomy Link Frequency
superior 1
Ep300 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 7 89.48 High High
phantom limb 6 89.28 High High
Morphine 9 88.44 High High
Opioid 3 83.36 Quite High
depression 75 64.84 Quite High
antidepressant 3 58.56 Quite High
imagery 21 44.00 Quite Low
Paracetamol 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 102 99.44 Very High Very High Very High
Cognitive Disorder 8 95.16 Very High Very High Very High
Anxiety Disorder 54 91.28 High High
Pain 6 89.48 High High
Conversion Disorder 1 88.16 High High
Shock 12 85.64 High High
Disease 15 75.68 Quite High
Paralysis 30 69.64 Quite High
Fasciculation 3 68.00 Quite High
Depression 90 64.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P300 was present with this paradigm stimulating the healthy left hand, as well as in a 'malingerer' - a healthy subject who was instructed to feign the same deficit.
Gene_expression (present) of P300
1) Confidence 0.52 Published 1998 Journal Neuroreport Section Abstract Doc Link 9507953 Disease Relevance 0.27 Pain Relevance 0
Thus, like CBP, p300 or TRAP220, NCoA6 appears to be an essential gene involved in the regulation of growth, development and cell survival.
Gene_expression (appears) of p300
2) Confidence 0.22 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
CBP/p300
Gene_expression (/) of p300
3) Confidence 0.22 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.09 Pain Relevance 0
p300 could not be detected in the same Western blot, suggesting that NCoA6(NRC) might preferentially associate with CBP in vivo [Mahajan and Samuels, 2000].
Neg (not) Gene_expression (detected) of p300
4) Confidence 0.22 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.06 Pain Relevance 0
Thus, liganded NRs bind members of the p160 family, which recruit CBP/p300 (and CBP bound p/CAF) to a target gene promoter.
Gene_expression (/) of p300
5) Confidence 0.22 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Therefore, for quick and reliable communication a P300-BCI is the BCI of choice provided a P300 is detectable.
Gene_expression (detectable) of P300
6) Confidence 0.03 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2916671 Disease Relevance 0.23 Pain Relevance 0.03
Taken together, we conclude that the P300-BCI is superior to the SMR-BCI for healthy persons and ALS patients alike, provided a P300 is detectable and vision is intact.
Gene_expression (detectable) of P300 in superior associated with motor neuron diseases
7) Confidence 0.03 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2916671 Disease Relevance 0.74 Pain Relevance 0.35
An eighth participant (H) was confronted with the P300-BCI, but because a reliable P300 could not be detected, was not included in the study.
Neg (not) Gene_expression (detected) of P300
8) Confidence 0.03 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2916671 Disease Relevance 0.50 Pain Relevance 0.35

General Comments

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