INT74098

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 16.25
Pain Relevance 14.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
dorsal horn 6
neurons 6
spinal cord 4
nucleus 4
motoneurons 4
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 42 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 22 100.00 Very High Very High Very High
butorphanol 14 100.00 Very High Very High Very High
depression 13 100.00 Very High Very High Very High
Physical dependence 5 100.00 Very High Very High Very High
Dorsal horn 161 99.98 Very High Very High Very High
ketamine 114 99.98 Very High Very High Very High
Morphine 82 99.98 Very High Very High Very High
tetrodotoxin 2 99.70 Very High Very High Very High
Spinal cord 171 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 15 100.00 Very High Very High Very High
Depression 13 100.00 Very High Very High Very High
Injury 116 99.76 Very High Very High Very High
Myocardial Infarction 6 99.72 Very High Very High Very High
Chronic Renal Failure 37 99.66 Very High Very High Very High
Arthritis 66 99.52 Very High Very High Very High
Diabetes Mellitus 21 99.08 Very High Very High Very High
Frailty 15 99.04 Very High Very High Very High
Death 164 98.96 Very High Very High Very High
Brain Hemorrhage 22 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, 7-NI decreased in butorphanol-induced physical dependence and nNOS expression.
Negative_regulation (decreased) of Gene_expression (expression) of nNOS associated with physical dependence and butorphanol
1) Confidence 0.59 Published 2008 Journal Synapse Section Abstract Doc Link 18512210 Disease Relevance 0.33 Pain Relevance 1.53
Decreased expression of nNOS protein was confirmed by immunoblotting.
Negative_regulation (Decreased) of Gene_expression (expression) of nNOS protein
2) Confidence 0.59 Published 1998 Journal Neuroreport Section Abstract Doc Link 9507963 Disease Relevance 0.78 Pain Relevance 0.38
Moreover, moxibustion at ST36 suppressed the production of NO and the protein expression of c-Fos and nNOS induced by arthritis.
Negative_regulation (suppressed) of Gene_expression (expression) of nNOS associated with arthritis
3) Confidence 0.58 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437739 Disease Relevance 0.60 Pain Relevance 0.39
These novel observations suggest that early blockade of TNF-alpha and nNOS expression within 20-30 min after SCI is beneficial in nature.
Negative_regulation (blockade) of Gene_expression (expression) of nNOS associated with frailty
4) Confidence 0.57 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20633123 Disease Relevance 0.99 Pain Relevance 0.30
By contrast, pretreatment with lysine acetylsalicylate (50 mg/kg i.m.) attenuates the NTG-induced nNOS expression in the superficial laminae of trigeminal nucleus caudalis.
Negative_regulation (attenuates) of Gene_expression (expression) of nNOS in nucleus
5) Confidence 0.51 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15154853 Disease Relevance 0 Pain Relevance 0.33
Insulin treatment completely prevented decreases in withdrawal threshold and nNOS expression.
Negative_regulation (prevented) of Gene_expression (expression) of nNOS associated with withdrawal
6) Confidence 0.51 Published 1998 Journal Neuroreport Section Abstract Doc Link 9507963 Disease Relevance 0.76 Pain Relevance 0.38
Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).
Negative_regulation (decreases) of Gene_expression (expression) of nNOS associated with depression and morphine
7) Confidence 0.50 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.94
In addition, prenatal morphine exposure reduced not only the expression of nNOS and the phosphorylation of cAMP responsive element-binding protein at serine 133 (CREB(Serine-133)), but also the magnitude of long-term depression (LTD) at P14.
Negative_regulation (reduced) of Gene_expression (expression) of nNOS associated with depression and morphine
8) Confidence 0.50 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.25 Pain Relevance 1.12
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Negative_regulation (inhibition) of Gene_expression (expression) of nNOS in motoneurons
9) Confidence 0.47 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
In contrast, CNTF and IGF-1 were ineffective in either inhibiting nNOS expression or preventing motoneuron death.
Negative_regulation (inhibiting) of Gene_expression (expression) of nNOS in motoneuron associated with death
10) Confidence 0.47 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.36 Pain Relevance 0.04
In the ipsilateral (right) dorsal horn nNOS expression decreased by 73% and 77% at 6 and 24 hours after the administration of CPP, respectively, whereas in the contralateral (left) dorsal horn nNOS decreased by 73% and 75% during the same periods (Figure 3a).
Negative_regulation (decreased) of Gene_expression (expression) of nNOS in dorsal horn associated with dorsal horn
11) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.14 Pain Relevance 0.63
Intrathecal administration of CPP and ketamine decreased nNOS expression in monoarthritic rats.
Negative_regulation (decreased) of Gene_expression (expression) of nNOS associated with ketamine and intrathecal
12) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.15 Pain Relevance 0.61
There was no difference in acute phase of formalin test among the 3 groups, while in tonic phase, the licking and biting time, and the protein levels of nNOS and c-Fos in spinal dorsal horn were significantly decreased in low dose group and increased in high dose group, compared with those in control group.
Negative_regulation (decreased) of Gene_expression (levels) of nNOS in dorsal horn
13) Confidence 0.43 Published 2010 Journal Neurosci Bull Section Body Doc Link 20502499 Disease Relevance 0.07 Pain Relevance 0
These results suggest that moxibustion at ST36 has a potent antinociceptive effect in an arthritic rat model, and modulates neuronal excitability and endogenous NO production by suppressing c-Fos and nNOS protein expression.
Negative_regulation (suppressing) of Gene_expression (expression) of nNOS protein in neuronal associated with neuronal excitability, antinociceptive and arthritis
14) Confidence 0.43 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437739 Disease Relevance 0.57 Pain Relevance 0.37
Based on these findings, we suggest that 5-HT(1B/1D) receptor has an important role in stabilizing the trigeminovascular system by attenuating the expression of nNOS enzyme, hence reducing nitric oxide production.
Negative_regulation (attenuating) of Gene_expression (expression) of nNOS
15) Confidence 0.42 Published 2003 Journal Cephalalgia Section Abstract Doc Link 14510930 Disease Relevance 0.15 Pain Relevance 0.48
One week of tetrodotoxin significantly decreased the expression of NMDAR1, nNOS, and CO activity.
Negative_regulation (decreased) of Gene_expression (expression) of nNOS associated with tetrodotoxin
16) Confidence 0.40 Published 1999 Journal J. Neurocytol. Section Abstract Doc Link 10800203 Disease Relevance 0 Pain Relevance 0.37
Intrathecal administration of the NMDA receptor antagonists CPP and ketamine rapidly decreased nNOS expression in the spinal cord of monoarthritic rats and increased the expression of eNOS and iNOS.
Negative_regulation (decreased) of Gene_expression (expression) of nNOS in spinal cord associated with nmda receptor antagonist, ketamine, spinal cord and intrathecal
17) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.31 Pain Relevance 0.71
In this regard, it is tempting to speculate that the decrease in nNOS expression induced by the intrathecal administration of CPP or ketamine could be related to the depressant action of these drugs on the activity of pain-transmitting dorsal horn neurons, but there are no conclusive data on this matter.
Negative_regulation (decrease) of Gene_expression (expression) of nNOS in dorsal horn associated with pain, ketamine, dorsal horn neuron and intrathecal
18) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.57 Pain Relevance 0.71
They could attenuate endothelial, inducible, and neuronal nitric oxide synthase and cyclooxygenase-1 and -2 gene expression after MI.
Negative_regulation (attenuate) of Gene_expression (expression) of neuronal nitric oxide synthase in neuronal associated with myocardial infarction and neuronal nitric oxide synthase
19) Confidence 0.38 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16172162 Disease Relevance 0.39 Pain Relevance 0.95
Sumatriptan pretreatment also attenuated the NTG-evoked expression of nNOS in all studied areas.
Negative_regulation (attenuated) of Gene_expression (expression) of nNOS associated with sumatriptan
20) Confidence 0.37 Published 2003 Journal Cephalalgia Section Abstract Doc Link 14510930 Disease Relevance 0.17 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox