INT741

Context Info Confidence 0.49 First Reported 1979 Last Reported 2011 Negated 1 Speculated 2 Reported most in Abstract Documents 159 Total Number 161 Disease Relevance 62.43 Pain Relevance 35.93

Anatomy Mention Frequency urine 3 plasma 3 tube 3 platelets 2 BBM 2 phosphatase (Caenorhabditis elegans)

Pain Term Frequency Confidence Heat Pain 203 100.00 qutenza 499 99.92 Potency 8 99.88 Paracetamol 116 99.84 aspirin 21 99.84 cINOD 116 99.74 Spinal cord 187 99.60 halothane 8 99.56 central sensitization 230 99.52 substantia gelatinosa 1 99.32

Disease Term Frequency Confidence Heat Tendon Injuries 3 100.00 Pain 188 100.00 Hypophosphatemia 3 99.96 Hypothermia 12 99.96 Cancer 297 99.92 Obesity 41 99.92 Overactive Bladder 1 99.90 Toxicity 69 99.84 Body Weight 28 99.72 Osteoporosis 281 99.70

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

7 patients with Paget's disease were treated with synthetic human calcitonin over 6 months. 6 patients responded favourably to treatment and showed a marked decrease in serum alkaline phosphatase and urinary hydroxyproline.

Negative_regulation (decrease) of phosphatase associated with disease

1) Confidence 0.49 Published 1980 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 6933743 Disease Relevance 0.26 Pain Relevance 0.09

Articular chondrocalcinosis was observed in both cases, as was a decrease in alkaline phosphatase and the increased urinary excretion of phosphoethanolamine.

Negative_regulation (decrease) of phosphatase in Articular associated with chondrocalcinosis

2) Confidence 0.49 Published 1985 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 3992153 Disease Relevance 0.63 Pain Relevance 0.10

Objectively, a significant decrease in plasma alkaline phosphatase activity and in urinary hydroxyproline excretion was observed.

Negative_regulation (decrease) of phosphatase in plasma

3) Confidence 0.49 Published 1985 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 3922124 Disease Relevance 0.36 Pain Relevance 0.10

Decreasing levels of bilirubin , alkaline phosphatase and gamma-GT are of minor value in diagnosing a stone passage.

Negative_regulation (Decreasing) of phosphatase

4) Confidence 0.49 Published 1986 Journal Ultraschall Med Section Abstract Doc Link 3529380 Disease Relevance 0.27 Pain Relevance 0.22

Urinary excretion of hydroxyproline fell to 39 and 42% of pretreatment values (oral and IV treatments respectively), and was followed by a similar decrease in the serum activity of alkaline phosphatase.

Negative_regulation (decrease) of phosphatase

5) Confidence 0.49 Published 1987 Journal J. Bone Miner. Res. Section Abstract Doc Link 3455614 Disease Relevance 0.70 Pain Relevance 0.18

Serum glucose, cortisone and serum alkaline phosphatase levels increased significantly after tendon injury repair in all the animals and decreased slowly at all subsequent intervals in control group, whereas, it was near normal in the treatment group on day 30 post-tenorrhaphy.

Negative_regulation (decreased) of phosphatase in tendon associated with tendon injuries

6) Confidence 0.49 Published 2006 Journal J Vet Med A Physiol Pathol Clin Med Section Abstract Doc Link 16737515 Disease Relevance 0.73 Pain Relevance 0.22

Elevated serum alkaline phosphatase and urine hydroxyproline values were reduced by the treatment, demonstrating drug activity at the lesional level.

Negative_regulation (reduced) of phosphatase in urine

7) Confidence 0.49 Published 2000 Journal Acta Paediatr. Section Abstract Doc Link 10709889 Disease Relevance 0.81 Pain Relevance 0.19

This marked improvement was correlated with a decline in serum acid phosphatase, disappearance of soft tissue tumor, and clinical improvement in the patient.

Negative_regulation (decline) of phosphatase associated with cancer

8) Confidence 0.49 Published 1981 Journal Urology Section Abstract Doc Link 7222327 Disease Relevance 0.44 Pain Relevance 0

In four of the seven responding patients the reduction in liver size was durable (4-28 months) and was associated with a decrease in serum alkaline phosphatase levels.

Negative_regulation (decrease) of phosphatase in liver

9) Confidence 0.49 Published 1997 Journal Br. J. Haematol. Section Abstract Doc Link 9375753 Disease Relevance 1.32 Pain Relevance 0.11

Hypophosphatasia is a hereditary disorder characterized by a deficiency of liver/bone/kidney alkaline phosphatase activity in serum and tissues with defective bone mineralization, bone deformities, short stature, early loss of teeth, and craniosynostosis.

Negative_regulation (deficiency) of phosphatase in teeth associated with phosphate metabolism disorders, craniosynostosis, congenital anomalies and growth problems

10) Confidence 0.49 Published 1991 Journal Z Rheumatol Section Abstract Doc Link 1796658 Disease Relevance 1.54 Pain Relevance 0.12

It has therefore been suggested that the observed depletion of specific macromolecules, including sensory peptides, specific glycoconjugates and sensory neurone specific acid phosphatase, may be accounted for, at least in part, by an irreversible loss of sensory ganglion neurones.

Negative_regulation (depletion) of phosphatase in sensory ganglion associated with ganglion cysts

11) Confidence 0.49 Published 1992 Journal Exp. Physiol. Section Abstract Doc Link 1321641 Disease Relevance 0.35 Pain Relevance 0.74

During the zinc-free period (3-7) a marked decrease in serum zinc and serum alkaline phosphatase values was noted in the two children with AE and they showed clinical evidence of zinc deficiency (angular stomatitis, scaling around finger nails, and irritability).

Negative_regulation (decrease) of phosphatase in angular associated with stomatitis

12) Confidence 0.49 Published 1979 Journal Br. J. Dermatol. Section Abstract Doc Link 117822 Disease Relevance 0.24 Pain Relevance 0.08

Clinical response was associated with a decrease in plasma alkaline phosphatase.

Negative_regulation (decrease) of phosphatase in plasma

13) Confidence 0.49 Published 1979 Journal Cancer Treat Rep Section Abstract Doc Link 93511 Disease Relevance 0.78 Pain Relevance 0.34

Both groups treated with 20 and 10 mg/kg showed a highly significant decrease of urinary hydroxyproline (THP) excretion and of serum alkaline phosphatase (P less than 0.01) after two and six months of treatment although the trend comparison between doses was not significant.

Negative_regulation (decrease) of phosphatase

14) Confidence 0.49 Published 1979 Journal Am. J. Med. Sci. Section Abstract Doc Link 106728 Disease Relevance 0.49 Pain Relevance 0.09

Laboratory data revealed a high serum alkali phosphatase level of 820 mU/ml(at 3 months), which gradually decreased to 274 mU/ml with pain relief at 11 months after the beginning of this chemotherapy.

Negative_regulation (decreased) of phosphatase associated with pain

15) Confidence 0.36 Published 1989 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 2496670 Disease Relevance 0.53 Pain Relevance 0.10

Total alkaline phosphatase activity was reduced at 18 h and increased at 14 days by condylotomy, with no differences at the intermediate time intervals; similarly 45Ca-uptake was increased at the 14-day interval.

Negative_regulation (reduced) of phosphatase

16) Confidence 0.36 Published 1989 Journal Arch. Oral Biol. Section Abstract Doc Link 2610626 Disease Relevance 0.08 Pain Relevance 0.08

Mean (+/-SD) serum alkaline phosphatase at diagnosis was 1514 +/- 1168 IU/L and nine months after treatment with bisphosphonates decreased to 454 +/- 406 IU/ L(P<0.03).

Negative_regulation (decreased) of phosphatase

17) Confidence 0.36 Published 2006 Journal J Assoc Physicians India Section Body Doc Link 17089900 Disease Relevance 0.07 Pain Relevance 0

There are a number of therapeutic choices of sometimes surprising, sometimes disappointing efficacy, especially in cases "escaping" oestrogen control, heralded by a rise in phosphatase levels.

Negative_regulation (rise) of phosphatase

18) Confidence 0.35 Published 1983 Journal Rev Med Interne Section Abstract Doc Link 6665342 Disease Relevance 0.52 Pain Relevance 0.09

H-8, a protein kinase G inhibitor, and okadaic acid, a protein phosphatase inhibitor, when administered 30 min after prostaglandin E2, or 180 min after prostaglandin E2 plus rolipram, produced no significant effect.

Negative_regulation (inhibitor) of phosphatase

19) Confidence 0.17 Published 1995 Journal Neuroscience Section Abstract Doc Link 7715785 Disease Relevance 0.63 Pain Relevance 0.48

Many experience a decrease in the size of the primary tumor, a decrease in the levels of serum acid phosphatase, relief of bone pain, a decrease in bladder outlet obstruction, an increase in appetite, and a generalized improvement in their overall sense of well-being.

Negative_regulation (decrease) of phosphatase in bladder associated with pain and cancer

20) Confidence 0.17 Published 1984 Journal Urology Section Abstract Doc Link 6388092 Disease Relevance 0.44 Pain Relevance 0.10

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