INT7412

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 71
Total Number 73
Disease Relevance 24.44
Pain Relevance 29.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
plasma 10
pituitary 3
neurons 2
outflow 1
Pfeiffer 1
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 763 100.00 Very High Very High Very High
substance P 41 100.00 Very High Very High Very High
Enkephalin 35 100.00 Very High Very High Very High
Opioid 16 100.00 Very High Very High Very High
rheumatoid arthritis 13 100.00 Very High Very High Very High
Calcitonin gene-related peptide 13 100.00 Very High Very High Very High
Cholecystokinin 6 100.00 Very High Very High Very High
cytokine 6 99.80 Very High Very High Very High
agonist 125 99.76 Very High Very High Very High
Neuropeptide 41 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 13 100.00 Very High Very High Very High
Sepsis 8 99.98 Very High Very High Very High
Prolactinoma 94 99.92 Very High Very High Very High
Pancreatic Cancer 25 99.92 Very High Very High Very High
Hypoglycemia 29 99.80 Very High Very High Very High
Carcinoid 103 99.72 Very High Very High Very High
Pancreatitis 25 99.64 Very High Very High Very High
Cancer 600 99.54 Very High Very High Very High
Obesity 24 99.54 Very High Very High Very High
Metastasis 103 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Abdominal surgical operationsinduced a significant increase of SST-LI in the serum. 2 h later it was restored in the cases of laparoscopic interventions but still remained elevated after hernia surgeries.
Positive_regulation (increase) of SST
1) Confidence 0.70 Published 2008 Journal Neuroimmunomodulation Section Body Doc Link 18716415 Disease Relevance 0 Pain Relevance 0
The activity of somatostatin is mediated via binding to specific cell surface receptors.
Positive_regulation (mediated) of somatostatin associated with somatostatin
2) Confidence 0.70 Published 2001 Journal Trop. Med. Int. Health Section Abstract Doc Link 11737838 Disease Relevance 0.87 Pain Relevance 0.44
The last phenomenon has been explained by an increase of somatostatin (being a natural TSH inhibitor) in the patients on rhGH therapy [15].
Positive_regulation (increase) of somatostatin associated with somatostatin
3) Confidence 0.67 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.27 Pain Relevance 0.05
These suppressive actions may be achieved by activation of the somatostatin neurons in the Pe.
Positive_regulation (activation) of somatostatin in neurons associated with somatostatin
4) Confidence 0.67 Published 1988 Journal Endocrinology Section Abstract Doc Link 3123202 Disease Relevance 0 Pain Relevance 0.25
Increased concentrations of somatostatin, produced by pancreatic D cells or by intestinal mucosa, inihibit secretion of a number of GIT hormones, endocrine and exocrine pancreatic secretion.
Positive_regulation (Increased) of somatostatin in pancreatic D cells associated with somatostatin
5) Confidence 0.67 Published 2007 Journal Rozhl Chir Section Abstract Doc Link 18303777 Disease Relevance 1.11 Pain Relevance 0.17
Many animal experimental data show that activation of sst receptors leads to a reduction of pain behaviour.
Positive_regulation (activation) of sst associated with pain
6) Confidence 0.67 Published 2008 Journal Schmerz Section Abstract Doc Link 18278522 Disease Relevance 0.43 Pain Relevance 0.60
Ingestion of all three basic nutrients--fat, carbohydrate, and particularly protein--elicits a significant increase in peripheral vein plasma somatostatin levels in dogs and humans.
Positive_regulation (increase) of somatostatin in plasma associated with somatostatin
7) Confidence 0.65 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2876504 Disease Relevance 0 Pain Relevance 0.46
CONCLUSIONS: In this human study we showed for the first time that surgical interventions elevate the endogenous SST-LI in human serum.
Positive_regulation (elevate) of SST
8) Confidence 0.61 Published 2008 Journal Neuroimmunomodulation Section Body Doc Link 18716415 Disease Relevance 0 Pain Relevance 0
In Huntington's disease, there are reduced concentrations of substance P, met-enkephalin and cholecystokinin in the basal ganglia; in contrast the concentrations of somatostatin and TRH are increased.
Positive_regulation (increased) of somatostatin in basal ganglia associated with somatostatin, enkephalin, disease, cholecystokinin and substance p
9) Confidence 0.58 Published 1984 Journal Peptides Section Abstract Doc Link 6207511 Disease Relevance 0.51 Pain Relevance 0.48
Surgery and sepsis increase somatostatin-like immunoreactivity in the human plasma.
Spec (like) Positive_regulation (increase) of somatostatin in plasma associated with somatostatin and sepsis
10) Confidence 0.50 Published 2010 Journal Peptides Section Title Doc Link 20307604 Disease Relevance 0.46 Pain Relevance 0.47
On the 14th day of the treatment, pleural effusion and pseudocyst in the pancreatic head were additionally diagnosed based on the findings of computed tomography, magnetic resonance imaging and other examinations, and the dose of somatostatin analogue was increased to 200 microg/day.
Positive_regulation (increased) of somatostatin in head associated with pleural effusion, somatostatin and imagery
11) Confidence 0.50 Published 2005 Journal Kurume Med J Section Abstract Doc Link 16639988 Disease Relevance 0.50 Pain Relevance 0.42
Although it seems a paradox to treat patients with symptoms related to elevated SST levels with a somatostatinoma, in 1998 Angeletti et al showed that octreotide treatment was effective in reducing plasma levels of somatostatin and improving the related symptoms in three patients with metastatic somatostatinomas [48].
Positive_regulation (elevated) of SST in plasma associated with somatostatin and somatostatinoma
12) Confidence 0.50 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.38 Pain Relevance 0.27
Fifteen centres did not use Somatostatin as a routine after pancreatic surgery.
Neg (not) Positive_regulation (use) of Somatostatin associated with somatostatin
13) Confidence 0.49 Published 2009 Journal Trials Section Body Doc Link PMC2726965 Disease Relevance 0.05 Pain Relevance 0.29
Glucocorticoids are thought to inhibit growth hormone (GH) secretion through an enhancement of endogenous somatostatin tone.
Positive_regulation (enhancement) of somatostatin associated with somatostatin
14) Confidence 0.49 Published 1992 Journal Horm. Metab. Res. Section Abstract Doc Link 1398465 Disease Relevance 0.08 Pain Relevance 0.32
Reduced somatostatin levels in older RA patients resulted in a skewed upward growth hormone to somatostatin ratio.
Positive_regulation (resulted) of somatostatin associated with rheumatoid arthritis and somatostatin
15) Confidence 0.49 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 14977577 Disease Relevance 0.88 Pain Relevance 0.82
In the patients with diabetes secondary to chronic pancreatitis compared with Type I diabetics and normal controls, the pancreatic polypeptide concentrations were significantly lower and somatostatin concentrations were significantly higher after glucagon, arginine and a mixed meal.
Positive_regulation (concentrations) of somatostatin associated with diabetes mellitus, somatostatin and chronic pancreatitis
16) Confidence 0.49 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2899369 Disease Relevance 1.02 Pain Relevance 0.60
Cysteamine is formed by degradation of coenzyme A (CoA) and causes somatostatin (SS), prolactin and noradrenaline depletion in the brain and peripheral tissues. 2.
Positive_regulation (causes) of somatostatin in brain associated with noradrenaline and somatostatin
17) Confidence 0.49 Published 1990 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 2277850 Disease Relevance 0.45 Pain Relevance 0.44
Aim of our study was to investigate the effect of clonidine and galanin (alone or in combination) on growth hormone (GH) secretion in normal subjects and in adult patients with increased somatostatin tone due to chronic daily immunosuppressive glucocorticoid treatment.
Positive_regulation (increased) of somatostatin associated with somatostatin and clonidine
18) Confidence 0.49 Published 1994 Journal Endocr. Res. Section Abstract Doc Link 7519979 Disease Relevance 0.08 Pain Relevance 0.34
The absence of any either synergistic or at least additive effect on GH secretion of galanin and clonidine in conditions of both normal and increased somatostatin tone suggests that also in man, as well as in the rat, the action of galanin on the GH axis may be mediated through alpha-adrenergic pathways.
Positive_regulation (increased) of somatostatin associated with somatostatin and clonidine
19) Confidence 0.49 Published 1994 Journal Endocr. Res. Section Abstract Doc Link 7519979 Disease Relevance 0.06 Pain Relevance 0.55
The human 7-transmembrane receptor GPR7 has sequence similarity to opioid and somatostatin receptors, and can be activated by the recently discovered neuropeptides NPB and NPW.
Positive_regulation (activated) of somatostatin associated with neuropeptide, somatostatin and opioid
20) Confidence 0.49 Published 2005 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15607941 Disease Relevance 0.22 Pain Relevance 0.47

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