INT74122

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Emg1)
Emg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 5 100.00 Very High Very High Very High
depression 5 100.00 Very High Very High Very High
adenocard 6 99.50 Very High Very High Very High
narcan 2 96.90 Very High Very High Very High
Morphine 5 94.96 High High
antinociception 6 91.56 High High
withdrawal 4 88.36 High High
Endogenous opioid 1 76.08 Quite High
intrathecal 1 75.00 Quite High
agonist 1 66.64 Quite High
Disease Link Frequency Relevance Heat
Depression 7 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-frequency (1 ms pulses at 100 Hz for 2 s repeated three times at 10 s intervals) tetanic cES produced a significant long-term depression (LTD) (at least 3 h), but not LTP, of the electrically evoked SMU EMG activity as well as the wind-up phenomenon (temporal summation).
Neg (not) Gene_expression (produced) of SMU EMG associated with depression and long-term potentiation
1) Confidence 0.47 Published 2006 Journal Brain Res. Section Abstract Doc Link 16638604 Disease Relevance 0.51 Pain Relevance 0.57
The results showed that: 1) NE (3, 6, or 12 nmol) or 5-HT (60, 120, or 240 nmol) each produced a dose-dependent suppression of FR EMG, respectively; 2) pretreatment with Gli (5, 10, or 20 nmol) antagonized the NE (6 nmol)-induced antinociception in a dose-dependent manner and failed to modulate the 5-HT (120 nmol)-induced suppression of FR EMG; 3) pretreatment with Gli (5, 10, or 20 nmol) also antagonize the Mor (2 nmol)-induced suppression of FR EMG in a dose-dependent manner; 4) pretreatment with naloxone (Nal, 60, 120, or 240 nmol) also antagonize the NE (6 nmol)-induced suppression of FR EMG in a dose-dependent manner; and 5) NECA (0.5, 1.0, or 2.0 nmol) produced a dose-dependent suppression of FR EMG, while pretreatment with Gli (5, 10, or 20 nmol) failed to modulate the NECA (1.0 nmol)-induced suppression of FR EMG.
Gene_expression (produced) of FR EMG associated with antinociception, adenocard, narcan and morphine
2) Confidence 0.43 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9510418 Disease Relevance 0 Pain Relevance 1.31

General Comments

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