INT7413

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Context Info
Confidence 0.69
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 5.64
Pain Relevance 13.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
pituitary 10
somatotrope 4
plasma 2
adrenal cortex 2
thyroid 2
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 140 100.00 Very High Very High Very High
Clonidine 17 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
dexamethasone 4 100.00 Very High Very High Very High
neurotrophin 3 16 99.98 Very High Very High Very High
Neurotransmitter 18 99.80 Very High Very High Very High
Dopamine 2 99.72 Very High Very High Very High
Nerve growth factor 6 99.68 Very High Very High Very High
narcan 8 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 98.44 Very High Very High Very High
Diabetes Mellitus 5 98.30 Very High Very High Very High
Disease 48 96.64 Very High Very High Very High
Neurogenic Inflammation 8 96.56 Very High Very High Very High
Stress 91 95.52 Very High Very High Very High
Cancer 10 93.00 High High
Cushing's Syndrome /

Hypercortisolism

6 92.84 High High
Malignant Neoplastic Disease 5 91.76 High High
Adrenal Cancer 91 91.60 High High
Fibromyalgia 20 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phenytoin, another anticonvulsant with many similar properties, also blocked picrotoxin-induced somatostatin release at a concentration of 10(-4) M, and its effects were also reversed by veratridine at a concentration of 10(-5) M.
Positive_regulation (induced) of Localization (release) of somatostatin associated with somatostatin and anticonvulsant
1) Confidence 0.69 Published 1991 Journal Ann. Neurol. Section Abstract Doc Link 1681780 Disease Relevance 0 Pain Relevance 0.86
These data suggest that the inhibitory effect of glucocorticoid excess on GH release is due to increased hypothalamic somatostatin secretion which appears to be dependent on DEX-induced enhanced beta-adrenergic responsiveness.
Positive_regulation (dependent) of Localization (secretion) of somatostatin associated with somatostatin
2) Confidence 0.67 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8094392 Disease Relevance 0 Pain Relevance 0.12
These data suggest that the inhibitory effect of glucocorticoid excess on GH release is due to increased hypothalamic somatostatin secretion which appears to be dependent on DEX-induced enhanced beta-adrenergic responsiveness.
Positive_regulation (increased) of Localization (secretion) of somatostatin associated with somatostatin
3) Confidence 0.67 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8094392 Disease Relevance 0 Pain Relevance 0.12
CRH, on the one hand, activates the pituitary-adrenal axis, but also stimulates at the hypothalamic level somatostatin secretion which, in turn, causes inhibition of GH and TSH at the pituitary level.
Positive_regulation (stimulates) of Localization (secretion) of somatostatin in pituitary associated with somatostatin
4) Confidence 0.67 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 10025090 Disease Relevance 0.63 Pain Relevance 0.29
At this time, veratridine acted as a secretagogue, stimulating somatostatin secretion, but was also effective in stimulating somatostatin mRNA levels.
Positive_regulation (stimulating) of Localization (secretion) of somatostatin associated with somatostatin
5) Confidence 0.67 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717345 Disease Relevance 0 Pain Relevance 0.36
Acidification of a meal stimulates somatostatin release in dogs.
Positive_regulation (stimulates) of Localization (release) of somatostatin associated with somatostatin
6) Confidence 0.65 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2876504 Disease Relevance 0 Pain Relevance 0.49
Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively.
Positive_regulation (increased) of Localization (release) of somatostatin associated with somatostatin and substance p
7) Confidence 0.59 Published 1985 Journal Brain Res. Section Abstract Doc Link 2579706 Disease Relevance 0.07 Pain Relevance 0.52
The role of somatostatin in pathophysiological states such as peptic ulceration and diabetes mellitus is not entirely clear but the present evidence indicates that alterations of tissue somatostatin content or plasma somatostatin levels are secondary to changes of other factors (increased gastric acid secretion, insulin deficiency) rather than representing the primary cause for the underlying disease.
Positive_regulation (increased) of Localization (secretion) of somatostatin in plasma associated with diabetes mellitus, somatostatin and disease
8) Confidence 0.49 Published 1983 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6138852 Disease Relevance 0.19 Pain Relevance 0.67
CRH, on the one hand, activates the pituitary-adrenal axis, but also stimulates at the hypothalamic level somatostatin secretion which, in turn, causes inhibition of GH and TSH at the pituitary level.
Positive_regulation (stimulates) of Localization (secretion) of somatostatin in pituitary associated with somatostatin
9) Confidence 0.49 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 10025090 Disease Relevance 0.63 Pain Relevance 0.29
Agents widely used in clinical practice include: (a) uptake and storage of radiolabelled cholesterol analogues via the low density lipoprotein (LDL) receptor and cholesterol ester storage pool in the adrenal cortex ((131)I-6-beta-iodomethyl-norcholesterol, (75)Se-selenomethyl-norcholesterol); (b) catecholamine type I, presynaptic, uptake mechanism and intracellular granule uptake and storage mechanism in the adrenal medulla and extra-adrenal paraganglia ((131)I-, (123)I- and (124)I-meta-iodo-benzyl-guanidine (MIBG), (18)F-metafluoro-benzyl-guanidine); (c) cell surface receptor binding of peptides/neurotransmitters/modulators such as for the family of five subtypes of somatostatin receptors ((123)I-tyr-octreotide, (111)In-DTPA-octreotide, (111)In-DOTA-octreotide and many others); (d) although not specific for the adrenal gland, increased glycolysis by tumours, particularly the most malignant varieties, (18)F-2-fluoro-d-deoxyglucose can thus be expected to depict certain malignant lesions such as malignant pheochromocytomas (particularly the minority which are not detected by MIBG) and adrenal incidentalomas (particularly when they occur in patients with known extra-adrenal malignancies).
Positive_regulation (subtypes) of Localization (subtypes) of somatostatin in adrenal cortex associated with medulla, malignant neoplastic disease, neurotransmitter, cancer, catecholamine, somatostatin and pheochromocytoma
10) Confidence 0.49 Published 2002 Journal Eur. J. Endocrinol. Section Abstract Doc Link 12088915 Disease Relevance 0.51 Pain Relevance 0.26
A bilateral interaction has been demonstrated for neurogenic inflammation, which is accompanied by a segmentally organised short-lived suppression of this inflammatory response in the innervation territory of the respective contralateral nerve, mediated by somatostatin release [40].
Positive_regulation (mediated) of Localization (release) of somatostatin in nerve associated with inflammatory response, inflammation, somatostatin and neurogenic inflammation
11) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2453233 Disease Relevance 1.48 Pain Relevance 0.71
Furthermore, inhibition of pituitary GH secretion during puberty may occur due to increased hypothalamic somatostatin release as a result of glucocorticoid excess [49, 50].
Positive_regulation (increased) of Localization (release) of somatostatin in pituitary associated with somatostatin
12) Confidence 0.49 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2817857 Disease Relevance 0.31 Pain Relevance 0.13
They further suggest a defect in the release of pituitary GH secondary to an abnormality in alternative neurotransmitter pathways resulting in decreased GHRH and/or increased somatostatin secretion.
Positive_regulation (increased) of Localization (secretion) of somatostatin in pituitary associated with neurotransmitter and somatostatin
13) Confidence 0.49 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3018032 Disease Relevance 0 Pain Relevance 0.28
They further suggest a defect in the release of pituitary GH secondary to an abnormality in alternative neurotransmitter pathways resulting in decreased GHRH and/or increased somatostatin secretion.
Positive_regulation (resulting) of Localization (secretion) of somatostatin in pituitary associated with neurotransmitter and somatostatin
14) Confidence 0.49 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3018032 Disease Relevance 0 Pain Relevance 0.29
It can be hypothesized that clonidine does not elicit GH secretion decreasing hypothalamic somatostatin tone.
Neg (not) Positive_regulation (elicit) of Localization (secretion) of somatostatin associated with somatostatin and clonidine
15) Confidence 0.45 Published 1992 Journal Horm. Metab. Res. Section Abstract Doc Link 1398465 Disease Relevance 0.07 Pain Relevance 0.61
Stimulation of postprandial somatostatin release by H2-receptor agonists and prostaglandins has been reported.
Positive_regulation (Stimulation) of Localization (release) of somatostatin associated with agonist and somatostatin
16) Confidence 0.43 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2876504 Disease Relevance 0 Pain Relevance 0.57
It is assumed that the released SST is derived from the activated sensory nerves.
Positive_regulation (derived) of Localization (released) of SST in sensory nerves
17) Confidence 0.41 Published 2008 Journal Neuroimmunomodulation Section Body Doc Link 18716415 Disease Relevance 0 Pain Relevance 0
Similarly, exposure of the sst(2A)-MOR1 heterodimer to the mu-selective ligand [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin induced phosphorylation and desensitization of both MOR1 and sst(2A) but not internalization of sst(2A).
Positive_regulation (induced) of Localization (internalization) of sst associated with enkephalin
18) Confidence 0.40 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.30
Similarly, exposure of the sst(2A)-MOR1 heterodimer to the mu-selective ligand [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin induced phosphorylation and desensitization of both MOR1 and sst(2A) but not internalization of sst(2A).
Positive_regulation (induced) of Localization (internalization) of sst associated with enkephalin
19) Confidence 0.40 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.30
Similarly, exposure of the sst(2A)-MOR1 heterodimer to the mu-selective ligand [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin induced phosphorylation and desensitization of both MOR1 and sst(2A) but not internalization of sst(2A).
Positive_regulation (induced) of Localization (internalization) of sst associated with enkephalin
20) Confidence 0.40 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.31

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