INT74131

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Context Info
Confidence 0.50
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.92
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo) aging (Tspo) response to stress (Tspo)
Anatomy Link Frequency
spinal 1
Tspo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 100.00 Very High Very High Very High
gABA 3 100.00 Very High Very High Very High
IPN 2 96.76 Very High Very High Very High
5HT 2 96.24 Very High Very High Very High
fluoxetine 4 95.16 Very High Very High Very High
long-term potentiation 12 95.12 Very High Very High Very High
Potency 1 89.36 High High
Spinal cord 2 88.08 High High
antagonist 3 86.40 High High
spinal dorsal horn 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Panic Disorder 1 97.22 Very High Very High Very High
Inflammatory Pain 2 96.76 Very High Very High Very High
Anxiety Disorder 8 96.56 Very High Very High Very High
Low Back Pain 1 75.00 Quite High
Urological Neuroanatomy 1 72.96 Quite High
Stress 4 71.08 Quite High
Pain 1 55.00 Quite High
Neuritis 1 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a recent study it has been shown that benzodiazepine receptor agonists attenuate novelty-induced suppression of feeding and increase the percentage of animals feeding in the open field.
Positive_regulation (increase) of benzodiazepine receptor associated with agonist
1) Confidence 0.50 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9512071 Disease Relevance 0.15 Pain Relevance 0.05
CONCLUSIONS: Surgical stress increases benzodiazepine receptor density but does not alter affinity.
Positive_regulation (increases) of benzodiazepine receptor
2) Confidence 0.49 Published 2006 Journal Rev Esp Anestesiol Reanim Section Body Doc Link 17125013 Disease Relevance 0.06 Pain Relevance 0
RESULTS: The surgically manipulated groups, whether treated with morphine or not, displayed increased benzodiazepine receptor density in comparison with naive animals for all receptor subtypes.
Positive_regulation (increased) of benzodiazepine receptor
3) Confidence 0.49 Published 2006 Journal Rev Esp Anestesiol Reanim Section Body Doc Link 17125013 Disease Relevance 0.07 Pain Relevance 0
These results suggest that diazepam might prevent and depress spinal plastic change produced by noxious stimulation via activation of the GABA(A) -benzodiazepine receptor complex.
Positive_regulation (activation) of benzodiazepine receptor in spinal associated with gaba
4) Confidence 0.19 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16324725 Disease Relevance 0.06 Pain Relevance 1.02
In this paradigm which has been validated as a simulation of acute anxiety with relevance to panic disorder, the selective activation of 5HT2C receptors by Ro 60-0175, Org 12962 or Ro 60-0332 induces effects analogous to those observed following benzodiazepine receptor activation by antipanic agents such as clonazepam or alprazolam or following non-selective and indirect 5HT receptor activation by fluoxetine.
Positive_regulation (activation) of benzodiazepine receptor associated with panic disorder, anxiety disorder, 5ht and fluoxetine
5) Confidence 0.16 Published 1998 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 9716307 Disease Relevance 0.41 Pain Relevance 0.68
As shown by these plots, by increasing the electrode density a stable MFR and MBR is reached especially for experiments 2, 3 and 7.
Positive_regulation (increasing) of MBR
6) Confidence 0.16 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2871691 Disease Relevance 0 Pain Relevance 0
The production of 5alpha-reduced neurosteroids is controlled by the endogenous activation of the peripheral benzodiazepine receptor (PBR), which initiates the first step of neurosteroidogenesis by stimulating the translocation of cholesterol across the inner mitochondrial membrane.
Positive_regulation (activation) of peripheral benzodiazepine receptor
7) Confidence 0.08 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632874 Disease Relevance 0.17 Pain Relevance 0.37

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