INT7414

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 31
Total Number 35
Disease Relevance 4.85
Pain Relevance 17.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
neural 4
pancreas 4
plasma 2
gastroepiploic vein 2
cerebrospinal fluid 2
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 277 100.00 Very High Very High Very High
Serotonin 35 100.00 Very High Very High Very High
substance P 32 100.00 Very High Very High Very High
Clonidine 29 100.00 Very High Very High Very High
Enkephalin 25 100.00 Very High Very High Very High
narcan 25 100.00 Very High Very High Very High
qutenza 12 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 107 100.00 Very High Very High Very High
Duodenal Ulcer 18 100.00 Very High Very High Very High
Disease 37 99.00 Very High Very High Very High
Hypoglycemia 6 98.88 Very High Very High Very High
Natriuresis 1 98.20 Very High Very High Very High
Pituitary Cancer 12 97.80 Very High Very High Very High
Stress 4 94.16 High High
Obesity 4 94.04 High High
Acromegaly 10 93.48 High High
Adenocarcinoma 3 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of gastric and pancreatic somatostatin is regulated by ingested and circulating nutrients and is modulated by neural mechanisms (cholinergic, adrenergic, dopaminergic) histamine, prostaglandins, opiates and gastrointestinal hormones.
Regulation (regulated) of Localization (release) of somatostatin in neural associated with somatostatin and opiate
1) Confidence 0.60 Published 1983 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6138852 Disease Relevance 0.06 Pain Relevance 0.70
The release of gastric and pancreatic somatostatin is regulated by ingested and circulating nutrients and is modulated by neural mechanisms (cholinergic, adrenergic, dopaminergic) histamine, prostaglandins, opiates and gastrointestinal hormones.
Regulation (modulated) of Localization (release) of somatostatin in neural associated with somatostatin and opiate
2) Confidence 0.60 Published 1983 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6138852 Disease Relevance 0.07 Pain Relevance 0.72
Other stimuli like hypoglycaemia, arginine and propranolol augment GH release in man by modulating hypothalamic somatostatin secretion.
Regulation (modulating) of Localization (secretion) of somatostatin associated with hypoglycemia and somatostatin
3) Confidence 0.60 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1901390 Disease Relevance 0.19 Pain Relevance 0.14
Effects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined.
Spec (examined) Regulation (Effects) of Localization (release) of somatostatin in dorsal horn associated with dorsal horn, somatostatin and substance p
4) Confidence 0.44 Published 1985 Journal Brain Res. Section Abstract Doc Link 2579706 Disease Relevance 0.07 Pain Relevance 0.50
The present study was performed to evaluate the effects of a slow release formulation of the somatostatin analog lanreotide (SR-L) on both hormone secretion and tumor size and to assess the tolerance in a series of thyrotropinomas treated for 6 months.
Regulation (effects) of Localization (release) of somatostatin associated with cancer, tolerance and somatostatin
5) Confidence 0.44 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10770186 Disease Relevance 0.44 Pain Relevance 0.22
No such expression was seen on glucagon secreting A cells or somatostatin secreting D cells.
Regulation (seen) of Localization (secreting) of somatostatin in D cells associated with somatostatin
6) Confidence 0.44 Published 1987 Journal Diabetologia Section Abstract Doc Link 3301484 Disease Relevance 0.56 Pain Relevance 0.05
Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons.
Spec (may) Regulation (involve) of Localization (release) of SST in neurons associated with somatostatin
7) Confidence 0.27 Published 2010 Journal Gastroenterology Section Abstract Doc Link 19786030 Disease Relevance 0.09 Pain Relevance 0.27
Studies in animals and humans demonstrate an anatomic, physiological and pharmacological evidence for neurosecretory control over GH secretion including neurohormones (GRH, somatostatin), neurotransmitters (dopaminergic, adrenergic, cholinergic, serotonergic, histaminergic, GABAergic), and neuropeptides (gut hormones, opioids, CRH, TRH, etc).
Regulation (control) of Localization (secretion) of somatostatin in gut associated with neurotransmitter, gabaergic, neuropeptide, somatostatin and opioid
8) Confidence 0.26 Published 1986 Journal Clin Endocrinol Metab Section Abstract Doc Link 2429794 Disease Relevance 0.07 Pain Relevance 0.32
The absence of any either synergistic or at least additive effect on GH secretion of galanin and clonidine in conditions of both normal and increased somatostatin tone suggests that also in man, as well as in the rat, the action of galanin on the GH axis may be mediated through alpha-adrenergic pathways.
Regulation (effect) of Localization (secretion) of somatostatin associated with somatostatin and clonidine
9) Confidence 0.26 Published 1994 Journal Endocr. Res. Section Abstract Doc Link 7519979 Disease Relevance 0.06 Pain Relevance 0.59
The absence of any either synergistic or at least additive effect on GH secretion of galanin and clonidine in conditions of both normal and increased somatostatin tone suggests that also in man, as well as in the rat, the action of galanin on the GH axis may be mediated through alpha-adrenergic pathways.
Regulation (absence) of Localization (secretion) of somatostatin associated with somatostatin and clonidine
10) Confidence 0.26 Published 1994 Journal Endocr. Res. Section Abstract Doc Link 7519979 Disease Relevance 0.06 Pain Relevance 0.60
We suggest that the specific activation of delta-opioid receptors in man may exert an inhibitory influence on GH secretion principally by modulating endogenous hypothalamic somatostatin (SRIH) release.
Regulation (modulating) of Localization (release) of somatostatin associated with somatostatin and delta opioid receptors
11) Confidence 0.26 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8570858 Disease Relevance 0 Pain Relevance 0.21
Vagal, cholinergic, and adrenergic mechanisms exert a species-dependent effect on somatostatin release.
Regulation (effect) of Localization (release) of somatostatin associated with somatostatin
12) Confidence 0.25 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2876504 Disease Relevance 0 Pain Relevance 0.54
Somatostatin secretion is a direct effect of acid on the somatostatin cell, since it is unaffected by the axonal blocker tetrodotoxin.
Regulation (effect) of Localization (secretion) of Somatostatin associated with tetrodotoxin and somatostatin
13) Confidence 0.24 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2876506 Disease Relevance 0.13 Pain Relevance 0.71
The aim of this study was to investigate the interrelationships between alpha 2-adrenergic and cholinergic pathways in the control of hypothalamic somatostatin (SRIF) secretion in humans.
Regulation (control) of Localization (secretion) of somatostatin associated with somatostatin
14) Confidence 0.23 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1677361 Disease Relevance 0 Pain Relevance 0.23
The synthesis and secretion of the natural ligand somatostatin-14 by sst2-transfected cells was responsible for an autocrine/paracrine inhibitory loop [57].
Regulation (responsible) of Localization (secretion) of somatostatin associated with somatostatin
15) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.93 Pain Relevance 0.15
There were no significant changes compared to baseline in the cerebrospinal fluid concentrations of enkephalins, dynorphin A, the norepinephrine metabolite 3-methoxy-4-hydroxyphenyl-ethyleneglycol, the serotonin metabolite 5-hydroxyindoleacetic acid, gamma-aminobutyric acid, somatostatin or corticotropin-releasing factor.
Regulation (concentrations) of Localization (releasing) of somatostatin in cerebrospinal fluid associated with dynorphin, somatostatin, enkephalin and serotonin
16) Confidence 0.22 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7537355 Disease Relevance 0.06 Pain Relevance 0.44
Somatostatin release in dogs is modulated by exogenous and endogenous opioids.
Regulation (modulated) of Localization (release) of Somatostatin associated with endogenous opioid and somatostatin
17) Confidence 0.20 Published 1985 Journal Peptides Section Abstract Doc Link 2867525 Disease Relevance 0 Pain Relevance 0.50
We have examined the effects of several neuropeptides on the release of immunoreactive somatostatin from cerebral cortical cells in vitro.
Spec (examined) Regulation (effects) of Localization (release) of somatostatin associated with somatostatin and neuropeptide
18) Confidence 0.18 Published 1985 Journal Brain Res. Section Abstract Doc Link 2859907 Disease Relevance 0 Pain Relevance 0.42
These data indicate that clonidine was able to disrupt the intrinsic hypothalamic-somatotroph rhythm, suggesting that alpha 2-adrenergic pathways have a major inhibitory effect on somatostatin release.
Regulation (effect) of Localization (release) of somatostatin in somatotroph associated with somatostatin and clonidine
19) Confidence 0.15 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1977761 Disease Relevance 0 Pain Relevance 0.71
A number of other neurotrasmitters and neuropeptides can also modulate prolactin secretion, among which galanin, endothelin, TGFbeta1, angiotensin, somatostatin, substance P, neurotensin, calcitonin, EGF, natriuretic atrial peptide, bombesin, colecistokinine, acetylcholine, vasopressin (Figure 1).
Regulation (modulate) of Localization (secretion) of somatostatin associated with natriuresis, somatostatin, neuropeptide and substance p
20) Confidence 0.15 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.33 Pain Relevance 0.27

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