INT74155

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
sciatic nerves 1
TMJ 1
Il12b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
Inflammation 4 97.40 Very High Very High Very High
Neuritis 4 92.20 High High
Sciatic nerve 1 90.32 High High
Demyelination 1 75.00 Quite High
Peripheral nervous system 1 75.00 Quite High
spastic colon 1 68.08 Quite High
Osteoarthritis 2 50.00 Quite Low
Snapping jaw 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 97.40 Very High Very High Very High
Hypersensitivity 3 96.88 Very High Very High Very High
Experimental Autoimmune Neuritis 4 93.16 High High
Wallerian Degeneration 3 89.28 High High
Asthma 1 75.12 Quite High
Demyelinating Disease 1 75.00 Quite High
Conjunctivitis 1 73.92 Quite High
Rhinitis 1 72.64 Quite High
Urticaria 1 71.84 Quite High
Eczema 1 70.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the time course of mRNA levels of the proinflammatory cytokines interferon-gamma (IFNgamma), interleukin-1beta (IL1beta), interleukin-12 (IL12; p40 subunit), and the immunosuppressant interleukin-10 (IL10) by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) in rats with actively induced experimental autoimmune neuritis (EAN) and in distal stumps of crushed sciatic nerves undergoing Wallerian degeneration.
Transcription (levels) of IL12 in sciatic nerves associated with experimental autoimmune neuritis, wallerian degeneration, sciatic nerve, neuritis and cytokine
1) Confidence 0.60 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.57 Pain Relevance 0.50
Bacteria and bacterial products are capable of stimulating the transcription of the maturational cytokines IL12 and IFNs through the activation of Toll-Like-Receptor and the subsequent nuclear translocation of the NF-kappaB factor.
Transcription (transcription) of IL12 associated with cytokine
2) Confidence 0.13 Published 2004 Journal Eur Ann Allergy Clin Immunol Section Abstract Doc Link 15180351 Disease Relevance 0.77 Pain Relevance 0.17
Furthermore, an inflammatory response characterised by the predominant expression of IL12 mRNA and down-regulated expression of IL10 mRNA is associated with the degenerative changes observed in OA-TMJ.


Transcription (expression) of IL12 in TMJ
3) Confidence 0.13 Published 2008 Journal Arch. Oral Biol. Section Body Doc Link 18508030 Disease Relevance 0.11 Pain Relevance 0

General Comments

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