INT74157

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.83
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
nerve 2
lung 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 43 100.00 Very High Very High Very High
cytokine 14 100.00 Very High Very High Very High
antagonist 1 99.24 Very High Very High Very High
rheumatoid arthritis 4 98.32 Very High Very High Very High
Pain 3 97.60 Very High Very High Very High
Arthritis 5 91.12 High High
Inflammatory mediators 2 86.80 High High
Neuritis 4 85.56 High High
Migraine 11 85.36 High High
Sciatic nerve 1 83.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 36 100.00 Very High Very High Very High
Lung Injury 58 99.46 Very High Very High Very High
Rheumatoid Arthritis 4 98.32 Very High Very High Very High
Pain 1 97.60 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

1 95.20 Very High Very High Very High
Insulin Resistance 1 94.60 High High
Obesity 2 91.88 High High
Experimental Arthritis 3 91.12 High High
Adult Respiratory Distress Syndrome 7 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After nerve crush both IL1beta- and IL10-mRNA were rapidly upregulated in the distal stump at day 1 and slowly declined over the next 2 weeks.
Negative_regulation (declined) of Positive_regulation (upregulated) of IL10-mRNA in nerve
1) Confidence 0.43 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9514202 Disease Relevance 0.57 Pain Relevance 0.69
Moreover, the immunomodulatory properties of BLF, such as down-regulation of TNF-alpha and up-regulation of IL-10, could be beneficial in the treatment of RA.
Negative_regulation (down-regulation) of Positive_regulation (up-regulation) of IL-10 associated with rheumatoid arthritis
2) Confidence 0.39 Published 2004 Journal J. Vet. Med. Sci. Section Abstract Doc Link 15031542 Disease Relevance 1.18 Pain Relevance 0.96
APAP also attenuated LPS-induced increases in IL-10 and MCP-1.
Negative_regulation (attenuated) of Positive_regulation (increases) of IL-10
3) Confidence 0.24 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.37 Pain Relevance 0.25
Comparably, in models of lung injury, bolus treatment with H2S reduced levels of IL-1 and IL-8 and increased levels of IL-10 [14].
Negative_regulation (reduced) of Positive_regulation (increased) of IL-10 in lung associated with lung injury
4) Confidence 0.07 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2952106 Disease Relevance 1.62 Pain Relevance 0.41
The anti-inflammatory activities of adiponectin include inhibition of IL-6 and TNF-induced IL-8 formation, as well as induction of the anti-inflammatory cytokines IL-10 and IL-1 receptor antagonist.
Negative_regulation (inhibition) of Positive_regulation (induction) of cytokines IL-10 associated with inflammation, antagonist and cytokine
5) Confidence 0.00 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17448181 Disease Relevance 1.99 Pain Relevance 1.25

General Comments

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