INT74166

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.83
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular region (C2)
Anatomy Link Frequency
articulation 1
neck 1
dens 1
central nervous system 1
C2 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 30 99.98 Very High Very High Very High
qutenza 15 99.16 Very High Very High Very High
Glutamate 14 98.56 Very High Very High Very High
transcutaneous nerve stimulation 6 96.56 Very High Very High Very High
Facet joint 10 96.48 Very High Very High Very High
Central nervous system 1 95.28 Very High Very High Very High
Glutamate receptor 2 95.12 Very High Very High Very High
Inflammation 26 82.00 Quite High
anesthesia 1 63.40 Quite High
nMDA receptor antagonist 1 54.88 Quite High
Disease Link Frequency Relevance Heat
Tinnitus 9 99.36 Very High Very High Very High
Injury 121 96.44 Very High Very High Very High
Rupture 6 96.16 Very High Very High Very High
Dysphagia 7 90.64 High High
Syndrome 4 90.24 High High
Mycobacterial Infection 4 82.64 Quite High
INFLAMMATION 28 82.00 Quite High
Toxicity 1 81.40 Quite High
Graft Vs Host Disease 4 80.76 Quite High
Nociception 11 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As electrical stimulation of C2 increases activation of the DCN through the somatosensory pathway and enlarges the inhibitory role of the DCN on the central nervous system, C2 TENS can be considered for tinnitus modulation.
Positive_regulation (stimulation) of C2 in central nervous system associated with tinnitus, transcutaneous nerve stimulation and central nervous system
1) Confidence 0.55 Published 2010 Journal Exp Brain Res Section Abstract Doc Link 20505927 Disease Relevance 0.65 Pain Relevance 0.45
Carnahan et al have also reported similar findings in a well-designed study from Tennessee, USA.[5] We also observed that C2 levels remained unchanged after conversion to Imusporin.
Neg (unchanged) Positive_regulation (unchanged) of C2
2) Confidence 0.46 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721520 Disease Relevance 0.24 Pain Relevance 0
Thus, these previous findings and the present results suggested that the antinociceptive action of compounds C1 and C2 in the acetic acid, capsaicin, and glutamate tests could be the result of both the inhibition of NOS and the blockade of glutamate receptors.
Positive_regulation (action) of C2 associated with glutamate, qutenza, glutamate receptor and antinociceptive
3) Confidence 0.43 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2817697 Disease Relevance 0.27 Pain Relevance 0.37
The ESPDR was significantly curvilinear and increased convexity after isoproterenol injection (C2, -444+/-281 to -1113+/-780 mmHg/mm2, P<0. 05; E0, 536+/-175 to 889+/-276 mmHg/mm, P<0.001), while the dimension axis intercept remained relatively constant (D0, 5.39+/-0. 46 to 5.37+/-0.52 mm).
Positive_regulation (increased) of C2
4) Confidence 0.31 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9515012 Disease Relevance 0 Pain Relevance 0.06
The Mannan-binding lectin complex is closely homologous to C1q and can activate C2 and C4[50].
Positive_regulation (activate) of C2
5) Confidence 0.16 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.05 Pain Relevance 0
C3b forms the central protein complex of the complement system either by binding to complement receptors or by complexing with C2aC4b to form C5 convertase, C2aC4bC3b.
Positive_regulation (form) of C5 convertase
6) Confidence 0.12 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.19 Pain Relevance 0
Propagation of complement activation by the C3 convertase results in the generation of a C5 convertase on cell surfaces.
Positive_regulation (generation) of C5 convertase
7) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.14 Pain Relevance 0.04
This patient presented late with persistent nonunion of the dens fracture for which an instrumented C0-C2 fusion was performed.
Positive_regulation (instrumented) of C2 in dens
8) Confidence 0.03 Published 2007 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2989524 Disease Relevance 0.85 Pain Relevance 0.04
The biomechanics of surgical stabilization of the C1-C2 articulation can be divided into three different types.
Positive_regulation (stabilization) of C2 in articulation
9) Confidence 0.03 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2995783 Disease Relevance 0 Pain Relevance 0.04
Though it is technically difficult to reach C2 with a short neck and limited extension, it is possible with reasonable safety.
Positive_regulation (reach) of C2 in neck
10) Confidence 0.03 Published 2007 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2989524 Disease Relevance 0.44 Pain Relevance 0
Three-point fixation consists of the combination of the two previous principles, thus stabilizing the C1-C2 motion segment both laterally and posteriorly.
Positive_regulation (stabilizing) of C2
11) Confidence 0.03 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2995783 Disease Relevance 0 Pain Relevance 0.05

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