INT74177

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.77
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HMBS) small molecule metabolic process (HMBS) nucleus (HMBS)
cytoplasm (HMBS)
Anatomy Link Frequency
heart 2
HMBS (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 1 95.64 Very High Very High Very High
abdominal pain 1 90.80 High High
agonist 20 82.64 Quite High
dexamethasone 1 76.64 Quite High
Inflammation 24 62.92 Quite High
palliative 1 51.36 Quite High
Kinase C 1 7.96 Low Low
cINOD 11 5.00 Very Low Very Low Very Low
COX-2 inhibitor 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dilated Cardiomyopathy 1 99.66 Very High Very High Very High
Congenital Anomalies 3 99.06 Very High Very High Very High
Coronary Heart Disease 5 97.28 Very High Very High Very High
Infection 1 97.04 Very High Very High Very High
Porphyria 13 96.36 Very High Very High Very High
Cancer 132 92.40 High High
Left Ventricular Hypertrophy 1 91.44 High High
Abdominal Pain 1 90.80 High High
Esophageal Cancer 14 88.40 High High
Heart Rate Under Development 5 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Vandesompele et al., 2002) At least three out of the following four housekeeping genes were used for each experiment: glyceraldehyde-3 phosphate dehydrogenase (GAPDH), hypoxanthine phosphoribosyltransferase 1 (HPRT1), human porphobilinogen deaminase (PBGD) and TATA box binding protein (TBP).
Positive_regulation (experiment) of Gene_expression (used) of PBGD
1) Confidence 0.49 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481577 Disease Relevance 0.29 Pain Relevance 0
(Vandesompele et al., 2002) At least three out of the following four housekeeping genes were used for each experiment: glyceraldehyde-3 phosphate dehydrogenase (GAPDH), hypoxanthine phosphoribosyltransferase 1 (HPRT1), human porphobilinogen deaminase (PBGD) and TATA box binding protein (TBP).
Positive_regulation (experiment) of Gene_expression (used) of porphobilinogen deaminase
2) Confidence 0.49 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1481577 Disease Relevance 0.29 Pain Relevance 0
These results show that non-viral gene delivery of plasmids encoding PBGD results in a high expression of functional PBGD shown by induced synthesis of PP in PBGD deficient cells after supplementation of ALA and PBG.
Positive_regulation (results) of Gene_expression (expression) of PBGD associated with porphyria
3) Confidence 0.40 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 12962144 Disease Relevance 0.40 Pain Relevance 0.05
to control the expression of components of the UPS, like ubiquitin ligases, or via
Positive_regulation (components) of Gene_expression (expression) of UPS
4) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.17 Pain Relevance 0.07
Biochemical abnormalities are thought to result from primary defects of porphobilinogen deaminase (PBGD; also called hydroxymethyl bilane synthase), the third enzyme of the heme synthesis pathway, and consecutive hepatic overexpression of the first enzyme of the pathway, 5-aminolevulinate synthase.
Positive_regulation (overexpression) of Gene_expression (overexpression) of porphobilinogen deaminase associated with congenital anomalies
5) Confidence 0.05 Published 1998 Journal Semin. Liver Dis. Section Abstract Doc Link 9516674 Disease Relevance 0.69 Pain Relevance 0.14
Furthermore, in dilated cardiomyopathy (DCM) patients, increased expression of regulatory proteins of the UPS was demonstrated by functional proteomics in heart tissue specimens.
Positive_regulation (increased) of Gene_expression (expression) of UPS in heart associated with dilated cardiomyopathy
6) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1475607 Disease Relevance 0.94 Pain Relevance 0.04

General Comments

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