INT74182

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2004
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.39
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
brains 2
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 29 100.00 Very High Very High Very High
narcan 9 100.00 Very High Very High Very High
Physical dependence 3 100.00 Very High Very High Very High
Morphine 2 99.96 Very High Very High Very High
Immobilon 12 99.68 Very High Very High Very High
opioid receptor 6 99.40 Very High Very High Very High
agonist 32 98.40 Very High Very High Very High
butorphanol 3 97.94 Very High Very High Very High
Delta opioid receptors 1 95.40 Very High Very High Very High
MU agonist 2 95.00 High High
Disease Link Frequency Relevance Heat
Drug Dependence 3 100.00 Very High Very High Very High
Disease 6 98.88 Very High Very High Very High
Opiate Addiction 4 89.80 High High
Attention Deficit Hyperactivity Disorder 1 72.68 Quite High
Bordatella Infection 4 69.08 Quite High
Dementia 2 65.68 Quite High
Cognitive Disorder 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results from structure-function studies suggested that the nature of the substituent at the 2-position of salvinorin A was critical for kappa-opioid receptor binding and activation.
Positive_regulation (critical) of kappa-opioid receptor Binding (binding) of associated with kappa opioid receptor
1) Confidence 0.49 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718611 Disease Relevance 0 Pain Relevance 0.73
Whereas a phenylethyl group is able to create affinity to the mu-receptor, small substituents such as a hydrogen or a methyl group are responsible for a high affinity to the kappa-receptor.
Positive_regulation (responsible) of kappa-receptor Binding (affinity) of
2) Confidence 0.48 Published 2000 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 10965597 Disease Relevance 0 Pain Relevance 0.08
In contrast, large increases of kappa-opioid receptor binding are found in the dorsal and ventral putamen as well as in the cerebellar cortex of Alzheimer's disease brains.
Positive_regulation (increases) of kappa-opioid receptor Binding (binding) of in brains associated with kappa opioid receptor and disease
3) Confidence 0.41 Published 2001 Journal Brain Res. Section Abstract Doc Link 11223000 Disease Relevance 0.55 Pain Relevance 0.66
In addition, internalization of the kappa receptor is not required for activation of MAP kinase.
Neg (not) Positive_regulation (required) of kappa receptor Binding (internalization) of
4) Confidence 0.25 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10207034 Disease Relevance 0.05 Pain Relevance 0.21
U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism.
Positive_regulation (U50,488H-induced) of kappa opioid receptor Binding (internalization) of associated with narcan and kappa opioid receptor
5) Confidence 0.22 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10207034 Disease Relevance 0 Pain Relevance 0.50
In addition, etorphine, which did not promote human kappa receptor internalization, was able to fully activate MAP kinase.
Neg (not) Positive_regulation (promote) of kappa receptor Neg (not) Binding (internalization) of associated with immobilon
6) Confidence 0.22 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10207034 Disease Relevance 0.07 Pain Relevance 0.34
Kappa receptor internalization is not <span style="background-color:<span style="background-color:#FFFF00">#B0E0E6">requi</span>red</span> for mitogen-activated protein kinase activation.
Positive_regulation (required) of kappa opioid receptor Binding (internalization) of
7) Confidence 0.22 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10207034 Disease Relevance 0.05 Pain Relevance 0.47
Butorphanol (Stadol), which exhibits a markedly different profile of opioid receptor activity than does morphine, produces its physical dependence primarily through actions at the kappa-opioid receptor.
Positive_regulation (produces) of kappa-opioid receptor Binding (actions) of associated with physical dependence, kappa opioid receptor, butorphanol, opioid receptor and morphine
8) Confidence 0.21 Published 1998 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 9517399 Disease Relevance 0.67 Pain Relevance 2.26

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