INT74203

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.33
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Gtpbp4) nucleolus (Gtpbp4) nucleus (Gtpbp4)
GTPase activity (Gtpbp4) ribosome biogenesis (Gtpbp4) cytoplasm (Gtpbp4)
Anatomy Link Frequency
hippocampus 3
spinal 2
neurons 2
cerebellum 1
Gtpbp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 15 99.98 Very High Very High Very High
Neuropeptide 5 99.94 Very High Very High Very High
Thermal hyperalgesia 2 99.82 Very High Very High Very High
Hippocampus 4 99.68 Very High Very High Very High
withdrawal 10 99.48 Very High Very High Very High
substance P 10 99.22 Very High Very High Very High
Analgesic 2 98.98 Very High Very High Very High
intrathecal 4 98.76 Very High Very High Very High
agonist 5 98.24 Very High Very High Very High
narcan 3 95.00 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 99.82 Very High Very High Very High
Nociception 1 94.48 High High
Catatonia 1 45.36 Quite Low
Pain 1 25.00 Low Low
Injury 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also found that the C3 phenolic group is favourable for G-protein activation.
Positive_regulation (favourable) of Positive_regulation (activation) of G-protein
1) Confidence 0.50 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12020678 Disease Relevance 0 Pain Relevance 0.43
Morphine-induced maximal stimulation of G-protein in morphine withdrawal group (83.60%) was significantly higher compared to placebo control group (66.81%).
Positive_regulation (induced) of Positive_regulation (stimulation) of G-protein associated with withdrawal and morphine
2) Confidence 0.17 Published 2006 Journal Peptides Section Abstract Doc Link 16293342 Disease Relevance 0 Pain Relevance 1.81
When loaded with GTP-gamma-S, a non-hydrolysable analogue of GTP, vagal neurons generated a persistent inward current in the absence of agonist and the oxytocin effect was suppressed, suggesting that the peptide-evoked current was mediated by G-protein activation.
Positive_regulation (mediated) of Positive_regulation (activation) of G-protein in neurons associated with agonist
3) Confidence 0.09 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9517466 Disease Relevance 0 Pain Relevance 0.39
Lack of effects by sigma ligands on neuropeptide Y-induced G-protein activation in rat hippocampus and cerebellum.
Positive_regulation (induced) of Positive_regulation (activation) of G-protein in hippocampus associated with analgesic, neuropeptide and hippocampus
4) Confidence 0.09 Published 2001 Journal Brain Res. Section Title Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.35
Our previous study has shown that spinal (intrathecal, IT) application of SP produces thermal hyperalgesia that is mediated by activation of the G-protein coupled NK1 receptor.
Positive_regulation (mediated) of Positive_regulation (activation) of G-protein in spinal associated with thermal hyperalgesia, substance p and intrathecal
5) Confidence 0.07 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986346 Disease Relevance 0.33 Pain Relevance 0.80
Lack of effects by sigma ligands on neuropeptide Y-induced G-protein activation in rat hippocampus and cerebellum.
Positive_regulation (induced) of in cerebellum Positive_regulation (activation) of G-protein in hippocampus associated with analgesic, neuropeptide and hippocampus
6) Confidence 0.03 Published 2001 Journal Brain Res. Section Title Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.35

General Comments

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