INT74217

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Context Info
Confidence 0.18
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1, Icam1) extracellular space (Icam1) cell adhesion (Icam1)
signal transducer activity (Oprl1)
Anatomy Link Frequency
joints 2
Oprl1 (Rattus norvegicus)
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 2 50.00 Quite Low
MU agonist 2 50.00 Quite Low
Arthritis 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 54.44 Quite High
Arthritis 2 51.28 Quite High
Adhesions 2 50.00 Quite Low
Experimental Arthritis 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears that the kappa-opioid PD117302, but not the NSAID naproxen, inhibits the upregulation of ICAM-1 in arthritic joints, suggesting these agents act via different mechanisms.
kappa-opioid PD117302 Negative_regulation (inhibits) of Positive_regulation (upregulation) of ICAM-1 in joints
1) Confidence 0.18 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0.11 Pain Relevance 0

General Comments

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