INT74237

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.92
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (Ppt1) extracellular space (Ppt1) cofactor metabolic process (Ppt1)
extracellular region (Ppt1) Golgi apparatus (Ppt1) nucleus (Ppt1)
Anatomy Link Frequency
spine 1
arm 1
extracellular matrix 1
Ppt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain threshold 5 100.00 Very High Very High Very High
metalloproteinase 1 100.00 Very High Very High Very High
visual analogue scale 3 97.40 Very High Very High Very High
Pain 52 96.68 Very High Very High Very High
analgesia 1 91.24 High High
referred pain 4 83.08 Quite High
lumbar region 14 81.68 Quite High
Deep tissue 3 75.00 Quite High
hypoalgesia 1 75.00 Quite High
diffuse noxious inhibitory control 1 65.60 Quite High
Disease Link Frequency Relevance Heat
Pain 48 100.00 Very High Very High Very High
Metastasis 4 99.92 Very High Very High Very High
Glioblastoma 1 99.34 Very High Very High Very High
Myalgia 6 96.96 Very High Very High Very High
Stomach Cancer 5 91.44 High High
Cancer 149 87.12 High High
Referred Pain 4 83.08 Quite High
Hypoalagesia 1 75.00 Quite High
INFLAMMATION 47 65.52 Quite High
Bladder Cancer 1 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, Stat3 is part of the transcriptional network that mediates epithelial-to-mesenchymal (EMT) transformation in glioblastoma [80] and promotes metastasis by induction of the extracellular matrix-degrading metalloproteinases, including MMP-2 and MMP-9 [81].
Positive_regulation (induction) of incl in extracellular matrix associated with glioblastoma, metalloproteinase and metastasis
1) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.10 Pain Relevance 0.08
A significant (P<0.04) increase of the PPT (i.e., decreased sensibility) was found at the ankle and on the arm during muscle pain compared to the control condition.
Positive_regulation (increase) of PPT in arm associated with pain, pain threshold and myalgia
2) Confidence 0.40 Published 1998 Journal Brain Res. Section Abstract Doc Link 9518613 Disease Relevance 1.31 Pain Relevance 1.69
The assessments along the spine did not show distinct differences in sensitivity but showed a gradual increase in PPT in the caudal direction in line with a recent study by O'Neill et al. [39].
Positive_regulation (increase) of PPT in spine
3) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2964538 Disease Relevance 0.51 Pain Relevance 0.55

General Comments

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