INT74241

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 4.93
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (EDA) cell differentiation (EDA) signal transduction (EDA)
extracellular region (EDA) plasma membrane (EDA) cytoskeleton (EDA)
Anatomy Link Frequency
articular 4
macrophages 2
monocyte 2
EDA (Homo sapiens)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 99.80 Very High Very High Very High
Inflammation 139 99.72 Very High Very High Very High
tolerance 2 99.26 Very High Very High Very High
glial activation 2 94.56 High High
Neuritis 4 89.20 High High
Multiple sclerosis 11 88.44 High High
withdrawal 1 83.72 Quite High
cytokine 28 78.08 Quite High
Spinal cord 2 78.04 Quite High
Central nervous system 1 74.92 Quite High
Disease Link Frequency Relevance Heat
Arthritis 12 99.96 Very High Very High Very High
Hyperalgesia 5 99.80 Very High Very High Very High
Multiple Sclerosis 5 99.72 Very High Very High Very High
INFLAMMATION 141 98.00 Very High Very High Very High
Disease 72 94.76 High High
Sepsis 20 91.12 High High
Optic Neuritis 4 89.20 High High
Demyelinating Disease 13 88.44 High High
Experimental Autoimmune Encephalomyelitis 1 87.24 High High
Cancer 6 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intra-articular injection of the TLR4 activators FNEDA or tenascin-C induces joint inflammation in wild type but not in TLR4 null mice [24, 86].
Positive_regulation (activators) of Gene_expression (injection) of EDA in articular associated with inflammation and arthritis
1) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.59 Pain Relevance 0.48
Intra-articular injection of the TLR4 activators FNEDA or tenascin-C induces joint inflammation in wild type but not in TLR4 null mice [24, 86].
Neg (not) Positive_regulation (induces) of Gene_expression (injection) of EDA in articular associated with inflammation and arthritis
2) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.59 Pain Relevance 0.49
We observed that a single LPS injection elicited a specific change of PWTs while stimulated spinal glial activation was identified by immunoreactivities of specific markers, ED1, P2X4 receptor, endothelial monocyte activating polypeptide II (EMAP II) and glial fibrillary acidic protein (GFAP), respectively; multiple LPS treatments induced tolerance to mechanical hyperalgesia, whereas expression of ED1 and GFAP were further increased.
Positive_regulation (increased) of Gene_expression (expression) of ED1 in monocyte associated with hyperalgesia, tolerance and glial activation
3) Confidence 0.18 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 17021756 Disease Relevance 0.33 Pain Relevance 0.70
The results showed increased calpain expression in microglia (OX42) and infiltrating macrophages (ED1,2) in EAE compared to normal controls.
Positive_regulation (increased) of Gene_expression (expression) of ED1 in macrophages associated with multiple sclerosis
4) Confidence 0.05 Published 1998 Journal Brain Res. Section Abstract Doc Link 9518658 Disease Relevance 1.42 Pain Relevance 0.57

General Comments

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