INT74250

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 39.27
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
liver 14
plasma 10
blood 6
fat 6
muscle 2
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 611 100.00 Very High Very High Very High
electroacupuncture 82 99.84 Very High Very High Very High
Potency 2 97.40 Very High Very High Very High
hypoalgesia 4 96.76 Very High Very High Very High
cytokine 193 96.08 Very High Very High Very High
agonist 92 94.72 High High
Cholecystokinin 1 90.92 High High
Kinase C 52 88.56 High High
Paracetamol 37 88.40 High High
chemokine 43 87.48 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 774 100.00 Very High Very High Very High
INFLAMMATION 669 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 90 100.00 Very High Very High Very High
Repression 6 100.00 Very High Very High Very High
Diabetes Mellitus 670 99.92 Very High Very High Very High
Targeted Disruption 111 99.84 Very High Very High Very High
Obesity 1797 99.80 Very High Very High Very High
Body Weight 216 99.46 Very High Very High Very High
Weight Gain 104 99.46 Very High Very High Very High
Cardiovascular Disease 80 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the magnitudes of the [Ca2+]i drop and of the inhibition of insulin secretion produced by 250 micromol/l diazoxide were inversely related to the concentration of K+.
Negative_regulation (inhibition) of Gene_expression (produced) of insulin
1) Confidence 0.40 Published 1998 Journal Diabetes Section Abstract Doc Link 9519741 Disease Relevance 0 Pain Relevance 0
Interestingly, the ability of insulin to repress hepatic glucose production was significantly decreased in HFL and HFPS fed animals compared to HFP fed mice (figure 2).
Negative_regulation (decreased) of Gene_expression (production) of insulin in HFL
2) Confidence 0.36 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.27 Pain Relevance 0
In addition to an adverse metabolic phenotype, high dietary stearate levels decreased hepatic insulin sensitivity, characterized by a decreased repression of hepatic glucose production (figure 2) and impaired induction of hepatic PKBser473 phosphorylation by insulin (figure 3A).
Negative_regulation (decreased) of Gene_expression (sensitivity) of insulin associated with repression
3) Confidence 0.36 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.55 Pain Relevance 0
Collectively, and although insulin resistance may have favored ?
Negative_regulation (favored) of Gene_expression (resistance) of insulin associated with insulin resistance
4) Confidence 0.34 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.82 Pain Relevance 0
Pioglitazone reverses insulin resistance and impaired CCK-stimulated pancreatic secretion in eNOS(-/-) mice: therapy for exocrine pancreatic disorders?
Negative_regulation (reverses) of Gene_expression (resistance) of insulin associated with insulin resistance
5) Confidence 0.33 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17510194 Disease Relevance 0.24 Pain Relevance 0.05
In addition to an adverse metabolic phenotype, high dietary stearate levels decreased hepatic insulin sensitivity, characterized by a decreased repression of hepatic glucose production (figure 2) and impaired induction of hepatic PKBser473 phosphorylation by insulin (figure 3A).
Negative_regulation (decreased) of Gene_expression (sensitivity) of insulin associated with repression
6) Confidence 0.31 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.48 Pain Relevance 0
The major finding of this study included the following: (1) the increase in visceral adipose tissue preceded development of fatty liver and insulin resistance; (2) the increase in size of white adipocytes was an early event as the fist step to obesity; (3) adiponectin mRNA expression was markedly decreased before the decrease in its plasma levels or the development of insulin resistance; and (4) insulin resistance appeared in association with fatty infiltration and TNF-?
Negative_regulation (development) of Gene_expression (resistance) of insulin in plasma associated with fatty liver, obesity, metabolic syndrome and insulin resistance
7) Confidence 0.30 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.10 Pain Relevance 0.03
After two weeks of treatment, improved insulin sensitivity following EA treatment was demonstrated by reduced insulin levels in EA-treated mice that were subjected to overnight fasting.
Negative_regulation (reduced) of Gene_expression (levels) of insulin associated with electroacupuncture
8) Confidence 0.28 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.17 Pain Relevance 0.30
Insulin resistance can arise via different mechanisms e.g. mutations in genes encoding insulin signaling components or their reduced expression [31], [32].
Negative_regulation (reduced) of Gene_expression (expression) of insulin associated with insulin resistance
9) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.03 Pain Relevance 0.22
While these findings have provided compelling evidence for the immune response pathway to cause insulin resistance in liver, skeletal muscle and adipose tissue, the primary effect of insulin action and insulin resistance in cells of the innate immune system has been poorly investigated and remains controversial.
Negative_regulation (effect) of Gene_expression (resistance) of insulin in liver associated with obesity and insulin resistance
10) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.95 Pain Relevance 0.36
While these findings have provided compelling evidence for the immune response pathway to cause insulin resistance in liver, skeletal muscle and adipose tissue, the primary effect of insulin action and insulin resistance in cells of the innate immune system has been poorly investigated and remains controversial.
Negative_regulation (effect) of Gene_expression (resistance) of insulin in liver associated with obesity and insulin resistance
11) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.95 Pain Relevance 0.36
Myeloid cell-restricted insulin resistance does not affect obesity development upon high fat feeding
Negative_regulation (restricted) of Gene_expression (resistance) of insulin in Myeloid cell associated with obesity and insulin resistance
12) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.37 Pain Relevance 0.08
precede but strongly correlate with weight gain, body fat, and subsequent development of insulin resistance, supports a potential role of intestinal derived TNF-?
Negative_regulation (development) of Gene_expression (resistance) of insulin in fat associated with insulin resistance and weight gain
13) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.35 Pain Relevance 0.06
B in macrophages or liver attenuated inflammatory gene expression and insulin resistance on HF diet [31], c-Jun amino-terminal kinase 1 (JNK1) knockout mice do not become insulin resistant [32] while blocking JNK improves insulin sensitivity [33].
Negative_regulation (attenuated) of Gene_expression (resistance) of insulin in liver associated with targeted disruption, inflammation and insulin resistance
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.41 Pain Relevance 0.17
in small intestine precedes and correlates with the development of insulin resistance and obesity
Negative_regulation (development) of Gene_expression (resistance) of insulin in small intestine associated with obesity and insulin resistance
15) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.05 Pain Relevance 0.11
B in macrophages or liver attenuated inflammatory gene expression and insulin resistance on HF diet [31], c-Jun amino-terminal kinase 1 (JNK1) knockout mice do not become insulin resistant [32] while blocking JNK improves insulin sensitivity [33].
Negative_regulation (improves) of Gene_expression (sensitivity) of insulin in liver associated with targeted disruption, inflammation and insulin resistance
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922379 Disease Relevance 1.42 Pain Relevance 0.23
Baseline insulin levels did not differ between the groups, while the insulin response, as the glucagon response, was impaired after protein challenge (P = .018).
Negative_regulation (impaired) of Gene_expression (response) of insulin
17) Confidence 0.18 Published 2008 Journal Experimental Diabetes Research Section Abstract Doc Link PMC2443691 Disease Relevance 0.42 Pain Relevance 0.17
The

insulin response to protein ingestion was impaired in transgenic mice; the

Negative_regulation (impaired) of Gene_expression (response) of insulin associated with targeted disruption
18) Confidence 0.18 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2443691 Disease Relevance 0.74 Pain Relevance 0.24
In all the subjects fasting and post-lunch serum IGF-I concentrations were negatively correlated with age, blood glucose, insulin, C-peptide, triglycerides, and total lipid profile with an exception of HDL cholesterol and insulin resistance expressed as HOMA-IR.
Neg (exception) Negative_regulation (exception) of Neg (exception) Gene_expression (expressed) of insulin in blood associated with insulin resistance and disorder of lipid metabolism
19) Confidence 0.14 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 1.23 Pain Relevance 0.14
A plasma sample for determination of basal insulin levels was obtained during the final 10 min of the basal period and for steady-state insulin levels (47 ± 5 in Tg IRS-1 Ser?
Negative_regulation (determination) of Gene_expression (levels) of insulin in plasma
20) Confidence 0.12 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.06 Pain Relevance 0.03

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