INT74254

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Context Info
Confidence 0.36
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.37
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTPRC)
Anatomy Link Frequency
tube 1
smooth muscle 1
extracellular matrix 1
Memory T lymphocytes 1
PTPRC (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 126 98.68 Very High Very High Very High
Demyelination 123 97.68 Very High Very High Very High
imagery 96 96.48 Very High Very High Very High
positron emission tomography 51 95.92 Very High Very High Very High
agonist 2 92.28 High High
Multiple sclerosis 29 86.72 High High
Pain 23 82.48 Quite High
Inflammation 124 78.80 Quite High
abdominal pain 1 77.60 Quite High
backache 1 76.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 7 99.80 Very High Very High Very High
Cancer 330 99.76 Very High Very High Very High
Adenocarcinoma 5 99.32 Very High Very High Very High
Colon Cancer 40 98.24 Very High Very High Very High
Lymphatic System Cancer 8 97.76 Very High Very High Very High
Malignant Fibrous Histiocytoma 5 97.76 Very High Very High Very High
Demyelinating Disease 239 97.68 Very High Very High Very High
Adhesions 50 97.64 Very High Very High Very High
Cellulitis 1 96.56 Very High Very High Very High
Sprains And Strains 99 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expulsion and termination rates due to expulsion were higher with Cu T 200 and Cu T 380 A.
T 200 Binding (higher) of
1) Confidence 0.36 Published 1979 Journal J Obstet Gynaecol India Section Abstract Doc Link 12335926 Disease Relevance 0.15 Pain Relevance 0.15
Tumor cells were negative for cytokeratin, CD45, CD20, CD3, CD30, CD68, CD35 and CD1a; Ki-67 was positive in about 15% of the cells.
CD45 Binding (cytokeratin) of associated with cancer
2) Confidence 0.36 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2556649 Disease Relevance 0.62 Pain Relevance 0
Inhibition of viral proliferation by preventing interaction of viruses with their cellular receptor and their consequent signalling amplification systems, such as the tyrosine kinase p56lck, phosphatase CD45 and downstream ERK1/2, and the family of cytokines,88,89 is another approach.
CD45 Binding (interaction) of associated with cytokine
3) Confidence 0.35 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2519249 Disease Relevance 0.45 Pain Relevance 0.05
The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.
CD45 Binding (cytokeratin) of in smooth muscle
4) Confidence 0.26 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.83 Pain Relevance 0.07
For flow cytometry analysis the cells were detached with 0.05% trypsin/EDTA and washed with PBS. 1 × 105 cells per tube were blocked for 5 minutes with human AB serum (Sigma) and stained for 15 minutes incubated in an ice bath in the dark with direct PE or FITC conjugated mouse anti-human monoclonal antibodies (Becton Dickinson) recognizing CD11b, CD34, CD38, CD44, CD45, CD73, CD90, CD117 and HLA-DR.
CD45 Binding (recognizing) of in tube
5) Confidence 0.24 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
Immunostaining showed a positive marking for CD45, CD3.
CD45 Binding (marking) of
6) Confidence 0.24 Published 2010 Journal BMC Med Imaging Section Body Doc Link PMC2904264 Disease Relevance 0.75 Pain Relevance 0.08
Quantitatively, the major glandular product detected in maternal serum is a dimeric glycoprotein that is now referred to as glycodelin A, but has been termed PP14 and ?
glycoprotein Binding (dimeric) of
7) Confidence 0.03 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0 Pain Relevance 0
The sequence change at E2 aa115 and deletions at E2 aa116 and 119 in these neutralization-escape variant viruses indicate that F5 binds at this site in the E2 glycoprotein.
glycoprotein Binding (binds) of
8) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.29 Pain Relevance 0
Memory T lymphocytes were determined by UCHL1 indexed for CD45RO.


CD45RO Spec (determined) Binding (indexed) of in Memory T lymphocytes
9) Confidence 0.02 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2988071 Disease Relevance 0.05 Pain Relevance 0
Localisation of dystrophin to the sarcolemma suggests appropriate interaction with other proteins of the dystrophin glycoprotein complex.
glycoprotein Binding (interaction) of
10) Confidence 0.01 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.13 Pain Relevance 0
Adhesion in the presence of fibronectin was interpreted as the result of interaction with integrins as it is an extracellular matrix glycoprotein that binds to integrins.
matrix glycoprotein Binding (binds) of in extracellular matrix associated with adhesions
11) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.09 Pain Relevance 0
It has been found that glycoprotein-dependent and TLR2-indipendent innate immune recognition evokes a set of proinflammatory cytokines such as: TNF-?
glycoprotein Binding (recognition) of associated with cytokine
12) Confidence 0.01 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.19 Pain Relevance 0.16
It is a heterodimeric glycoprotein and interacts with cells and transmits signals through many receptors.
glycoprotein Binding (interacts) of
13) Confidence 0.01 Published 2010 Journal Journal of Periodontal & Implant Science Section Body Doc Link PMC2967808 Disease Relevance 0.16 Pain Relevance 0.03
In contrast, anti-TAG (tumor associated glycoprotein)-72 monoclonal antibodies are highly specific for binding to a variety of adenocarcinomas, including colorectal cancer.
glycoprotein Binding (binding) of associated with adenocarcinoma, cancer and colon cancer
14) Confidence 0.01 Published 2010 Journal World J Surg Oncol Section Abstract Doc Link PMC2924340 Disease Relevance 0.75 Pain Relevance 0.42
The critical role of the S glycoprotein in viral transport and subsequent axonal and myelin damage demonstrated in the current studies suggests that targeted disruption of the S glycoprotein-host interaction has the potential to prevent the onset or progression of demyelination.
glycoprotein-host Binding (interaction) of associated with targeted disruption and demyelination
15) Confidence 0.00 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 1.41 Pain Relevance 0.30
Characterization of a streptococcal antitumor glycoprotein (SAGP).
antitumor glycoprotein Binding (Characterization) of
16) Confidence 0.00 Published 1998 Journal Life Sci. Section Title Doc Link 9519806 Disease Relevance 0.49 Pain Relevance 0

General Comments

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