INT74260

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Context Info
Confidence 0.64
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.05
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serping1) extracellular region (Serping1) molecular_function (Serping1)
cellular_component (Serping1) biological_process (Serping1)
Serping1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 21 99.92 Very High Very High Very High
Inflammation 84 99.50 Very High Very High Very High
abdominal pain 3 94.16 High High
ischemia 3 76.84 Quite High
peptic ulcer disease 1 59.40 Quite High
Inflammatory marker 3 56.48 Quite High
cytokine 12 39.16 Quite Low
chemokine 9 15.32 Low Low
GABA receptor 3 9.68 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Retinopathy 96 100.00 Very High Very High Very High
Urticaria 15 99.84 Very High Very High Very High
INFLAMMATION 108 99.56 Very High Very High Very High
Hereditary Angioedema 10 97.72 Very High Very High Very High
Asphyxia 2 95.80 Very High Very High Very High
Laryngeal Edema 2 94.84 High High
Abdominal Pain 3 94.16 High High
Disease 9 92.80 High High
Adhesions 15 92.40 High High
Shock 3 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: An interruption of oral contraception induced an increase of the C1-INH level from 0.201 to 0.224 g/L (p < 0.002) and of the C1-INH functional assay fom 0.396 to 0.702 U (p < 0.0001), associated with a recovery or a marked improvement of the clinical symptoms formerly ascribed to food allergy.
Positive_regulation (increase) of C1-INH
1) Confidence 0.64 Published 2003 Journal Presse Med Section Body Doc Link 12870385 Disease Relevance 0 Pain Relevance 0
Mutations in the C1-inhibitor (C1-INH) gene, leading to low functional levels of C1-inhibitor protein, cause hereditary angioedema (HAE).
Positive_regulation (leading) of C1-inhibitor associated with hereditary angioedema
2) Confidence 0.50 Published 1998 Journal Scand. J. Immunol. Section Abstract Doc Link 9519866 Disease Relevance 0.69 Pain Relevance 0.08
Antigenic C1-INH values, however, are normal or increased owing to the presence of a dysfunctional protein from the mutated allele.
Positive_regulation (increased) of C1-INH
3) Confidence 0.50 Published 1998 Journal Scand. J. Immunol. Section Abstract Doc Link 9519866 Disease Relevance 0.80 Pain Relevance 0.09
However, the serum levels of complexed anti-C1INH antibodies were increased in CIU-infected subjects compared to CIU-noninfected subjects and healthy controls with an absorbance of 1.51 +/- 0.21 vs 1.36 +/- 0.16 and 1.26 +/- 0.23, respectively (P<0.05), indicating an impaired clearance of immune complexes in CIU-infected patients.
Positive_regulation (increased) of C1INH associated with urticaria
4) Confidence 0.46 Published 2004 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 14689038 Disease Relevance 1.50 Pain Relevance 0.06
C1-INH (complement component 1 inhibitor), also known as Serping1 [serine (or cysteine) peptidase inhibitor, clade G, member1], protein expression is increased in DR patients and C1-INH blocks the increased permeability caused by vitreal injection of carbonic anhydrase [13].
Positive_regulation (increased) of C1-INH associated with diabetic retinopathy
5) Confidence 0.17 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.31 Pain Relevance 0.21
Of the 15 inflammatory genes tested, 12 genes (C1-INH, CCR5, CD44, CHI3L1, HSPB1, JAK3, LGALS3, LGALS3BP, LAMA5, PEDF, STAT3, TIMP1) were reproducibly upregulated at 3 months (Figures 4 &5).
Positive_regulation (upregulated) of C1-INH associated with inflammation
6) Confidence 0.17 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.33 Pain Relevance 0.12
C1-INH (complement component 1 inhibitor), also known as Serping1 [serine (or cysteine) peptidase inhibitor, clade G, member1], protein expression is increased in DR patients and C1-INH blocks the increased permeability caused by vitreal injection of carbonic anhydrase [13].
Positive_regulation (increased) of C1-INH associated with diabetic retinopathy
7) Confidence 0.17 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.43 Pain Relevance 0.23

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