INT74262

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 7.51
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
anatomic regions 1
livers 1
brain structures 1
ACC 1
lens 1
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 5 99.40 Very High Very High Very High
Inflammation 81 99.16 Very High Very High Very High
Inflammatory response 19 99.16 Very High Very High Very High
tetrodotoxin 1 98.90 Very High Very High Very High
cytokine 20 98.64 Very High Very High Very High
long-term potentiation 24 97.84 Very High Very High Very High
Hippocampus 42 97.76 Very High Very High Very High
IPN 4 88.56 High High
fluoxetine 4 87.08 High High
withdrawal 6 86.88 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 64 99.96 Very High Very High Very High
INFLAMMATION 94 99.16 Very High Very High Very High
Stress 58 98.68 Very High Very High Very High
Repression 6 98.56 Very High Very High Very High
Aids-related Complex 71 97.76 Very High Very High Very High
Sprains And Strains 64 96.10 Very High Very High Very High
Hypoxia 8 95.12 Very High Very High Very High
Acute-phase Reaction 3 92.40 High High
Nociception 3 92.32 High High
Inflammatory Pain 4 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Egr-1 mRNA level in the eyes of treated animals was remarkably reduced when compared to that in the control group.
Negative_regulation (reduced) of Egr-1 mRNA in eyes
1) Confidence 0.57 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.06 Pain Relevance 0
In contrast to the strain-independent effect of early life stress on GR expression, however, changes in egr-1 expression occurred only in Balb/c mice, and unlike the biphasic developmental changes in GR mRNA expression, egr-1 mRNA was decreased throughout postnatal development.
Negative_regulation (decreased) of egr-1 associated with stress and sprains and strains
2) Confidence 0.57 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.07 Pain Relevance 0.19
Downregulation of Egr1 may be of significance to c-Met phenotype since Egr1 is reported to be a transcriptional target of HGF, and Egr1-null mice display a delayed mitotic progression through defective spindle assembly checkpoint [21].
Negative_regulation (Downregulation) of Egr1 in HGF
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.13 Pain Relevance 0
livers displayed downregulation of Egr-1, an immediate early growth response gene shown to be involved in the control of mitotic entry through the spindle assembly checkpoint [21].
Negative_regulation (downregulation) of Egr-1 in livers
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
Further, studies in mutant mice have demonstrated that Egr1 inactivation prevents the maintenance of synaptic plasticity in the hippocampus and severely impairs the consolidation and reconsolidation of several types of long-term memories (Bozon et al., 2002; Bozon et al., 2003a; Bozon et al., 2003b; Jones et al., 2001).
Negative_regulation (inactivation) of Egr1 in hippocampus associated with hippocampus
5) Confidence 0.43 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.22
Last, synaptic potentiation induced by theta (theta) burst stimulation in the ACC was significantly reduced or blocked in Egr1 knockout mice.
Negative_regulation (blocked) of Egr1 in ACC associated with targeted disruption and anterior cingulate cortex
6) Confidence 0.43 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 1.44 Pain Relevance 0.83
As opposed to Egr1, however, which is rapidly induced in different brain structures after a variety of learning (Guzowski et al., 2001; Hall et al., 2001; Malkani and Rosen, 2000; Maviel et al., 2004; Okuno and Miyashita, 1996; Thomas et al., 2002), there is as yet no firm evidence for Egr2 induction after learning, at least in fear conditioning (Malkani and Rosen, 2000).
Negative_regulation (opposed) of Egr1 in brain structures associated with anxiety disorder
7) Confidence 0.42 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.40 Pain Relevance 0.30
Finally, Egr proteins also possess a domain for transcriptional repression mediated by the repressor proteins Nab1 and Nab2 that binds to and can repress Egr function (Russo et al., 1995; Svaren et al., 1996; Swirnoff et al., 1998).
Negative_regulation (repress) of Egr associated with repression
8) Confidence 0.42 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.10 Pain Relevance 0
Mice lacking functional copies of Egr1 and Nr4a1 (nur77) do not show altered circadian rhythms, suggesting that these genes do not play an important role in entrainment [10], although there could be compensatory mechanisms in the knockout mice that mask the role of these genes.
Negative_regulation (lacking) of Egr1 associated with targeted disruption
9) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.18 Pain Relevance 0.04
Many immediate early genes such as Fos, Jun and Early Growth Response isoforms were down-regulated although others associated with stress such as glucocorticoid responsive genes were up-regulated.
Negative_regulation (regulated) of Early Growth Response associated with stress
10) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2939656 Disease Relevance 0.45 Pain Relevance 0.06
For example, using a gene array (588 genes) designed for analysis of transcription factors, Landenberg et al demonstrated a 2-fold or greater up-regulation of six genes, including early-growth response gene-1 (Egr-1), Nurr77, tristetraprolin, the inhibitor of kB-alpha (IkB-alpha), Klf-4 (GKLF) and LRG-21, all within two hours of pneumonectomy in mice [9].
Negative_regulation (inhibitor) of Egr-1
11) Confidence 0.35 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.14 Pain Relevance 0
Some of the early events—for example, ZENK expression changes—may persist after one day of lens treatment (ZENK mRNA level remains low after one day of negative lens treatment) or even reverse the direction of changes (ZENK mRNA levels are upregulated by short periods of positive lens wear [19] but seem to be downregulated by longer periods of positive lens treatment [41]).
Negative_regulation (downregulated) of ZENK in lens
12) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0
On the other hand, down-regulation of EGR1, a master switch of inflammatory responses prompted by oxidative stress [103], counteracts angiogenesis, thus increasing hypoxic conditions, but has an anti-inflammatory effect.
Negative_regulation (regulation) of EGR1 associated with stress, inflammatory response, inflammation and hypoxia
13) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.53 Pain Relevance 0.31
Moreover, there was no consistent overlap of anatomic regions affected by decreased GR and egr-1 protein expression.
Negative_regulation (decreased) of egr-1 in anatomic regions
14) Confidence 0.18 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.98 Pain Relevance 0.19
The top network in the B6 GMA-SS-exposed lung consisted primarily of decreased gene expression for dual specificity phosphatase 1 (DUSP1), a downregulator of MAPK signaling, transcriptional regulators EGR1, FOS, FOSB, and pro-inflammatory cytokine IL1?
Negative_regulation (downregulator) of EGR1 in lung associated with inflammation, aids-related complex and cytokine
15) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.04 Pain Relevance 0.17
Nevertheless, we found, in adult marmosets, 24 hours after monocular retinal activity blockade by tetrodotoxin, distinct alternating compartments of potentiated and depressed Krox-24-like immunoreactivity (Krox-IR) in layer IV of area 17.
Negative_regulation (depressed) of Krox-IR associated with tetrodotoxin
16) Confidence 0.01 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9520106 Disease Relevance 0 Pain Relevance 0.10

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