INT74272

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Context Info
Confidence 0.63
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 39
Total Number 39
Disease Relevance 25.12
Pain Relevance 10.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
PGE2 3
stromal cells 3
microglia 2
macrophages 1
SK-N-SH 1
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 355 100.00 Very High Very High Very High
COX-2 inhibitor 107 100.00 Very High Very High Very High
Inflammation 483 98.82 Very High Very High Very High
Pain 27 98.60 Very High Very High Very High
Inflammatory response 40 97.80 Very High Very High Very High
ischemia 8 97.68 Very High Very High Very High
Paracetamol 21 95.96 Very High Very High Very High
cytokine 186 95.84 Very High Very High Very High
Inflammatory stimuli 10 95.20 Very High Very High Very High
withdrawal 2 94.60 High High
Disease Link Frequency Relevance Heat
Adhesions 31 99.62 Very High Very High Very High
Reprotox - General 1 162 99.28 Very High Very High Very High
Neuroblastoma 25 99.04 Very High Very High Very High
Airway Obstruction 2 98.88 Very High Very High Very High
INFLAMMATION 598 98.82 Very High Very High Very High
Disease 318 98.76 Very High Very High Very High
Sepsis 53 98.70 Very High Very High Very High
Pain 27 98.60 Very High Very High Very High
Pressure And Volume Under Development 18 98.24 Very High Very High Very High
Asthma 100 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, COX-2 was localized primarily in tumor cells but also appeared in stromal cells.
Localization (localized) of COX in stromal cells
1) Confidence 0.63 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical staining of specimens that expressed COX-1 and/or COX-2 revealed that COX-1 was localized in stromal cells adjacent to the tumor but not in tumor cells.
Localization (localized) of COX in stromal cells
2) Confidence 0.59 Published 1998 Journal J. Natl. Cancer Inst. Section Body Doc Link 9521170 Disease Relevance 0.07 Pain Relevance 0
However, in situations where the release of protective PGs by COX-1 has been lost, the induction of COX-2 may compensate and reduce inflammatory responses.
Localization (release) of COX associated with inflammatory response
3) Confidence 0.50 Published 1998 Journal Inflamm. Res. Section Abstract Doc Link 9831329 Disease Relevance 0.55 Pain Relevance 0.26
This is particularly likely in large blood vessels, where, under physiological conditions, the release of prostacyclin by COX-1, present in the endothelium, is an important component of cardiovascular homeostasis.
Localization (release) of COX in endothelium
4) Confidence 0.44 Published 1998 Journal Inflamm. Res. Section Abstract Doc Link 9831329 Disease Relevance 0.58 Pain Relevance 0.30
COX isotype selective inhibitors were used to discern relative contributions of COX-1 and COX-2 activities to microglial PGE(2) secretion.
Localization (secretion) of COX
5) Confidence 0.39 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.63 Pain Relevance 0.29
COX isotype selective inhibitors were used to discern relative contributions of COX-1 and COX-2 activities to microglial PGE(2) secretion.
Localization (secretion) of COX
6) Confidence 0.39 Published 2002 Journal Brain Res. Section Abstract Doc Link 12270500 Disease Relevance 0.63 Pain Relevance 0.29
Here we show that interleukin (IL)-1beta induces COX-2 mRNA and protein synthesis and the release of PGE(2) in the human neuroblastoma cell line SK-N-SH.
Localization (release) of COX in SK-N-SH associated with neuroblastoma
7) Confidence 0.35 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.52 Pain Relevance 0.13
The IC50-values obtained for the inhibition of lipopolysaccharide (LPS)-induced release of prostaglandin E2 (PGE2) reflecting cyclooxygenase (COX)-2-mediated PGE2 release were 47 microg/ml and 0.6 microg/ml, for the Salix extract 1520L and rofecoxib-like research compound L745337, respectively.
Localization (release) of COX in PGE2
8) Confidence 0.32 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.40 Pain Relevance 0.25
Our results indicate that Salix extract 1520L inhibits COX-2-mediated PGE2 release through compounds other than salicin or salicylate.
Localization (release) of COX in PGE2
9) Confidence 0.28 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.38 Pain Relevance 0.24
The IC50-values obtained for the inhibition of lipopolysaccharide (LPS)-induced release of prostaglandin E2 (PGE2) reflecting cyclooxygenase (COX)-2-mediated PGE2 release were 47 microg/ml and 0.6 microg/ml, for the Salix extract 1520L and rofecoxib-like research compound L745337, respectively.
Localization (release) of COX in PGE2
10) Confidence 0.28 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15070163 Disease Relevance 0.40 Pain Relevance 0.25
Another factor might be the different intracellular localization of the two COX isoforms, which might lead to (unknown) alternative effects of the same prostaglandin products [43].
Localization (localization) of COX
11) Confidence 0.27 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526565 Disease Relevance 0.67 Pain Relevance 0.62
Inhibition of PAP-1 by bromoenol lactone, propranolol, or ethanol resulted in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E(2) release from U937 macrophages.
Localization (release) of COX in macrophages
12) Confidence 0.25 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16950767 Disease Relevance 0.08 Pain Relevance 0.08
Another factor might be the different intracellular localization of the two COX isoforms, which might lead to (unknown) alternative effects of the same prostaglandin products [43].
Localization (localization) of COX
13) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526565 Disease Relevance 0.67 Pain Relevance 0.62
Following impact, both control and loaded explants were re-cultured in fresh medium (1 ml per explant) for 6 days in the presence of either the selective COX-2 inhibitor celecoxib (donated by Pfizer Inc., New York, USA; 0.01, 0.1, 1.0 and 10 ?
Localization (presence) of COX associated with cox-2 inhibitor
14) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246251 Disease Relevance 0.09 Pain Relevance 0.10
Following impact, both control and loaded explants were re-cultured in fresh medium (1 ml per explant) for 6 days in the presence of either the selective COX-2 inhibitor celecoxib (donated by Pfizer Inc., New York, USA; 0.01, 0.1, 1.0 and 10 ?
Localization (selective) of COX associated with cox-2 inhibitor
15) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246251 Disease Relevance 0.09 Pain Relevance 0.10
The typical target of NSAIDs is cyclooxygenase (COX).
Localization (target) of COX associated with cinod
16) Confidence 0.19 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.00 Pain Relevance 0.64
Co-localization of COX-2-positive stromal cells was seen with CD68, alpha-smooth muscle actin (alpha-SMA), vimentin, and HLA-DR, but an as yet unidentified subpopulation of stromal cells remained.
Localization (Co-localization) of COX in stromal cells
17) Confidence 0.17 Published 2002 Journal J. Pathol. Section Abstract Doc Link 11793368 Disease Relevance 0.71 Pain Relevance 0.13
Kirschenbaum and colleagues (2000) reported both COX-1 and COX-2 expressions in PC tissues were stronger than those in NP tissues by immunohistochemical staining.
Localization (reported) of COX associated with reprotox - general 1
18) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 2.34 Pain Relevance 0.08
Kirschenbaum and colleagues (2000) reported both COX-1 and COX-2 expressions in PC tissues were stronger than those in NP tissues by immunohistochemical staining.
Localization (reported) of COX associated with reprotox - general 1
19) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 2.33 Pain Relevance 0.08
The typical target of NSAIDs is cyclooxygenase (COX).
Localization (target) of COX associated with cinod
20) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.20 Pain Relevance 0.70

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