INT74286

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2011
Negated 8
Speculated 6
Reported most in Body
Documents 42
Total Number 48
Disease Relevance 28.06
Pain Relevance 19.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
plasma 5
spinal cord 2
cerebrospinal fluid 1
brain 1
regulatory T cells 1
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 352 100.00 Very High Very High Very High
cytokine 325 100.00 Very High Very High Very High
Pain 61 100.00 Very High Very High Very High
Inflammatory response 51 100.00 Very High Very High Very High
Catecholamine 21 100.00 Very High Very High Very High
analgesia 6 100.00 Very High Very High Very High
COX2 2 100.00 Very High Very High Very High
acular 6 99.84 Very High Very High Very High
antidepressant 6 99.82 Very High Very High Very High
Eae 122 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 414 100.00 Very High Very High Very High
Necrosis 45 100.00 Very High Very High Very High
Cancer 43 100.00 Very High Very High Very High
Obesity 40 100.00 Very High Very High Very High
Injury 228 99.80 Very High Very High Very High
Pain 67 99.80 Very High Very High Very High
Neuropathic Pain 158 99.64 Very High Very High Very High
Disorders Of Creatine Metabolism 21 99.58 Very High Very High Very High
Pancreatitis 82 99.12 Very High Very High Very High
Functional Bowel Disorder 2 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat.
Regulation (Effects) of interleukin-10 in spinal cord associated with pain, cox2 and spinal cord
1) Confidence 0.44 Published 2001 Journal Exp. Neurol. Section Title Doc Link 11170729 Disease Relevance 1.35 Pain Relevance 0.83
Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat.
Regulation (Effects) of IL-10 in spinal cord associated with pain, cox2 and spinal cord
2) Confidence 0.44 Published 2001 Journal Exp. Neurol. Section Title Doc Link 11170729 Disease Relevance 1.36 Pain Relevance 0.83
To further characterize the onset and progression of this behavior we evaluated the effects of 3 drugs, agmatine (Agm), interleukin-10 (IL-10), and cyclosporin A (CsA), on different characteristics of this behavior.
Regulation (effects) of interleukin-10
3) Confidence 0.41 Published 2003 Journal J Pain Section Abstract Doc Link 14622710 Disease Relevance 0.34 Pain Relevance 0.33
To further characterize the onset and progression of this behavior we evaluated the effects of 3 drugs, agmatine (Agm), interleukin-10 (IL-10), and cyclosporin A (CsA), on different characteristics of this behavior.
Regulation (effects) of IL-10
4) Confidence 0.41 Published 2003 Journal J Pain Section Abstract Doc Link 14622710 Disease Relevance 0.34 Pain Relevance 0.33
BACKGROUND: Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin-6 and interleukin-10.
Regulation (regulating) of interleukin-10 associated with cytokine
5) Confidence 0.30 Published 2007 Journal Akush Ginekol (Sofiia) Section Abstract Doc Link 17469457 Disease Relevance 0 Pain Relevance 0.12
Significant changes of IL-10 protein levels were also induced in C7-C8 DRG by the unilateral CCI of the sciatic nerve.
Regulation (changes) of IL-10 in sciatic nerve associated with eae and sciatic nerve
6) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.62 Pain Relevance 0.43
No changes of the IL-10 protein levels were found in C7-C8 DRG of the sham-operated rats after 3 and 14 days.


Neg (No) Regulation (changes) of IL-10
7) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.41 Pain Relevance 0.24
Its effect on IL-10 bioactivity in vitro, if any, is currently under investigation



Regulation (effect) of IL-10
8) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079940 Disease Relevance 0 Pain Relevance 0
However, interpersonal differences in the regulation of IL-10 and TNF-?
Regulation (regulation) of IL-10
9) Confidence 0.25 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2745565 Disease Relevance 0.85 Pain Relevance 0.28
Plasma levels of interleukin-6 and interleukin-10 are affected by ketorolac as an adjunct to patient-controlled morphine after abdominal hysterectomy.
Regulation (affected) of interleukin-10 in Plasma associated with acular and morphine
10) Confidence 0.24 Published 2001 Journal Clin J Pain Section Title Doc Link 11289091 Disease Relevance 0 Pain Relevance 1.09
Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome.
Regulation (Role) of interleukin-10 in bowel associated with necrosis, cancer and spastic colon
11) Confidence 0.24 Published 2005 Journal Am. J. Gastroenterol. Section Title Doc Link 16279907 Disease Relevance 0.84 Pain Relevance 0.76
Through a systematic comparison of the effects of IL-10, fluorocitrate and minocycline on masseter and cutaneous hyperalgesia, we further demonstrate a selective involvement of the trigeminal Vi/Vc transition zone in response to deep orofacial tissue injury.
Regulation (effects) of IL-10 in masseter associated with hyperalgesia and injury
12) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.01 Pain Relevance 0.95
In conclusion, the frequency differences in this study highlight the significance and biological relevance of genetic factors, IL-10, MBL and Fas regulation among women with acute chorioamnionitis and adverse pregnancy outcome.


Regulation (regulation) of IL-10 associated with chorioamnionitis
13) Confidence 0.21 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 0.36 Pain Relevance 0
PGE2 may exert anti-inflammatory effect via its influence on IL-10 production [36].
Regulation (influence) of IL-10 associated with inflammation
14) Confidence 0.21 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.44 Pain Relevance 0.22
In order to understand the possible antinocicieptive effect of pentoxifylline in neuropathic pain, we examined the level of TNFalpha, IL-1beta, IL-6 and IL-10 protein in the contralateral brain on day 7 post-transection.
Spec (examined) Regulation (level) of IL-10 in brain associated with neuropathic pain
15) Confidence 0.17 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17140731 Disease Relevance 0.49 Pain Relevance 0.68
The concentrations of TP, ALB and level of IL-10 in intestine in group M decreased significantly while the concentrations of S/L, LDH and the levels of IL-6 and TNF-?
Regulation (concentrations) of IL-10 in intestine
16) Confidence 0.17 Published 2008 Journal BMC Gastroenterol Section Abstract Doc Link PMC2564972 Disease Relevance 0.38 Pain Relevance 0.11
Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma.
Regulation (Effect) of interleukin-10 associated with necrosis, cancer, catecholamine and injury
17) Confidence 0.17 Published 2008 Journal Vascul. Pharmacol. Section Title Doc Link 18234565 Disease Relevance 0.83 Pain Relevance 0.46
However, endurance exercise programs induce an anti-inflammatory response in the adipose tissue and increase IL-10 levels, leading to a protective effect [10].
Regulation (response) of IL-10 in adipose tissue associated with inflammatory response and obesity
18) Confidence 0.15 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 1.17 Pain Relevance 0.30
We investigated the influence of interleukin 10 (IL10) and tumour necrosis factor alpha (TNFalpha) promotor variants on the manifestation of chronic pancreatitis of different underlying causes and in pancreatic cancer.
Spec (investigated) Regulation (influence) of interleukin 10 associated with necrosis, cancer, pancreatic cancer and chronic pancreatitis
19) Confidence 0.15 Published 2003 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 14560157 Disease Relevance 0.81 Pain Relevance 0.17
We investigated the influence of interleukin 10 (IL10) and tumour necrosis factor alpha (TNFalpha) promotor variants on the manifestation of chronic pancreatitis of different underlying causes and in pancreatic cancer.
Spec (investigated) Regulation (influence) of IL10 associated with necrosis, cancer, pancreatic cancer and chronic pancreatitis
20) Confidence 0.15 Published 2003 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 14560157 Disease Relevance 0.81 Pain Relevance 0.17

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