INT743

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Context Info
Confidence 0.57
First Reported 1977
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 8.75
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nasal 1
Salpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 6 100.00 Very High Very High Very High
Pain 29 99.70 Very High Very High Very High
Osteoarthritis 3 99.28 Very High Very High Very High
rheumatoid arthritis 3 98.64 Very High Very High Very High
spinal inflammation 1 97.60 Very High Very High Very High
Inflammation 6 95.32 Very High Very High Very High
palliative 1 94.64 High High
withdrawal 1 84.96 Quite High
cINOD 3 79.64 Quite High
Arthritis 2 75.16 Quite High
Disease Link Frequency Relevance Heat
Muscle Disease 2 99.96 Very High Very High Very High
Pain 20 99.70 Very High Very High Very High
Osteoarthritis 3 99.28 Very High Very High Very High
Disease 17 99.26 Very High Very High Very High
Rheumatoid Arthritis 3 98.64 Very High Very High Very High
Body Weight 6 98.44 Very High Very High Very High
Low Back Pain 1 97.60 Very High Very High Very High
Metastasis 2 97.24 Very High Very High Very High
Death 2 96.00 Very High Very High Very High
Bone Disease 15 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum alkaline phosphatase (Al.Ph.) and urinary hydroxyproline/creatinine excretion (HOP/Cr) were reduced after each sequence.
Negative_regulation (reduced) of Serum alkaline phosphatase
1) Confidence 0.57 Published 1992 Journal Bone Miner Section Abstract Doc Link 1422319 Disease Relevance 0.55 Pain Relevance 0.21
It significantly reduces the serum alkaline phosphatase in patients with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Negative_regulation (reduces) of serum alkaline phosphatase associated with spinal inflammation, rheumatoid arthritis and osteoarthritis
2) Confidence 0.56 Published 1982 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 7044796 Disease Relevance 0.39 Pain Relevance 0.24
In patients with Paget's disease, pain diminished or disappeared and serum alkaline phosphatase levels decreased after treatment with oral risedronate 30 mg/day for < or = 3 months.
Negative_regulation (decreased) of serum alkaline phosphatase associated with pain and disease
3) Confidence 0.56 Published 1998 Journal Drugs Aging Section Abstract Doc Link 9679211 Disease Relevance 0.70 Pain Relevance 0.30
The alendronate-treated group had significantly greater decreases in both serum alkaline phosphatase (79% vs. 44%) and urinary deoxypyridinoline (75% vs. 51%) than the etidronate-treated group (P < 0.001 in both cases).
Negative_regulation (decreases) of serum alkaline phosphatase
4) Confidence 0.56 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8772558 Disease Relevance 0.53 Pain Relevance 0.09
Effective suppression of bone turnover was assessed by monitoring the reduction in serum alkaline phosphatase and the ratio of urinary hydroxyproline/creatinine.
Negative_regulation (reduction) of serum alkaline phosphatase
5) Confidence 0.56 Published 1995 Journal Bone Section Abstract Doc Link 8573426 Disease Relevance 0.38 Pain Relevance 0.15
19 patients with Paget's disease were treated orally for 6 months with disodium dichloromethylene diphosphonate. 1600 mg/day (10 patients) significantly reduced urine hydroxyproline, serum alkaline phosphatase, urine calcium, and the number of pagetic bone osteoclasts.
Negative_regulation (reduced) of serum alkaline phosphatase associated with disease
6) Confidence 0.56 Published 1979 Journal Lancet Section Abstract Doc Link 90215 Disease Relevance 0.26 Pain Relevance 0.08
Therapy with calcitriol (1 alpha, 25-dihydroxycholecalciferol) lad to clinical improvement in seven patients with reduced pain and myopathy, decreased serum alkaline phosphatase, or both, but no improvement in bone histology.
Negative_regulation (decreased) of serum alkaline phosphatase associated with pain and muscle disease
7) Confidence 0.56 Published 1981 Journal Ann. Intern. Med. Section Abstract Doc Link 6894520 Disease Relevance 1.21 Pain Relevance 0.10
Significant decreases in serum alkaline phosphatase and urinary hydroxyproline were noted after 6 months of therapy; no significant further improvement resulted after prolonged therapy.
Negative_regulation (decreases) of serum alkaline phosphatase
8) Confidence 0.56 Published 1977 Journal Ann. Intern. Med. Section Abstract Doc Link 412450 Disease Relevance 0.58 Pain Relevance 0.10
In all cases was observed significant reductions in increased serum alkaline phosphatase.
Negative_regulation (reductions) of serum alkaline phosphatase
9) Confidence 0.29 Published 1978 Journal ZFA Section Abstract Doc Link 570764 Disease Relevance 0.37 Pain Relevance 0.14
In the ovariectomized rats, diacerein (10, 100 mg/kg/day) also significantly prevented bone loss and reduced the serum alkaline phosphatase and decreased the excretion of urinary hydroxyproline.
Negative_regulation (reduced) of serum alkaline phosphatase
10) Confidence 0.28 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12126975 Disease Relevance 1.10 Pain Relevance 0.54
After 1 year of nasal calcitonin the reduction in serum alkaline phosphatase was 24%, and in urinary hydroxyproline 10%.
Negative_regulation (reduction) of serum alkaline phosphatase in nasal
11) Confidence 0.22 Published 1995 Journal Harefuah Section Abstract Doc Link 7750816 Disease Relevance 0.35 Pain Relevance 0.18
Serum alkaline phosphatase levels decreased significantly.
Negative_regulation (decreased) of Serum alkaline phosphatase
12) Confidence 0.21 Published 2004 Journal Turk. J. Pediatr. Section Abstract Doc Link 15641265 Disease Relevance 0.49 Pain Relevance 0.10
The level of serum alkaline phosphatase decreased in 11 of 18 patients and that of acid phosphatase in 8 of 16 patients.
Negative_regulation (decreased) of serum alkaline phosphatase
13) Confidence 0.18 Published 1988 Journal Eur. Urol. Section Abstract Doc Link 3360030 Disease Relevance 0.69 Pain Relevance 0.27
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for 2 days) prevented (P < 0.001) the paracetamol (640 mg/kg)-induced rise in serum enzymes alkaline phosphatase (ALP) and transaminases (GOT and GPT), whereas the same dose of the extract was unable to prevent (P > 0.05) the CCI4-induced rise in serum enzyme levels. 4.
Negative_regulation (prevented) of serum enzymes alkaline phosphatase associated with paracetamol
14) Confidence 0.16 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8909978 Disease Relevance 0.17 Pain Relevance 0.43
Improvement was indicated by alleviation of symptoms and reduction in serum alkaline phosphatase and urinary hydroxyproline.
Negative_regulation (reduction) of serum alkaline phosphatase
15) Confidence 0.13 Published 1980 Journal Arthritis Rheum. Section Abstract Doc Link 6775644 Disease Relevance 0.16 Pain Relevance 0
In ten cases preoperative PTBD reduced serum bilirubin (P less than 0.01), serum alkaline phosphatase (P less than 0.05), and lactic dehydrogenase (P less than 0.01) levels after 12 +/- 5 days, and resulted in minimal operative morbidity and mortality.
Negative_regulation (reduced) of serum alkaline phosphatase
16) Confidence 0.13 Published 1982 Journal Med. J. Aust. Section Abstract Doc Link 6178007 Disease Relevance 0.25 Pain Relevance 0.09
Treatment with calcitonin, etidronate and vitamin D resulted in partial clinical improvement, reduction of abnormal isotope hyperfixation in bone scintigraphy and of serum alkaline phosphatase levels.
Spec (partial) Negative_regulation (reduction) of serum alkaline phosphatase
17) Confidence 0.07 Published 1998 Journal Rev Med Chil Section Abstract Doc Link 10030095 Disease Relevance 0.57 Pain Relevance 0.07

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