INT74306

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Context Info
Confidence 0.24
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.93
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pik3cd) signal transduction (Pik3cd) kinase activity (Pik3cd)
Anatomy Link Frequency
spinal 1
neuronal 1
neural 1
Pik3cd (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.74 Very High Very High Very High
Morphine 5 99.48 Very High Very High Very High
Kappa opioid receptor 2 99.34 Very High Very High Very High
withdrawal 5 99.12 Very High Very High Very High
antidepressant 4 98.72 Very High Very High Very High
dorsal root ganglion 1 98.06 Very High Very High Very High
MU agonist 2 94.32 High High
narcan 3 93.92 High High
intrathecal 1 89.24 High High
cytokine 8 88.92 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 98.06 Very High Very High Very High
Neuroblastoma 3 97.60 Very High Very High Very High
Apoptosis 82 96.60 Very High Very High Very High
Cancer 76 88.72 High High
Neurodegenerative Disease 7 82.96 Quite High
Disease 62 82.24 Quite High
Severe Combined Immunodeficiency 7 80.96 Quite High
Hepatocellular Cancer 36 75.00 Quite High
Liver Cancer 12 68.72 Quite High
Stress 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the spinal phosphoinositide 3-kinase exacerbates morphine withdrawal response.
Negative_regulation (Inhibition) of phosphoinositide 3-kinase in spinal associated with withdrawal and morphine
1) Confidence 0.24 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16806705 Disease Relevance 0 Pain Relevance 0.81
No effect of selective inhibitors of p38-MAPK, phosphatidylinositol 3-kinase (PI3-K)/Akt, and glycogen synthase kinase (GSK-3) on the imipramine-induced inhibition of GR function was detected.
Negative_regulation (inhibitors) of phosphatidylinositol 3-kinase
2) Confidence 0.18 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.07 Pain Relevance 0.34
Apoptosis was induced in both primary neuronal cultures from embryonic day 7 cerebral hemispheres of chick brain (E7CH) and the F-11kappa7 cell line (an immortalized mouse neuroblastoma x dorsal root ganglion hybrid stably transfected to overexpress kappa-opioid receptors) by either staurosporine or the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002.
Negative_regulation (inhibitors) of phosphatidylinositol 3-kinase in neuronal associated with ganglion cysts, dorsal root ganglion, neuroblastoma, kappa opioid receptor and apoptosis
3) Confidence 0.13 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9523553 Disease Relevance 0.70 Pain Relevance 0.53
The SNC80-induced neural differentiation was also inhibited by treatment with the protein kinase C (PKC) inhibitor, phosphatidylinositol 3-kinase (PI3K) inhibitor, mitogen-activated protein kinase kinase (MEK) inhibitor or Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor.
Negative_regulation (inhibitor) of phosphatidylinositol 3-kinase in neural associated with kinase c
4) Confidence 0.13 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16696856 Disease Relevance 0.21 Pain Relevance 0.55
Furthermore, global inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production.
Negative_regulation (inhibition) of phosphatidylinositol-3 kinase
5) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.08 Pain Relevance 0.04
The cultured HUVECs were treated with or without 100 IU/ml EPO for 48 hours, and then exposed for 3 hours to (a) 0.25 mg/ml bevacizumab, (b) 100 nM of PD173074; an inhibitor of bFGF (Calbiochem, San Diego, CA), (c) 20 ┬ÁM of tyrphostin AG 1296; a selective inhibitor of PDGF (sigma), (d) a combination of bevacizumab, PD173074 and tyrphostin, and to (e) 100 nM wortmannin; a phosphatidylinositol 3-kinaz (PI 3-K) inhibitor (sigma).
Negative_regulation (inhibitor) of PI 3-K
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0 Pain Relevance 0
Inhibition of phosphatidylinositol 3-kinase (PI-3K), c-Jun N-terminal kinase (JNK) and p38 kinase activities caused only a mild apoptosis in HepG2 and Hep3B cells.
Negative_regulation (Inhibition) of phosphatidylinositol 3-kinase associated with apoptosis
7) Confidence 0.02 Published 2003 Journal BMC Gastroenterol Section Abstract Doc Link PMC317301 Disease Relevance 0.87 Pain Relevance 0

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