INT74324

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.91
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
visceral 2
colons 2
thalamus 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 1 99.98 Very High Very High Very High
antagonist 1 99.16 Very High Very High Very High
spastic colon 5 94.80 High High
Enkephalin 5 93.20 High High
qutenza 2 92.32 High High
Visceral pain 3 83.16 Quite High
Nerve growth factor 1 45.04 Quite Low
Pain 1 25.00 Low Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 21 99.98 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

14 99.76 Very High Very High Very High
Sprains And Strains 4 99.16 Very High Very High Very High
Functional Bowel Disorder 5 94.80 High High
Gastrointestinal Disease 2 90.28 High High
Hypertension 3 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 72.60 Quite High
Neuroleptic Malignant Syndrome 2 62.96 Quite High
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A MEDLINE search of the years 1981 to 2005 was conducted using the key words stress, CRF, CRH, CRF1 receptor, IBS, CRD, female rat, visceral pain, estrogen, and anxiety.
Positive_regulation (conducted) of Gene_expression (using) of CRF1 in visceral
1) Confidence 0.49 Published 2005 Journal Gender medicine : official journal of the Partnership for Gender-Specific Medicine at Columbia University Section Body Doc Link 16290887 Disease Relevance 0.08 Pain Relevance 0
Furthermore, an increased expression of CRF type 1 receptor (CRF-R1) was observed in the thalamus of NMS rats.
Positive_regulation (increased) of Gene_expression (expression) of CRF type 1 receptor in thalamus
2) Confidence 0.45 Published 2010 Journal Neuro Endocrinol. Lett. Section Body Doc Link 20424584 Disease Relevance 0.13 Pain Relevance 0
Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in rat.
Positive_regulation (elevates) of Gene_expression (expression) of corticotrophin releasing factor type 1 receptor
3) Confidence 0.45 Published 2010 Journal Neuro Endocrinol. Lett. Section Title Doc Link 20424584 Disease Relevance 0.28 Pain Relevance 0.18
Exposure to open field (OF) and colorectal distension (CRD) stressors induced decreased protein expression of CRFR1 in SD proximal colons, an effect that was blunted in WKYs.
Positive_regulation (induced) of Gene_expression (expression) of CRFR1 in colons
4) Confidence 0.32 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19807869 Disease Relevance 0.56 Pain Relevance 0.06
In contrast, distal CRFR1 and CRFR2 levels were higher in MS rats but were significantly reduced post OF stress.
Positive_regulation (higher) of Gene_expression (levels) of CRFR1 associated with stress
5) Confidence 0.31 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07
The stress-induced expression of CRF type 1 receptor mRNA was similar in both strains.
Positive_regulation (induced) of Gene_expression (expression) of CRF type 1 receptor mRNA associated with stress and sprains and strains
6) Confidence 0.21 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9523573 Disease Relevance 0.50 Pain Relevance 0.29
Intracerebroventricular injection of CRF type 1 and type 2 receptor antagonists prevented the effects of obestatin on gastroduodenal motility.
Positive_regulation (injection) of Gene_expression (injection) of CRF type 1 associated with antagonist and intracerebroventricular
7) Confidence 0.18 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18325980 Disease Relevance 0 Pain Relevance 0.19

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