INT74360

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 2
Total Number 20
Disease Relevance 3.85
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrb3) plasma membrane (Gabrb3)
Anatomy Link Frequency
brain 1
developmental stage 1
germline 1
palate 1
Gabrb3 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 99.48 Very High Very High Very High
cerebral cortex 114 95.96 Very High Very High Very High
gABA 3 95.88 Very High Very High Very High
Hippocampus 133 92.12 High High
Electroencephalography 266 88.08 High High
Eae 57 66.64 Quite High
GABA receptor 19 53.64 Quite High
Neurobehavioral 19 49.92 Quite Low
long-term potentiation 19 36.40 Quite Low
Pain 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleft Palate 133 99.70 Very High Very High Very High
Uniparental Disomy 152 98.44 Very High Very High Very High
Death 19 94.20 High High
Convulsion 228 90.48 High High
Angelman Syndrome 1045 88.88 High High
Targeted Disruption 76 86.24 High High
Syndrome 57 81.08 Quite High
Sprains And Strains 38 79.60 Quite High
Anxiety Disorder 380 78.72 Quite High
Embryonic Lethality 57 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of Gabrb3 and Ube3a was examined by quantitative immunoblot analysis while the expression of Atp10a was performed by regular and real-time RT-PCR analysis because a specific antibody against Atp10a was not available.
Spec (examined) Gene_expression (expression) of Gabrb3
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0.06
Mice with a Gabrb3 single mutation and Ube3a and Gabrb3 double mutations produced from this experiment have not been fully characterized.
Gene_expression (produced) of Gabrb3
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0
Similarly, there were reports suggesting paternal, maternal, and biallelic expression of GABRB3 in humans and mice using different experimental designs [14], [15], [16].
Gene_expression (expression) of GABRB3
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.30 Pain Relevance 0.07
Expression analysis of the maternal and paternal deletion mice confirmed that the Ube3a gene is maternally expressed in brain, and showed that the Atp10a and Gabrb3 genes are biallelically expressed in all brain sub-regions studied.
Gene_expression (expressed) of Gabrb3 in brain
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2924885 Disease Relevance 0.82 Pain Relevance 0.10
We examined the parental origin of expression for Ube3a, Gabrb3, and Atp10a in mice inheriting a paternal or maternal deletion by RNA or protein analysis.
Gene_expression (expression) of Gabrb3
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0
The expression of Gabrb3 was also readily detectable in m?
Gene_expression (expression) of Gabrb3
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.10 Pain Relevance 0.15
Because of a report of gender differences in monoallelic expression of Gabrb3 in mice and ATP10A in humans [10], [17], we performed the expression analysis in both sexes of mice with a deletion from Ube3a to Gabrb3.
Gene_expression (expression) of Gabrb3
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0.11
Targeting constructs for Ube3a and Gabrb3 genes
Gene_expression (genes) of Gabrb3
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.29 Pain Relevance 0
Because it was reported previously that a homozygous null mutation of Gabrb3 caused cleft palate [30], we also generated mice with single homozygous Gabrb3 mutation for the purpose of comparison.
Gene_expression (generated) of Gabrb3 in palate associated with cleft palate
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.79 Pain Relevance 0
Using mice carrying a paternal or maternal deletion of Atp10a and Gabrb3, we were able to examine the parental origin of expression for Atp10a and Gabrb3 directly.
Spec (examine) Gene_expression (expression) of Gabrb3
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.09 Pain Relevance 0.15
Similarly, our analysis did not reveal any evidence for a parental origin of expression for Gabrb3 but again the possibility of cell type or developmental stage specific expression cannot be completely ruled out.


Gene_expression (expression) of Gabrb3 in developmental stage
11) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.23 Pain Relevance 0.03
The level of Gabrb3 in m+/p?
Gene_expression (level) of Gabrb3
12) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.08 Pain Relevance 0.16
The genetic background of the region at the Gabrb3 anchor is C57BL/6J because the targeting construct for Gabrb3 was produced using a C57BL/6J genomic library.
Gene_expression (anchor) of Gabrb3
13) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.20 Pain Relevance 0.06
The Gabrb3 and Ube3a double targeted mutations without a deletion between them were also obtained in germline (data not shown).
Gene_expression (obtained) of Gabrb3 in germline
14) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.14 Pain Relevance 0
The genetic background of the region at the Gabrb3 anchor is C57BL/6J because the targeting construct for Gabrb3 was produced using a C57BL/6J genomic library.
Gene_expression (produced) of Gabrb3
15) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.14 Pain Relevance 0.06
Expression analysis of Ube3a, Atp10a, and Gabrb3 in mice with a deletion from Ube3a to Gabrb3
Gene_expression (Expression) of Gabrb3
16) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0 Pain Relevance 0
We have shown that there was no detectable expression of Ube3a, Atp10A, and Gabrb3 in homozygous deletion mice by RT-PCR or immunoblot analysis, which indicated that the deletion resulted in null alleles for all three genes.
Neg (no) Gene_expression (expression) of Gabrb3
17) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.31 Pain Relevance 0.10
No evidence for allele-specific expression of the Atp10a and Gabrb3 genes in mice
Gene_expression (expression) of Gabrb3
18) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.27 Pain Relevance 0.07
The level of Gabrb3 was 61.6±2.3% of wild-type in the m?
Gene_expression (level) of Gabrb3
19) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924885 Disease Relevance 0.09 Pain Relevance 0.13
Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor.
Neg (lack) Gene_expression (lack) of beta3 associated with anesthesia
20) Confidence 0.48 Published 1998 Journal Anesthesiology Section Title Doc Link 9523823 Disease Relevance 0 Pain Relevance 0.23

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