INT74365

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 11.03
Pain Relevance 4.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
brain 4
heart 2
plasma 1
MELC 1
aorta 1
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 164 100.00 Very High Very High Very High
Central nervous system 101 99.32 Very High Very High Very High
Hippocampus 99 98.92 Very High Very High Very High
ischemia 23 98.76 Very High Very High Very High
Analgesic 6 98.52 Very High Very High Very High
depression 22 95.72 Very High Very High Very High
cINOD 25 95.20 Very High Very High Very High
IPN 1 92.84 High High
antagonist 15 92.48 High High
Inflammatory response 5 91.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 170 100.00 Very High Very High Very High
Aging 397 99.98 Very High Very High Very High
Pruritus 101 99.92 Very High Very High Very High
Disease 158 99.48 Very High Very High Very High
Urological Neuroanatomy 51 98.92 Very High Very High Very High
Brain Hemorrhage 10 98.76 Very High Very High Very High
Chronic Renal Failure 30 98.64 Very High Very High Very High
Targeted Disruption 12 98.40 Very High Very High Very High
Cv Unclassified Under Development 13 97.96 Very High Very High Very High
Pancreatic Cancer 8 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of 5-LO and 12-LO induces their translocation to membrane compartments which was also reflected by MELC results.
Positive_regulation (Activation) of 5-LO in MELC
1) Confidence 0.47 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19697962 Disease Relevance 0.26 Pain Relevance 0.29
This study shows up-regulation of 5-lipoxygenase (5-LOX) in all grades of human PanINs and early lesions of pancreatic cancer in two different animal models (EL-Kras mice and N-nitrosobis(2-oxopropyl)amine-treated hamsters) by immunohistochemistry.
Positive_regulation (up-regulation) of lipoxygenase associated with pancreatic cancer
2) Confidence 0.43 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16024599 Disease Relevance 0.43 Pain Relevance 0.08
This study shows up-regulation of 5-lipoxygenase (5-LOX) in all grades of human PanINs and early lesions of pancreatic cancer in two different animal models (EL-Kras mice and N-nitrosobis(2-oxopropyl)amine-treated hamsters) by immunohistochemistry.
Positive_regulation (up-regulation) of 5-LOX associated with pancreatic cancer
3) Confidence 0.43 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16024599 Disease Relevance 0.43 Pain Relevance 0.08
Aging generally increased 5-LOX DNA methylation but this effect was differential with respect to the DNA region studied, the type of the tissue/organ (e.g., heart versus brain), and the brain region we investigated.
Positive_regulation (increased) of 5-LOX in brain associated with aging
4) Confidence 0.41 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.61 Pain Relevance 0.08
In conclusion, we found that in addition to altering 5-LOX mRNA content in heart and brain tissues, aging increased 5-LOX DNA methylation, and also that this effect was DNA-site- and tissue-specific.
Positive_regulation (increased) of 5-LOX in brain associated with aging
5) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.43 Pain Relevance 0.23
In the human brain, 5-LOX protein content is elevated in Alzheimer's disease [7, 20] and in response to ischemia [21].
Positive_regulation (elevated) of 5-LOX in brain associated with ischemia and disease
6) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.91 Pain Relevance 0.45
In this study with mice, we found an aging-associated 5-LOX increase in the cerebellum and the frontal cortex but not in the hippocampus.
Positive_regulation (increase) of 5-LOX in hippocampus associated with aging, urological neuroanatomy and hippocampus
7) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.72 Pain Relevance 0.20
It is believed that a nonleukocyte synthesis of leukotrienes does not require 5-LOX and that in the CNS and in the heart, leukotrienes can be produced via a transcellular biosynthetic pathway [12, 13].
Neg (not) Positive_regulation (require) of 5-LOX in heart associated with central nervous system
8) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.74 Pain Relevance 0.39
We also confirmed that aging increases 5-LOX mRNA content in the brain.
Positive_regulation (increases) of 5-LOX in brain associated with aging
9) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.75 Pain Relevance 0.18
Aging also increased 5-LOX DNA methylation and this effect was site- (i.e., enzyme) and tissue-specific.
Positive_regulation (increased) of 5-LOX associated with aging
10) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Abstract Doc Link PMC2801004 Disease Relevance 0.43 Pain Relevance 0
In our previous work with rat brain tissue, we found an aging-associated 5-LOX increase in the cerebellum and the hippocampus [37].
Positive_regulation (increase) of 5-LOX in cerebellum associated with aging and hippocampus
11) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.71 Pain Relevance 0.19
On the other hand, 5-LOX protein content in the aorta was significantly increased in old (24 months) compared to adult (6 months) rats [38].
Positive_regulation (increased) of 5-LOX in aorta
12) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.61 Pain Relevance 0.06
The deacylated compound 10 was found to be the most active of the series, inhibiting inflammation due to Baker's yeast, the mechanism of which involves mainly the activation of lipoxygenase and/or complement systems, a property which is absent from most selective cyclooxygenase only inhibiting non-steroidal anti-inflammatory drugs (NSAIDs).
Positive_regulation (activation) of lipoxygenase associated with inflammation and cinod
13) Confidence 0.26 Published 1998 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 9525091 Disease Relevance 0.61 Pain Relevance 0.45
Interestingly, this lipoxygenase product was also increased in mice receiving sEH-inhibitor treatment and this effect was additive leading to more than 4-fold higher plasma levels in 5/6-Nx under sEH inhibitor treatment as compared to control animals not receiving treatment.
Positive_regulation (increased) of lipoxygenase product in plasma
14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.17 Pain Relevance 0.04
A new series of tetrasubstituted thiophene analogues (4a-4f, 5a-5f and 8a-8i) were designed incorporating the pharmacophoric features of COX-1 (as in fenamates), 5-LOX and the p38 MAP kinase inhibitors.
Positive_regulation (features) of 5-LOX
15) Confidence 0.19 Published 2008 Journal J Enzyme Inhib Med Chem Section Abstract Doc Link 18608741 Disease Relevance 0.13 Pain Relevance 0.06
Recently, we reported the dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) activity by some phenylsulphonyl urenyl chalcone derivatives. 2,4-dichloro-4'N[N'(4methylphenylsulphonyl)urenyl] chalcone (Me-UCH9), was selected in the present study to determine its potential anti-inflammatory and analgesic effect after oral administration in several animal models related to the activation of COX-2 and 5-LO pathways.
Positive_regulation (activation) of 5-LO associated with inflammation and analgesic
16) Confidence 0.16 Published 2007 Journal Life Sci. Section Abstract Doc Link 17490689 Disease Relevance 0.63 Pain Relevance 0.34
In conclusion, we found that in addition to altering 5-LOX mRNA content in heart and brain tissues, aging increased 5-LOX DNA methylation, and also that this effect was DNA-site- and tissue-specific.
Positive_regulation (increased) of 5-LOX in heart associated with aging
17) Confidence 0.13 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.43 Pain Relevance 0.23
Inhibition of the CYP450 pathway in 5/6-Nx results in accumulation of lipoxygenase products
Positive_regulation (accumulation) of lipoxygenase
18) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.27 Pain Relevance 0.08
As a possible mechanism we suggest the accumulation of inflammatory lipoxygenase products.
Positive_regulation (accumulation) of lipoxygenase associated with inflammation
19) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.53 Pain Relevance 0.08
A recent lipidomic study showed that cytosolic phospholipase A2 (cPLA2; GIVA PLA2), a phospholipase that releases AA from phospholipids, is activated in AD and AD model mice, resulting in elevations of all of AA's different COX and lipoxygenase (LOX) metabolites.
Positive_regulation (elevations) of lipoxygenase associated with disease
20) Confidence 0.03 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.97 Pain Relevance 0.34

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