INT7437

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Context Info
Confidence 0.65
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 4.93
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFP) extracellular region (CFP)
Anatomy Link Frequency
insular cortex 3
tail 1
brain 1
arterioles 1
crown 1
CFP (Homo sapiens)
Pain Link Frequency Relevance Heat
Antinociceptive 2 99.98 Very High Very High Very High
Neuropeptide 1 99.44 Very High Very High Very High
Spontaneous pain 1 99.40 Very High Very High Very High
imagery 109 99.16 Very High Very High Very High
Thalamus 19 97.92 Very High Very High Very High
antinociception 7 97.72 Very High Very High Very High
Enkephalin 11 97.08 Very High Very High Very High
Lasting pain 60 96.08 Very High Very High Very High
Opioid 9 95.16 Very High Very High Very High
Pain 164 94.60 High High
Disease Link Frequency Relevance Heat
Poisoning 126 100.00 Very High Very High Very High
Pain 214 99.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 295 98.72 Very High Very High Very High
Congenital Anomalies 12 96.36 Very High Very High Very High
Syndrome 16 95.36 Very High Very High Very High
Hematuria 3 95.00 High High
Anxiety Disorder 156 92.72 High High
Cognitive Disorder 87 91.92 High High
Nociception 7 89.04 High High
Pressure And Volume Under Development 3 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study compared the central antinociceptive effect of an inhibitor of endopeptidase 24.15, N-[1-(R-S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB) with one of endopeptidase 24.11 N-[1-(RS)-carboxy-3-phenylpropyl]-Phe-p-aminobenzoate (cFP-F-pAB) upon central opioid antinociception induced by MERGL, metenkephalin and dynorphin A1-8. cFP-AAF-pAB, but not cFP-F-pAB increased MERGL antinociception on the tail-flick and jump tests.
Gene_expression (effect) of cFP in tail associated with antinociception, dynorphin, tail-flick, opioid and antinociceptive
1) Confidence 0.65 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1349191 Disease Relevance 0.06 Pain Relevance 1.53
The deposition of both properdin and the C5b-9 complex, as well as the usual C3, in arterioles argues for complement activation.
Gene_expression (deposition) of properdin in arterioles
2) Confidence 0.65 Published 1994 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 7944884 Disease Relevance 0.61 Pain Relevance 0.25
Crucially, when vmPFC and insular cortex groups were compared directly, there was a significant group × ratio interaction effect [F (3,93) = 4.23, P = 0.032 Greenhouse–Geisser corrected ?
Gene_expression (groups) of vmPFC in insular cortex
3) Confidence 0.56 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
The increase in betting behaviour was not restricted to the vmPFC group.
Gene_expression (group) of vmPFC
4) Confidence 0.56 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0.09 Pain Relevance 0
Fig. 4The effect of ratio on betting behaviour in the four groups of participants: healthy controls, vmPFC lesions, insular cortex lesions and the lesion control group.
Gene_expression (lesions) of vmPFC in insular cortex
5) Confidence 0.56 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
Our data demonstrate that damage to the ventromedial region is sufficient to disrupt decision-making under risk, which is consistent with both the clinical phenomenology of vmPFC lesions, as well as earlier imaging studies that had detected vmPFC signal change during risk processing with known outcome probabilities (Rogers et al., 1999a, 2004; Ernst et al., 2004).
Gene_expression (lesions) of vmPFC associated with imagery
6) Confidence 0.56 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0.05
Thus, whilst elevated betting was apparent in both the vmPFC and insular cortex lesion groups, the significant group × ratio interaction term in the omnibus ANOVA can be explained by reduced risk adjustment in the patients with insular cortex lesions but not vmPFC lesions.
Gene_expression (apparent) of vmPFC in insular cortex
7) Confidence 0.56 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
Based upon available evidence and anecdotal experience, the authors recommend the following “best practice” guidelines for CFP clinicians:



Gene_expression (clinicians) of CFP associated with poisoning
8) Confidence 0.55 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2579736 Disease Relevance 0.33 Pain Relevance 0.03
It appears that the neuropeptide is capable of blocking the production and/or secretion of antigen-specific T cell helper factor as well as of anti-OA antibodies by PFC.
Gene_expression (production) of PFC in T cell associated with neuropeptide
9) Confidence 0.50 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2415618 Disease Relevance 0 Pain Relevance 0.12
Activity in the mPFC node of the DMN has been closely associated with self-reflection (e.g. [22,24,27,32]) and recent evidence suggests that the mPFC exerts the principal causality within the network [33].
Gene_expression (node) of mPFC in node
10) Confidence 0.42 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.32 Pain Relevance 0
One recent study [93] has shown that chronic spontaneous pain is associated with increased activation of the mPFC, a region involved in detection of unfavorable outcomes and processing negative emotions and response conflict [98].
Gene_expression (activation) of mPFC associated with pain and spontaneous pain
11) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 1.14 Pain Relevance 1.24
The alpha-2A and alpha-2C subtypes are widely distributed in the brain, including the PFC, the alpha-2B receptor is most concentrated in the thalamus.
Gene_expression (distributed) of PFC in brain associated with thalamus
12) Confidence 0.19 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.15 Pain Relevance 0.29
The present developmental hypothesis suggests early deficits in PFC connectivity, in both young children and in ADHD.
Gene_expression (connectivity) of PFC associated with attention deficit hyperactivity disorder
13) Confidence 0.19 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.50 Pain Relevance 0.16
The same was found in cells cotransfected with CFP-TRPV4 and TRPV4-YFP (Fig. 5B) suggesting that interactions can occur between subunits in the homotetrameric channel.
Gene_expression (cotransfected) of CFP
14) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
N1-YFP was coexpressed with N1-CFP or CFP alone in HEK293 cells and the donor fluorescence measured during selective YFP photobleaching.
Gene_expression (coexpressed) of CFP
15) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
N1-YFP was coexpressed with N1-CFP or CFP alone in HEK293 cells and the donor fluorescence measured during selective YFP photobleaching.
Gene_expression (coexpressed) of CFP
16) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
The same was found when CFP- and YFP- fusion protein of the full-length N and C-termini, respectively, (N1, C1, Fig. 1A) were tested for interaction in fluorescence resonance energy transfer (FRET) experiments after coexpression in HEK293 cells (Fig. 4).
Gene_expression (tested) of CFP
17) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
Disruption in the PFC and its projections to other brain structures can cause distractibility, inattention, impairment in memory, and impulsivity, the core symptoms of ADHD.82
Gene_expression (Disruption) of PFC in PFC associated with attention deficit hyperactivity disorder
18) Confidence 0.10 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 0.86 Pain Relevance 0.08
Group A: made of intact, sound incisor teeth (control group), Group B: made from glass fiber post (everStick, StickTeck) and particulate filler composite resin (PFC) (Filtek Z250, 3M-ESPE) as core and complete crown, Group C: made from FC post-core complex and PFC complete crown.
Gene_expression (made) of PFC in crown
19) Confidence 0.10 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2681170 Disease Relevance 0 Pain Relevance 0
First, we propose that beliefs, i.e., propositional statements that refer to the state of the individual, which are processed in the mPFC and TPJ, contribute significantly to the evaluation of the anticipatory interoceptive signals.
Gene_expression (processed) of mPFC
20) Confidence 0.06 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886901 Disease Relevance 0.72 Pain Relevance 0.09

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