INT74374

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.28
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
nucleus 4
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 82 100.00 Very High Very High Very High
opioid receptor 15 100.00 Very High Very High Very High
agonist 16 99.20 Very High Very High Very High
Cannabinoid receptor 6 93.44 High High
tetrodotoxin 2 92.24 High High
depression 7 85.04 High High
Calcium channel 2 83.20 Quite High
Cannabinoid 5 81.60 Quite High
cocaine 4 76.64 Quite High
Nucleus accumbens 2 69.84 Quite High
Disease Link Frequency Relevance Heat
Poisoning 18 91.84 High High
Apoptosis 116 91.24 High High
Depression 7 85.04 High High
Drug Induced Neurotoxicity 12 83.52 Quite High
Amyloid Plaque 6 68.56 Quite High
Injury 12 67.52 Quite High
Targeted Disruption 7 62.52 Quite High
Disease 61 59.76 Quite High
Alzheimer's Dementia 5 58.08 Quite High
Death 26 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of protein kinase C (PKC) inhibitors and activator, as well as the systematic mutation of potential PKC phosphorylation sites in NAC1, demonstrated that phosphorylation of residue S245 by PKC is a necessary event inducing diffuse NAC1 expression outside of the nucleus.
Negative_regulation (event) of Phosphorylation (phosphorylation) of PKC in nucleus associated with kinase c
1) Confidence 0.41 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16045493 Disease Relevance 0 Pain Relevance 0.38
The use of protein kinase C (PKC) inhibitors and activator, as well as the systematic mutation of potential PKC phosphorylation sites in NAC1, demonstrated that phosphorylation of residue S245 by PKC is a necessary event inducing diffuse NAC1 expression outside of the nucleus.
Negative_regulation (event) of Phosphorylation (phosphorylation) of PKC in nucleus associated with kinase c
2) Confidence 0.41 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16045493 Disease Relevance 0 Pain Relevance 0.40
We have found that phosphorylation of a G-protein-coupled receptor by protein kinase C (PKC) disrupts modulation of ion channels by the receptor.
Negative_regulation (disrupts) of Phosphorylation (phosphorylation) of PKC associated with kinase c
3) Confidence 0.38 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9526000 Disease Relevance 0.09 Pain Relevance 0.62
We observed that rottlerin reduced As-induced phosphorylation of PKC?
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of PKC
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.26 Pain Relevance 0
At the same time, these inhibitors prevented the motility-associated increase in phosphorylation of several PKC substrates.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of PKC
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
However, treatment with taurine markedly suppressed this As-induced phosphorylation of PKC?.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of PKC associated with kinase c
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.40 Pain Relevance 0.67
by PKC, leads to two main consequences: reduced phosphorylation of tau protein and reduced degradation and subsequent accumulation of cytoplasmic ?
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of PKC associated with kinase c
7) Confidence 0.08 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.53 Pain Relevance 0.30
Agonist-dependent, GRK-mediated receptor phosphorylation and agonist-independent, PKC-mediated DOR phosphorylation were additive, but agonist-induced receptor phosphorylation could inhibit PKC-catalyzed heterologous DOR phosphorylation and subsequent internalization.
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of PKC associated with kinase c, agonist and opioid receptor
8) Confidence 0.05 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11085981 Disease Relevance 0 Pain Relevance 1.20

General Comments

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