INT74375

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 14.25
Pain Relevance 13.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
colon 6
boutons 4
paw 4
medial 3
RBL-2H3 2
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 311 100.00 Very High Very High Very High
Ventral tegmentum 205 100.00 Very High Very High Very High
depression 179 100.00 Very High Very High Very High
antagonist 155 100.00 Very High Very High Very High
Cannabinoid receptor 128 100.00 Very High Very High Very High
Inflammation 134 99.84 Very High Very High Very High
Glutamate receptor 6 99.72 Very High Very High Very High
agonist 226 99.64 Very High Very High Very High
intrathecal 27 99.56 Very High Very High Very High
fluoxetine 10 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 179 100.00 Very High Very High Very High
Li-fraumeni Syndrome 32 100.00 Very High Very High Very High
INFLAMMATION 139 99.84 Very High Very High Very High
Stress 411 99.76 Very High Very High Very High
Obesity 10 99.16 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

210 99.12 Very High Very High Very High
Anxiety Disorder 73 98.92 Very High Very High Very High
Hypersensitivity 118 98.16 Very High Very High Very High
Food Poisoning 7 97.88 Very High Very High Very High
Urological Neuroanatomy 63 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the mechanisms underlying increased CB1R expression observed in association with peripheral inflammation is incompletely understood.
Positive_regulation (increased) of Gene_expression (expression) of CB1R associated with inflammation
1) Confidence 0.70 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.03 Pain Relevance 0.65
These results suggest that CB1 expression in primary afferent neurons is increased by inflammation and that the subsequent increase in CB1 transport to peripheral axons contributes to the increased antihyperalgesic efficacy of locally administered CB1 agonist.
Positive_regulation (increased) of Gene_expression (expression) of CB1 in afferent neurons associated with antihyperalgesic, inflammation and agonist
2) Confidence 0.62 Published 2006 Journal Pain Section Abstract Doc Link 16709443 Disease Relevance 1.12 Pain Relevance 1.05
Collection of distal colon, proximal colon, and distal small intestinal samples for CB1R expression analysis
Positive_regulation (samples) of Gene_expression (expression) of CB1R in colon
3) Confidence 0.50 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.23 Pain Relevance 0.10
Collection of distal colon, proximal colon, and distal small intestinal samples for CB1R expression analysis
Positive_regulation (for) of Gene_expression (expression) of CB1R in colon
4) Confidence 0.50 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.23 Pain Relevance 0.10
Immunostaining for CB1 receptor expression was also carried out, showing a significant decrease in the density of neural cells positive for CB1 receptor in frontal, cingulate and piriform cortex, without changes in parietal, temporal and occipital regions.
Positive_regulation (Immunostaining) of Gene_expression (expression) of CB1 receptor in parietal
5) Confidence 0.49 Published 2008 Journal Brain Res. Section Abstract Doc Link 18722357 Disease Relevance 0.53 Pain Relevance 0.58
Here we investigated whether presynaptic inhibition can be caused by activation of postsynaptic group I metabotropic glutamate receptors (mGluRs) and following presynaptic cannabinoid receptor type 1 (CB1 receptor) using mechanically dissociated rat hippocampal CA3 pyramidal neurons with adherent functional synaptic boutons.
Positive_regulation (following) of Gene_expression (presynaptic) of CB1 receptor in boutons associated with cannabinoid receptor, pyramidal cell and glutamate receptor
6) Confidence 0.48 Published 2010 Journal Neuroscience Section Abstract Doc Link 19961906 Disease Relevance 0 Pain Relevance 0.80
Here we investigated whether presynaptic inhibition can be caused by activation of postsynaptic group I metabotropic glutamate receptors (mGluRs) and following presynaptic cannabinoid receptor type 1 (CB1 receptor) using mechanically dissociated rat hippocampal CA3 pyramidal neurons with adherent functional synaptic boutons.
Positive_regulation (following) of Gene_expression (presynaptic) of cannabinoid receptor type 1 in boutons associated with cannabinoid receptor, pyramidal cell and glutamate receptor
7) Confidence 0.48 Published 2010 Journal Neuroscience Section Abstract Doc Link 19961906 Disease Relevance 0 Pain Relevance 0.80
In AtT-20 cells transfected with rat cannabinoid receptor (CB1), the activation of an inwardly rectifying potassium current (Kir current) and depression of P/Q-type calcium channels by cannabinoids were prevented by stimulation of protein kinase C by 100 nM phorbol 12-myristate 13-acetate (PMA).
Positive_regulation (transfected) of Gene_expression (transfected) of CB1 in AtT-20 associated with kinase c, depression, cannabinoid receptor, cannabinoid and calcium channel
8) Confidence 0.48 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9526000 Disease Relevance 0.10 Pain Relevance 0.70
In contrast, co-administration of the CB1 antagonist SR 141716A did not attenuate this effect.
Positive_regulation (co-administration) of Gene_expression (co-administration) of CB1 associated with antagonist
9) Confidence 0.48 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16267120 Disease Relevance 0.50 Pain Relevance 0.56
The early alterations in abdominal contractile response to colorectal distension of agonist/antagonist treated rats and the increased levels of CB1R mRNA in myenteric plexuses of enhanced sensation colons seem to point to an important, if not predominant, function of the endogenous cannabinoid system at peripheral sites.
Positive_regulation (increased) of Gene_expression (levels) of CB1R mRNA in colons associated with cannabinoid, antagonist and agonist
10) Confidence 0.47 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.70 Pain Relevance 0.82
Stress-induced up-regulation of CB1R expression in the large and small intestine
Positive_regulation (regulation) of Gene_expression (expression) of CB1R in small intestine associated with stress
11) Confidence 0.47 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.09 Pain Relevance 0.41
We found significant increased expression for CB1R mRNA in samples from chronically partial restraint stressed animals compared with control (semiquantitative analysis, 0.79 ± 0.13, 0.66 ± 0.10 and 0.88 ± 0.10 in sham PR; 1.46 ± 0.21, 1.40 ± 0.14 and 1.44 ± 0.17 in PR; p = 0.019, 0.001 and 0.013, respectively; Fig. 2 and 3).

2) CB1R protein expression in intestine

Positive_regulation (increased) of Gene_expression (expression) of CB1R mRNA in intestine associated with stress
12) Confidence 0.47 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.02 Pain Relevance 0.10
PR Stress significantly enhanced CB1R expression
Positive_regulation (enhanced) of Gene_expression (expression) of CB1R associated with stress
13) Confidence 0.47 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.89 Pain Relevance 0.17
Higher levels of CB1 receptor expression in frontal, cingulated and piriform cortex, without differences in temporal, parietal and occipital cortex, were observed in obese Zucker rats, with respect to their lean littermates.
Positive_regulation (levels) of Gene_expression (expression) of CB1 receptor in piriform cortex associated with obesity
14) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18722357 Disease Relevance 0.57 Pain Relevance 0.37
However, we found a significant increase in levels of CB1 receptor-mRNA transcripts, measured by in situ hybridization, in the lesioned side in both the lateral and medial caudate-putamen.
Positive_regulation (increase) of Gene_expression (levels) of CB1 in medial
15) Confidence 0.44 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.15
In order to examine expression of Iba-1 (a microglial marker), GFAP (an astrocytic marker), ED2/CD163 (a perivascular cell marker) and CB1/CB2 receptor and CB1/CB2 receptor co-localization with other cell markers in response to paw incision, untreated animals received paw incision surgery and were perfused as described below on days 1, 3 and 9 after surgery (n?
Spec (examine) Positive_regulation (examine) of Spec (examine) Gene_expression (expression) of CB1 in paw
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.07 Pain Relevance 0.16
We then administered concomitant CB1 and CB2 receptor antagonists/inverse agonists (AM281 and AM630, 1 mg.kg?
Positive_regulation (concomitant) of Gene_expression (antagonists) of CB1 associated with antagonist and agonist
17) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2878341 Disease Relevance 0.84 Pain Relevance 1.17
3), mixed CB1 and CB2 receptor antagonists followed by propentofylline on days 14 and 15 (n?
Positive_regulation (mixed) of Gene_expression (mixed) of CB1 associated with antagonist
18) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.30
In order to examine expression of Iba-1 (a microglial marker), GFAP (an astrocytic marker), ED2/CD163 (a perivascular cell marker) and CB1/CB2 receptor and CB1/CB2 receptor co-localization with other cell markers in response to paw incision, untreated animals received paw incision surgery and were perfused as described below on days 1, 3 and 9 after surgery (n?
Spec (examine) Positive_regulation (examine) of Spec (examine) Gene_expression (expression) of CB1 in paw
19) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.07 Pain Relevance 0.16
In conclusion, the results suggest that an acute dose of ethanol induces neuroplastic alterations in proenkephalin, tyrosine hydroxylase and cannabinoid CB1 receptor gene expressions that may contribute to trigger the rewarding effects of ethanol consumption.
Positive_regulation (induces) of Gene_expression (expressions) of cannabinoid CB1 receptor gene associated with cannabinoid
20) Confidence 0.40 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17964122 Disease Relevance 0.08 Pain Relevance 0.46

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