INT74376

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 2
Speculated 9
Reported most in Abstract
Documents 173
Total Number 186
Disease Relevance 73.43
Pain Relevance 89.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
neurons 12
spinal 9
paw 7
bladder 6
brain 4
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 2137 100.00 Very High Very High Very High
agonist 1610 100.00 Very High Very High Very High
antagonist 1034 100.00 Very High Very High Very High
Cannabinoid receptor 964 100.00 Very High Very High Very High
Ventral tegmentum 528 100.00 Very High Very High Very High
Opioid 199 100.00 Very High Very High Very High
nociceptor 78 100.00 Very High Very High Very High
Substantia nigra 24 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
Periaqueductal grey 51 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 8 100.00 Very High Very High Very High
Urological Neuroanatomy 473 99.98 Very High Very High Very High
Overactive Bladder 426 99.98 Very High Very High Very High
Nociception 545 99.84 Very High Very High Very High
Nervous System Injury 84 99.84 Very High Very High Very High
Stress 1240 99.68 Very High Very High Very High
Low Back Pain 1 99.68 Very High Very High Very High
Targeted Disruption 119 99.66 Very High Very High Very High
Pain 959 99.64 Very High Very High Very High
Ganglion Cysts 65 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunocytochemistry, we show that in addition to its neuronal localization, CB1 is also expressed in numerous astrocytes in laminae I and II of the rat dorsal horn.
Gene_expression (expressed) of CB1 in dorsal horn associated with dorsal horn
1) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12161251 Disease Relevance 0.09 Pain Relevance 0.61
This treatment resulted in a decrease in lumbar spinal CB1 receptor expression accompanied by a decrease in the response thresholds to both innocuous tactile and noxious thermal stimuli.
Gene_expression (expression) of CB1 receptor in spinal associated with cannabinoid receptor
2) Confidence 0.78 Published 2002 Journal Pain Section Abstract Doc Link 12435473 Disease Relevance 0.32 Pain Relevance 0.81
Stress-induced up-regulation of CB1R expression in the large and small intestine
Gene_expression (expression) of CB1R in small intestine associated with stress
3) Confidence 0.78 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.09 Pain Relevance 0.41
However, the mechanisms underlying increased CB1R expression observed in association with peripheral inflammation is incompletely understood.
Gene_expression (expression) of CB1R associated with inflammation
4) Confidence 0.78 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.97 Pain Relevance 0.65
Recent data indicate a protective function of up-regulated endocannabinoid levels in colitis.38,27 In rats and guinea pigs, besides an expression in cholinergic myenteric neurons, a close association between CB1R immunoreactivity and fibers labeled for a synaptic protein has been described, suggesting a role in the modulation of transmitter release.39 Similarly, expression of CB1Rs has been found to be up-regulated in rats during an experimental intestinal inflammation.26,40
Gene_expression (expression) of CB1Rs in neurons associated with colitis, endocannabinoid and inflammation
5) Confidence 0.78 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 1.19 Pain Relevance 0.46
Collection of distal colon, proximal colon, and distal small intestinal samples for CB1R expression analysis
Gene_expression (expression) of CB1R in colon
6) Confidence 0.78 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.23 Pain Relevance 0.10
Thus, present study show the evidence that neurons that express low levels of CB1Rs in basal conditions start to express this receptor to enhance endocannabinoid signaling.
Gene_expression (express) of CB1Rs in neurons associated with endocannabinoid
7) Confidence 0.78 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.95 Pain Relevance 0.63
Immunofluorescence and western blot analysis were used to assess the expression of CB1 and TRPV1 receptors in dorsal root ganglion (DRG) neurons.
Gene_expression (expression) of CB1 in DRG
8) Confidence 0.77 Published 2009 Journal Gut Section Body Doc Link 18936104 Disease Relevance 0.18 Pain Relevance 0
Expression of cannabinoid 1 (CB1) and vanilloid 1 (VR1) receptor proteins was studied in adult, cultured rat dorsal root ganglion neurons.
Gene_expression (Expression) of CB1 in neurons associated with ganglion cysts, cannabinoid and root ganglion neuron
9) Confidence 0.77 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036202 Disease Relevance 0.32 Pain Relevance 0.21
Our data suggests that nociceptive primary sensory neurons co-express CB1 and VR1 receptors to a very high degree.
Gene_expression (co-express) of CB1 in primary sensory neurons associated with nociception
10) Confidence 0.77 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036202 Disease Relevance 0.46 Pain Relevance 0.17
Expression of cannabinoid 1 (CB1) and vanilloid 1 (VR1) receptor proteins was studied in adult, cultured rat dorsal root ganglion neurons.
Gene_expression (Expression) of cannabinoid 1 in neurons associated with ganglion cysts, cannabinoid and root ganglion neuron
11) Confidence 0.77 Published 2000 Journal Neuroscience Section Abstract Doc Link 11036202 Disease Relevance 0.32 Pain Relevance 0.21
Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons.
Gene_expression (expressed) of Cannabinoid 1 in primary sensory neurons associated with nociception and cannabinoid
12) Confidence 0.77 Published 2000 Journal Neuroscience Section Title Doc Link 11036202 Disease Relevance 0.42 Pain Relevance 0.38
Higher levels of CB1 receptor expression in frontal, cingulated and piriform cortex, without differences in temporal, parietal and occipital cortex, were observed in obese Zucker rats, with respect to their lean littermates.
Gene_expression (expression) of CB1 receptor in piriform cortex associated with obesity
13) Confidence 0.76 Published 2008 Journal Brain Res. Section Abstract Doc Link 18722357 Disease Relevance 0.57 Pain Relevance 0.37
Immunostaining for CB1 receptor expression was also carried out, showing a significant decrease in the density of neural cells positive for CB1 receptor in frontal, cingulate and piriform cortex, without changes in parietal, temporal and occipital regions.
Gene_expression (expression) of CB1 receptor in parietal
14) Confidence 0.76 Published 2008 Journal Brain Res. Section Abstract Doc Link 18722357 Disease Relevance 0.53 Pain Relevance 0.58
CB1 is expressed at high levels in many brain regions, and several endogenous brain lipids have been identified as CB1 ligands.
Gene_expression (expressed) of CB1 in brain
15) Confidence 0.74 Published 2002 Journal Science Section Abstract Doc Link 11976437 Disease Relevance 0.13 Pain Relevance 0.31
This supports a critical role for dopamine in the control of CB1 receptor gene expression.
Gene_expression (expression) of CB1 associated with dopamine
16) Confidence 0.73 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.11
Cannabinoid receptors (CB1) are densely expressed in regions that provide excitatory innervation to the NAc, such as the amygdala, the cortex and the hippocampus.
Gene_expression (expressed) of CB1 in hippocampus associated with nucleus accumbens, cannabinoid receptor, hippocampus and amygdala
17) Confidence 0.72 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12081659 Disease Relevance 0 Pain Relevance 0.99
On day 14, the expression of immunoreactive CB1 and CB2 was found in all mesometrial decidual cells and in the placenta (giant trophoblast and spongiotrophoblastic cells) (Figure 6A, C, D).
Gene_expression (expression) of CB1 in placenta
18) Confidence 0.72 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
Expression of CB1, CB2, and TRPV1 was analyzed using an avidin-biotin alkaline phosphatase complex immunohistochemical technique (Vectastain ABC kit, Vector Laboratories, CA, USA).
Spec (analyzed) Gene_expression (Expression) of CB1
19) Confidence 0.72 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry revealed that CB1 is expressed mainly in decidual cells throughout gestation suggesting that an action mediated by CB1 is not only associated with implantation [19], but also with the maintenance of pregnancy.
Gene_expression (expressed) of CB1
20) Confidence 0.72 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.08

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