INT74377

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 38
Total Number 43
Disease Relevance 16.93
Pain Relevance 24.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
spinal 2
output neurons 2
dorsal horn 2
neurons 2
brain 1
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 177 100.00 Very High Very High Very High
agonist 148 100.00 Very High Very High Very High
Pain 102 100.00 Very High Very High Very High
Cannabinoid receptor 101 100.00 Very High Very High Very High
Antinociceptive 40 99.98 Very High Very High Very High
cannabis 24 99.98 Very High Very High Very High
antagonist 113 99.96 Very High Very High Very High
Opioid 31 99.92 Very High Very High Very High
Hyperalgesia 34 99.80 Very High Very High Very High
mu opioid receptor 5 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 92 100.00 Very High Very High Very High
Nociception 64 100.00 Very High Very High Very High
Depression 19 99.88 Very High Very High Very High
Hyperalgesia 50 99.80 Very High Very High Very High
Neuropathic Pain 120 99.72 Very High Very High Very High
Cannabis Dependence 1 99.60 Very High Very High Very High
INFLAMMATION 45 99.32 Very High Very High Very High
Diabetes Mellitus 20 99.28 Very High Very High Very High
Disease 65 99.26 Very High Very High Very High
Urological Neuroanatomy 85 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutating this serine to alanine did not affect the ability of CB1 to modulate currents, but it eliminated disruption by PMA, demonstrating that PKC can disrupt ion channel modulation by receptor phosphorylation.
Neg (not) Regulation (affect) of CB1 associated with kinase c and cannabinoid receptor
1) Confidence 0.59 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9526000 Disease Relevance 0.08 Pain Relevance 0.79
Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (CB1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively.
Regulation (control) of CB1 in dorsal horn associated with pain, cannabinoid receptor, primary afferent fibers, cannabinoid and dorsal horn
2) Confidence 0.45 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12161251 Disease Relevance 0.10 Pain Relevance 0.59
Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (CB1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively.
Regulation (control) of cannabinoid receptor-1 in dorsal horn associated with pain, cannabinoid receptor, primary afferent fibers, cannabinoid and dorsal horn
3) Confidence 0.45 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12161251 Disease Relevance 0.10 Pain Relevance 0.59
The present experiments investigated the influence of CB1 receptors in the ventral striatopallidal system on opiate-induced neurochemical events and opiate self-administration behavior in rats.
Spec (investigated) Regulation (influence) of CB1 in ventral associated with opiate
4) Confidence 0.45 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16123766 Disease Relevance 0 Pain Relevance 0.80
To determine the effect of the CB1R agonist in controls, we tested the response to ACEA or vehicle injection in animals previously subjected to repeated sham PR.
Spec (determine) Regulation (effect) of CB1R associated with stress and agonist
5) Confidence 0.45 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912121 Disease Relevance 0.53 Pain Relevance 0.43
The effects of CB1 and CB2 receptor agonists and antagonists on the abdominal contractile response to colorectal distension (CRD) in basal conditions and after 2,4,6-trinitrobenzenesulphonic acid-induced colitis were investigated.
Spec (investigated) Regulation (effects) of CB1 associated with colitis, antagonist and agonist
6) Confidence 0.45 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16961698 Disease Relevance 0.90 Pain Relevance 0.52
Two bioassays were used to compare the effects of the CB1 receptor agonist CP 55,940 and morphine on dissociated adult rat DRG neurons.
Regulation (effects) of CB1 receptor in neurons associated with agonist and morphine
7) Confidence 0.44 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973253 Disease Relevance 0.07 Pain Relevance 0.69
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats.
Regulation (effects) of CB1 in neurons associated with cannabinoid, neuropathic pain, agonist and dorsal horn neuron
8) Confidence 0.44 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16045490 Disease Relevance 0.77 Pain Relevance 0.94
Effects of the CB2 receptor agonist, JWH-133, and the CB1 receptor agonist, arachidonyl-2-chloroethylamide (ACEA), on primary afferent fibres were determined by calcium imaging studies of adult dorsal root ganglion (DRG) neurons taken from neuropathic and sham-operated rats.
Regulation (Effects) of CB1 receptor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, primary afferent fibers, neuropathic pain, agonist and imagery
9) Confidence 0.44 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16045490 Disease Relevance 0.84 Pain Relevance 0.83
Several lines of evidence show that endogenous and exogenous cannabinoids modulate pain transmission at the spinal level through specific cannabinoid-1 (CB1) receptors.
Regulation (modulate) of CB1 in spinal associated with pain and cannabinoid
10) Confidence 0.44 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934482 Disease Relevance 0.17 Pain Relevance 0.37
Several lines of evidence show that endogenous and exogenous cannabinoids modulate pain transmission at the spinal level through specific cannabinoid-1 (CB1) receptors.
Regulation (modulate) of cannabinoid-1 in spinal associated with pain and cannabinoid
11) Confidence 0.44 Published 2002 Journal Neuroscience Section Abstract Doc Link 11934482 Disease Relevance 0.17 Pain Relevance 0.37
In the present study, we examined the possible alteration in the status of cannabinoid CB1 receptors in the basal ganglia of rats with unilateral lesions of those neurons caused by 6-hydroxydopamine.
Spec (possible) Regulation (alteration) of CB1 in basal ganglia associated with cannabinoid
12) Confidence 0.43 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794065 Disease Relevance 0 Pain Relevance 0.13
In fact, although this, to our knowledge, is the first report on the behavioral action of a CB1 receptor antagonist in a model of PD-associated depressive symptoms, the profile of CB1 antagonists on emotionality has been demonstrated in other rodent models of depression.
Regulation (profile) of CB1 associated with depression, antagonist and disease
13) Confidence 0.42 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2957172 Disease Relevance 0.37 Pain Relevance 0.58
Homogenates of brain and spleen were used as positive controls for CB1, TRPV1 and CB2, respectively.
Regulation (controls) of CB1 in spleen
14) Confidence 0.42 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0
The smooth muscle cells of blood vessels exhibited immunopositivity for CB1 and CB2 (data not shown).
Regulation (immunopositivity) of CB1 in smooth muscle cells
15) Confidence 0.42 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.04
The results suggest that the weaning process might produce some sexually dimorphic developmental changes in CB1 receptor function.
Regulation (changes) of CB1 receptor
16) Confidence 0.41 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15251268 Disease Relevance 0.35 Pain Relevance 0.34
Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.
Regulation (Effect) of CB1 in sciatic nerve associated with nociception, pain, demyelination, eae, antagonist, cannabinoid, injury and sciatic nerve
17) Confidence 0.41 Published 2005 Journal Pain Section Title Doc Link 15936882 Disease Relevance 1.04 Pain Relevance 1.22
Indeed, CB1 receptors are up-regulated in the thalamus of nerve-injured rats (Siegling et al., 2001) and therefore provide an additional target for the endocannabinoids.
Regulation (regulated) of CB1 in nerve associated with endocannabinoid and thalamus
18) Confidence 0.39 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.32 Pain Relevance 0.44
Up-regulation of CB1 receptors might be a compensatory mechanism but the precise elucidation of the effects of CB1 changes on disinhibition needs further studies.
Regulation (regulation) of CB1
19) Confidence 0.38 Published 2010 Journal Brain Res. Section Abstract Doc Link 20211611 Disease Relevance 1.59 Pain Relevance 1.23
This can also explain the difficulty faced by researchers engaged in investigating the role of CB1 and CB2 receptors using pharmacological antagonists and agonists.
Spec (investigating) Regulation (role) of CB1 associated with antagonist and agonist
20) Confidence 0.35 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.97 Pain Relevance 1.05

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