INT74386

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 26
Disease Relevance 3.64
Pain Relevance 6.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra2)
Anatomy Link Frequency
neurons 6
sympathetic 2
IB4 2
embryos 1
sensory neurons 1
Gfra2 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 372 100.00 Very High Very High Very High
dorsal root ganglion 6 99.96 Very High Very High Very High
Nerve growth factor 554 99.58 Very High Very High Very High
trigeminal ganglion 19 99.34 Very High Very High Very High
unmyelinated 82 99.20 Very High Very High Very High
Calcitonin gene-related peptide 426 97.64 Very High Very High Very High
TRP channel 133 95.20 Very High Very High Very High
peripheral neuropathy 3 89.04 High High
Pain 7 88.52 High High
Somatostatin 3 86.56 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1260 99.96 Very High Very High Very High
Targeted Disruption 270 98.80 Very High Very High Very High
Peripheral Neuropathy 6 89.04 High High
Pain 21 88.52 High High
Nociception 21 87.48 High High
Death 133 87.08 High High
Inflammatory Pain 4 75.00 Quite High
Nervous System Injury 3 75.00 Quite High
INFLAMMATION 38 37.08 Quite Low
Apoptosis 152 20.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that the vast majority (approximately 85%) of IB4 binding and P2X3 purinoreceptor-positive neurons, but virtually none of the calcitonin gene-related peptide (CGRP) or vanilloid receptor transient receptor potential vanilloid 1-positive neurons in mouse dorsal root ganglion (DRG) express GFRalpha2.
Gene_expression (express) of GFRalpha2 in neurons associated with ganglion cysts, dorsal root ganglion and calcitonin gene-related peptide
1) Confidence 0.42 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16481427 Disease Relevance 0.73 Pain Relevance 0.63
One of these factors, neurturin, is expressed in the epidermis, whereas its GDNF family receptor alpha2 (GFRalpha2) is expressed in the majority of unmyelinated Ret-positive sensory neurons.
Gene_expression (expressed) of GFRalpha2 in sensory neurons associated with unmyelinated
2) Confidence 0.42 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16481427 Disease Relevance 0.57 Pain Relevance 0.42
In adult rats, more than half of the ret-positive DRG cells express GFRalpha1 and one third GFRalpha2.
Gene_expression (express) of GFRalpha2
3) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.41
Moreover, in ret mutant mice, the expression of GFRalpha1 and GFRalpha2 is reduced in DRG.
Gene_expression (expression) of GFRalpha2
4) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
In addition, GFRalpha1- and GFRalpha2-expressing cells are reduced at P2 and P10 in ret mutants by 60% and 25%, respectively (Luo et al. 2007).The results suggest that NGF signalling controls the initial expression of GFRalpha1 and GFRalpha2, whereas ret autoregulates their levels at later stages.
Gene_expression (expression) of GFRalpha2 associated with nerve growth factor
5) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
GFRalpha1-expressing DRG neurons are absent in newborn NGF/Bax mutant mice and GFRalpha2 expression is strongly reduced.
Gene_expression (expression) of GFRalpha2 in neurons associated with nerve growth factor
6) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
3, b) shows strong GFRalpha2 expression in the majority of neurons in a sympathetic ganglion (open arrowhead) and a DRG (asterisk).
Gene_expression (expression) of GFRalpha2 in sympathetic ganglion associated with ganglion cysts
7) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.34 Pain Relevance 0
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Gene_expression (.Expression) of GFRalpha2 associated with nerve growth factor
8) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.16
Fig. 3Expression of mRNAs for GFRalpha2 and GFRalpha3 in sympathetic ganglia and DRG of a newborn mouse.
Gene_expression (3Expression) of GFRalpha2 in sympathetic
9) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.33 Pain Relevance 0
In P14 mice, 61% and 14% of ret-positive cells express GFRalpha2 and GFRalpha3, respectively (Luo et al. 2007).
Gene_expression (express) of GFRalpha2
10) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.41
Data on the coexpression of GFRalpha receptors differ between studies (Bennett et al. 1998; Kashiba et al. 2003).Expression of GFRalpha1 and GFRalpha2, but not GFRalpha3, depends on NGF, as shown in newborn NGF/Bax double-mutant mice where GFRalpha1 is undetectable and GFRalpha2 expression is strongly reduced (Luo et al. 2007).
Gene_expression (expression) of GFRalpha2 associated with nerve growth factor
11) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.17
The expression of mRNAs for GFRalpha1, GFRalpha2, GFRalpha3 and ret is dynamically regulated in mouse sympathetic ganglia during embryogenesis (Nishino et al. 1999; Enomoto et al. 2001).
Gene_expression (expression) of GFRalpha2 in sympathetic
12) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.46 Pain Relevance 0.04
Some 34% of ret-positive cells express GFRalpha2 and 33% express GFRalpha3 in the lumbar DRG of adult rat (Kashiba et al. 2003).
Gene_expression (express) of GFRalpha2
13) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.47
There is a large but incomplete overlap of ret and GFRalpha expression ret expression overlaps largely with expression of GFRalpha1, GFRalpha2 and GFRalpha3.
Gene_expression (expression) of GFRalpha2
14) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.58
Conversely, 79% of GFRalpha1-positive cells express ret (Kashiba et al. 2003) and more than 90% of GFRalpha2- and GFRalpha3-expressing cells are ret-positive in adult rats (Kashiba et al. 1998, 2003; Orozco et al. 2001).
Gene_expression (express) of GFRalpha2
15) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.30
For neurturin and GFRalpha2 mutants, no DRG neuron counts are available.
Gene_expression (mutants) of GFRalpha2 in neuron
16) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.15 Pain Relevance 0.22
In the trigeminal ganglion of mouse embryos, GFRalpha1 and GFRalpha2 mRNAs can be detected by ISH preceding ret expression (Luukko et al. 1997).
Gene_expression (detected) of GFRalpha2 in embryos associated with ganglion cysts and trigeminal ganglion
17) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.10 Pain Relevance 0.43
In contrast, GFRalpha1- and GFRalpha2-positive DRG neurons depend on both signalling pathways.
Gene_expression (neurons) of GFRalpha2-positive in neurons
18) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
m

GFRalpha1 mRNA as analysed by ISH is detectable at E12.5, gradually decreases thereafter and is undetectable at P5 (Nishino et al. 1999). mRNAs for GFRalpha2 and GFRalpha3 are expressed in most SCG cells at E12.5 and subsequently become restricted to smaller subpopulations.

Gene_expression (expressed) of GFRalpha2 associated with ganglion cysts
19) Confidence 0.05 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.35 Pain Relevance 0
In addition, ret mutation leads to a reduction of GFRalpha1 and GFRalpha2, but not GFRalpha3, expression.
Gene_expression (expression) of GFRalpha2
20) Confidence 0.04 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.44

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