INT74389

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1998
Last Reported 2011
Negated 2
Speculated 11
Reported most in Abstract
Documents 131
Total Number 143
Disease Relevance 58.52
Pain Relevance 57.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neurons 18
spinal cord 10
glial cells 5
sensory neurons 5
neuronal 5
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 729 100.00 Very High Very High Very High
qutenza 323 100.00 Very High Very High Very High
withdrawal 109 100.00 Very High Very High Very High
Morphine 43 100.00 Very High Very High Very High
Somatostatin 29 100.00 Very High Very High Very High
Glial derived neurotrophic factor 8 100.00 Very High Very High Very High
Calcitonin gene-related peptide 519 99.98 Very High Very High Very High
intrathecal 58 99.98 Very High Very High Very High
Dorsal horn 57 99.98 Very High Very High Very High
electroacupuncture 16 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 950 100.00 Very High Very High Very High
Opiate Addiction 2 100.00 Very High Very High Very High
Neurodegenerative Disease 57 99.92 Very High Very High Very High
Cv General 3 Under Development 13 99.84 Very High Very High Very High
Ganglion Cysts 571 99.82 Very High Very High Very High
Death 91 99.78 Very High Very High Very High
Spinal Injuries 9 99.66 Very High Very High Very High
Nervous System Injury 105 99.64 Very High Very High Very High
Tooth Injuries 6 99.62 Very High Very High Very High
Experimental Autoimmune Neuritis 18 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have shown that application of 1, 25 dihydroxyvitamin D(3) (D3) enhances GDNF mRNA expression in vitro.
Gene_expression (expression) of GDNF mRNA
1) Confidence 0.78 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10699453 Disease Relevance 0.26 Pain Relevance 0.07
We also studied the dynamic changes of GDNF expression in rats during chronic inflammation using injection of complete Freund's adjuvant as a model of chronic pain.
Gene_expression (expression) of GDNF associated with inflammation and lasting pain
2) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617957 Disease Relevance 0.97 Pain Relevance 1.02
To evaluate the involvement of GDNF in experimental autoimmune neuritis (EAN) pathogenesis, the expression of GDNF in rat sciatic nerves with EAN was studied.
Gene_expression (expression) of GDNF in sciatic nerves associated with experimental autoimmune neuritis, sciatic nerve and neuritis
3) Confidence 0.78 Published 2010 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 20626773 Disease Relevance 1.09 Pain Relevance 0.90
GDNF mRNA-positive signals were detected in neurons of the ventral horn, especially in lamina IX.
Gene_expression (detected) of GDNF mRNA-positive in neurons
4) Confidence 0.78 Published 2007 Journal Neurochem Res Section Abstract Doc Link PMC2270371 Disease Relevance 0.31 Pain Relevance 0.07
Therefore, it raised the possibility that GDNF was synthesized by cells of the spinal cord and the GDNF expression may be changed after lesion, which implies that GDNF plays a potential role in both physiological and pathological conditions.
Gene_expression (expression) of GDNF in spinal cord associated with spinal cord
5) Confidence 0.78 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.49 Pain Relevance 0.13
GDNF immunoreactivity products in neurons from the ventral horn of the rostral stump were strongly stained at 3 and 7 dpo, and in the caudal stump at 14 dpo, suggesting that the GDNF expression in neurons was up-regulated following injury.
Gene_expression (expression) of GDNF in ventral associated with injury
6) Confidence 0.78 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.40 Pain Relevance 0.03
Two-color immunohistochemical staining for simultaneous detection of glial fibrillary acidic protein (GFAP)/GDNF expression was performed as described above.
Gene_expression (expression) of GDNF
7) Confidence 0.78 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.41 Pain Relevance 0.03
Therefore, it raised the possibility that GDNF was synthesized by cells of the spinal cord and the GDNF expression may be changed after lesion, which implies that GDNF plays a potential role in both physiological and pathological conditions.
Gene_expression (synthesized) of GDNF in spinal cord associated with spinal cord
8) Confidence 0.78 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.45 Pain Relevance 0.13
For detection of GDNF cellular expression in situ, we used Digoxigenin-labeled oligonucleotide probe designed by Primer premier 5.0 package which was complementary to the rats GDNF gene sequence (33 mer, 5?
Gene_expression (expression) of GDNF
9) Confidence 0.78 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.26 Pain Relevance 0.19
These results indicated that GDNF expression in astrocytes may be involved in neuroplasticity following spinal cord transection injury.
Gene_expression (expression) of GDNF in spinal cord associated with injury and spinal cord
10) Confidence 0.78 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.67 Pain Relevance 0.20
It has been reported that GDNF produced by skeletal muscle is taken up at the nerve terminals and retrogradely transported to motoneurons of the ventral horn by axons [30].
Gene_expression (produced) of GDNF in motoneurons
11) Confidence 0.78 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.44 Pain Relevance 0.08
Such neuronal survival was related to in vivo mRNA up regulation as well as expression of BDNF and GDNF.
Gene_expression (expression) of GDNF in neuronal
12) Confidence 0.75 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19049875 Disease Relevance 0 Pain Relevance 0.04
GDNF family receptor alpha (GFRalpha) 3, the ligand binding domain of the ARTN receptor, is expressed in 34% of dorsal root ganglion (DRG) cells, predominantly in the peptidergic population of C-fibres and in a proportion of the isolectin B4 (IB4)-binding population.
Gene_expression (expressed) of GDNF in DRG associated with ganglion cysts, c fibre and dorsal root ganglion
13) Confidence 0.75 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 17117942 Disease Relevance 0.51 Pain Relevance 0.60
GDNF is expressed in the adult striatum, but its signalling tyrosine kinase receptor, c-ret, has not been detected in this structure by in situ hybridization.
Gene_expression (expressed) of GDNF in striatum
14) Confidence 0.75 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 9987028 Disease Relevance 0.10 Pain Relevance 0.03
Using immunohistochemistry, Western blot, and RT-PCR analysis techniques, the present study observed the effects of EA on the expression of GDNF and GDNF family receptor alpha-1 (GFRalpha-1, the high-affinity receptor of GDNF) in neuropathic pain rats.
Gene_expression (expression) of GDNF associated with neuropathic pain and electroacupuncture
15) Confidence 0.74 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.83 Pain Relevance 1.21
Using immunohistochemistry, Western blot, and RT-PCR analysis techniques, the present study observed the effects of EA on the expression of GDNF and GDNF family receptor alpha-1 (GFRalpha-1, the high-affinity receptor of GDNF) in neuropathic pain rats.
Gene_expression (expression) of GDNF associated with neuropathic pain and electroacupuncture
16) Confidence 0.74 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.83 Pain Relevance 1.21
The present study examined the expression of GDNF and GFRalpha-1 (the high-affinity receptor of GDNF) in dorsal root ganglions (DRG) in a rat model of neuropathic pain induced by chronic constriction injury (CCI) to the sciatic nerve.
Spec (examined) Gene_expression (expression) of GDNF in sciatic nerve associated with ganglion cysts, eae, injury, neuropathic pain and sciatic nerve
17) Confidence 0.72 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.07 Pain Relevance 0.71
OBJECTIVE: To investigate the expression of glial cell derived neurotrophic factor (GDNF) and its receptor GDNFR-alpha (GFRalpha-1) and GDNFR-beta (Ret) genes and the effects of muscarinic receptor antagonists, NMDA receptor antagonist, inhibitor of nitric oxide synthase on the expression of these genes in the spinal cord, brainstem and frontal cortex during morphine withdrawal, and to observe the effects of GDNF antisense oligoneucleotide (i.c.v) on the morphine withdrawal symptoms in rats.
Spec (investigate) Gene_expression (expression) of GDNF in spinal cord associated with medulla, nmda receptor antagonist, antagonist, urological neuroanatomy, withdrawal, morphine and spinal cord
18) Confidence 0.72 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 11798749 Disease Relevance 0.25 Pain Relevance 0.64
CONCLUSION: The results not only provide direct evidence that the expressions of GDNF and its receptors mRNA in glial cells play an important role in mediating the process of morphine dependence and may be account for the long-term neuro-adaptation associated with morphine dependence, but also suggest that muscarinic receptor, NMDA receptor and nitric oxide pathways may be involved in the expression of GDNF and GDNF receptor genes during morphine withdrawal.


Gene_expression (expressions) of GDNF in glial cells
19) Confidence 0.72 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0 Pain Relevance 0
The expressions of both GDNF and GDNFR-alpha in the frontal cortex were decreased by treatment with MK801 (0.5 mg/kg), and the expressions of GDNF in both the stem and cortex, and GDNFR-beta in the brainstem decreased by treatment with the methyl-scopolamine (0.5 mg/kg).
Gene_expression (expressions) of GDNF in brainstem
20) Confidence 0.72 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox