INT7439

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 52
Total Number 54
Disease Relevance 19.97
Pain Relevance 17.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFP) extracellular region (CFP)
Anatomy Link Frequency
PFC 10
insular cortex 5
brain 2
striatum 2
nucleus accumbens 2
CFP (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 770 100.00 Very High Very High Very High
Anterior cingulate cortex 160 100.00 Very High Very High Very High
Somatosensory cortex 108 100.00 Very High Very High Very High
insula 100 100.00 Very High Very High Very High
primary somatosensory cortex 22 100.00 Very High Very High Very High
amygdala 283 99.88 Very High Very High Very High
Acupuncture 314 99.74 Very High Very High Very High
agonist 129 99.72 Very High Very High Very High
Pain 529 99.48 Very High Very High Very High
Hippocampus 171 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 82 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 162 99.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 415 99.52 Very High Very High Very High
Pain 714 99.48 Very High Very High Very High
Cognitive Disorder 1875 99.30 Very High Very High Very High
Depression 461 98.64 Very High Very High Very High
Complex Regional Pain Syndromes 27 98.04 Very High Very High Very High
Low Back Pain 120 97.68 Very High Very High Very High
Injury 41 97.56 Very High Very High Very High
Rheumatoid Arthritis 18 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, patients may actively attend to or ignore SBN when instructed to relax and stay still; this might cause increased dmPFC activation in the patient group only.
Positive_regulation (activation) of PFC
1) Confidence 0.67 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2999982 Disease Relevance 0.53 Pain Relevance 0
Critically, the SD of the total points was increased dramatically in both the vmPFC and insular cortex simulations, to almost twice the SD for the healthy and lesion control simulations.
Positive_regulation (increased) of vmPFC in insular cortex
2) Confidence 0.58 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
These results support the hypothesis that activation of the ventral part of PFC during gum chewing evokes augmented activity of 5-HT neurons in the dorsal raphe nucleus, which in turn suppress nociceptive responses.
Positive_regulation (activation) of PFC in dorsal associated with nociception and raphe
3) Confidence 0.58 Published 2010 Journal J. Med. Dent. Sci. Section Abstract Doc Link 20437764 Disease Relevance 0.32 Pain Relevance 0.08
The present study compared the central antinociceptive effect of an inhibitor of endopeptidase 24.15, N-[1-(R-S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB) with one of endopeptidase 24.11 N-[1-(RS)-carboxy-3-phenylpropyl]-Phe-p-aminobenzoate (cFP-F-pAB) upon central opioid antinociception induced by MERGL, metenkephalin and dynorphin A1-8. cFP-AAF-pAB, but not cFP-F-pAB increased MERGL antinociception on the tail-flick and jump tests.
Positive_regulation (one) of cFP in tail associated with antinociception, dynorphin, tail-flick, opioid and antinociceptive
4) Confidence 0.49 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1349191 Disease Relevance 0.07 Pain Relevance 1.56
For our sample of healthy adults, one possible explanation for increased dmPFC activation when ignoring or attending to SBN compared to baseline is an increased awareness of external stimuli.
Positive_regulation (increased) of PFC in external
5) Confidence 0.49 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2999982 Disease Relevance 0.25 Pain Relevance 0
The combination of increased RF-PFC and decreased SBF suggests that there is defective B cell autoregulation in RA, which may be involved in the pathogenesis and chronicity of this disease.
Positive_regulation (increased) of PFC in B cell associated with rheumatoid arthritis and disease
6) Confidence 0.45 Published 1986 Journal J. Immunol. Section Abstract Doc Link 3485142 Disease Relevance 1.02 Pain Relevance 0.56
A related study showed a strong negative correlation between emotional scores and vmPFC activation in PTSD patients exposed to script-driven reminders of their traumatic experience [139] implying that impoverished vmPFC activation facilitates the return of the affect attached to the original trauma.
Positive_regulation (activation) of vmPFC associated with post-traumatic stress disorder and injury
7) Confidence 0.44 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.59 Pain Relevance 0.11
Impoverished vmPFC activation in anger patients suggests that recruitment of this region is necessary for suppression of aggressive affect.
Positive_regulation (activation) of vmPFC
8) Confidence 0.44 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.46 Pain Relevance 0.03
Using autobiographical scripts designed to evoke strong emotion, healthy control subjects showed increased blood flow in the vmPFC during script-induced anger compared to patients with anger attacks who showed an impoverished vmPFC response [131].
Positive_regulation (increased) of vmPFC in blood
9) Confidence 0.44 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.46 Pain Relevance 0.09
Interventions affecting vmPFC and insular cortex activation may have therapeutic potential in the treatment of neuropsychiatric conditions associated with abnormal decision-making.


Positive_regulation (activation) of vmPFC in insular cortex
10) Confidence 0.42 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0.14 Pain Relevance 0.05
Simulation of the vmPFC and insular cortex groupsÂ’ betting behaviour yielded moderately higher average total points, compared with simulated performance of healthy controls.
Positive_regulation (Simulation) of vmPFC in insular cortex
11) Confidence 0.42 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
Several human and animal studies have reported that a direct connection exists between the prefrontal cortex (PFC) and 5-HT neurons in the dorsal raphe nucleus; therefore, we hypothesized that activation of the PFC region might be responsible for augmented 5-HT activity.
Positive_regulation (activation) of PFC in PFC associated with raphe
12) Confidence 0.42 Published 2010 Journal J. Med. Dent. Sci. Section Abstract Doc Link 20437764 Disease Relevance 0.22 Pain Relevance 0.05
Somewhat surprisingly, PFC activation was predominantly associated with decisions made under ambiguity, which may seem incongruous with the current findings.
Positive_regulation (activation) of PFC
13) Confidence 0.39 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
Overall betting was elevated in both the vmPFC (P = 0.006, Cohen's d = 0.74) and insular cortex (P = 0.004, Cohen's d = 0.90) lesion groups compared with the pooled control group, with no difference between the vmPFC and insular cortex groups (P = 0.652, Cohen's d = 0.16).
Positive_regulation (elevated) of vmPFC in insular cortex
14) Confidence 0.39 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
Imaging studies of the Iowa Gambling Task indicate recruitment of vmPFC during decision-making under ambiguity (Fukui et al., 2005; Northoff et al., 2006; Windmann et al., 2006).
Positive_regulation (recruitment) of vmPFC associated with imagery
15) Confidence 0.39 Published 2008 Journal Brain Section Body Doc Link PMC2367692 Disease Relevance 0.14 Pain Relevance 0.12
It remains unclear whether vmPFC is also necessary for decision-making under risk, when outcome probabilities are explicit.
Spec (whether) Positive_regulation (necessary) of vmPFC
16) Confidence 0.39 Published 2008 Journal Brain Section Abstract Doc Link PMC2367692 Disease Relevance 0 Pain Relevance 0
In addition to the mPFC and PCC nodes of the DMN and their relation to the ego, we speculate on the basis of neuroimaging data and findings from deep brain stimulation (see Neuropsychiatric findings in depression correlated with principles of Freudian metapsychology below), that ventromedial PFC (vmPFC) exerts a strong repressive hold over emotional and motivational ('visceromotor') centres [50].
Positive_regulation (ventromedial) of PFC in brain associated with depression and deep brain stimulation
17) Confidence 0.32 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.75 Pain Relevance 0.24
In addition to the mPFC and PCC nodes of the DMN and their relation to the ego, we speculate on the basis of neuroimaging data and findings from deep brain stimulation (see Neuropsychiatric findings in depression correlated with principles of Freudian metapsychology below), that ventromedial PFC (vmPFC) exerts a strong repressive hold over emotional and motivational ('visceromotor') centres [50].
Positive_regulation (ventromedial) of vmPFC in brain associated with depression and deep brain stimulation
18) Confidence 0.32 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.75 Pain Relevance 0.24
A related study showed a strong negative correlation between emotional scores and vmPFC activation in PTSD patients exposed to script-driven reminders of their traumatic experience [139] implying that impoverished vmPFC activation facilitates the return of the affect attached to the original trauma.
Positive_regulation (activation) of vmPFC associated with post-traumatic stress disorder and injury
19) Confidence 0.29 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.58 Pain Relevance 0.15
Accordingly, a core theme of cognitive neuroscience research has been to parse PFC according to distinct sub-regionsÂ’ contributions to control of behavior.
Positive_regulation (parse) of PFC associated with cognitive disorder
20) Confidence 0.26 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2948450 Disease Relevance 0.21 Pain Relevance 0

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