INT744

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 130
Total Number 136
Disease Relevance 95.02
Pain Relevance 11.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 54
spine 4
plasma 3
parathyroid gland 3
hip 3
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
fibrosis 125 99.70 Very High Very High Very High
Pain 190 99.54 Very High Very High Very High
Inflammation 108 99.48 Very High Very High Very High
Dismenorea 7 99.32 Very High Very High Very High
psoriasis 8 99.28 Very High Very High Very High
spinal inflammation 10 99.02 Very High Very High Very High
chemokine 12 98.88 Very High Very High Very High
Calcium channel 6 98.72 Very High Very High Very High
backache 28 98.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoporosis 1799 99.96 Very High Very High Very High
Metastasis 184 99.96 Very High Very High Very High
Hypercalcemia 1106 99.90 Very High Very High Very High
Hypophosphatemia 20 99.88 Very High Very High Very High
Hypoxia 6 99.88 Very High Very High Very High
Cystic Fibrosis 111 99.70 Very High Very High Very High
Calcification 324 99.66 Very High Very High Very High
Arthralgia 18 99.54 Very High Very High Very High
Motor Neuron Diseases 264 99.52 Very High Very High Very High
Calciphylaxis 125 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Postoperatively the PTH level increased, though still within the normal range.
Positive_regulation (increased) of PTH
1) Confidence 0.70 Published 2000 Journal Ugeskr. Laeg. Section Abstract Doc Link 11002744 Disease Relevance 0.70 Pain Relevance 0.18
We observed an increase in PTH levels within the total study population; however, PTH levels did not differ between ethnic groups.
Positive_regulation (increase) of PTH
2) Confidence 0.70 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0 Pain Relevance 0
Subsequently an increased parathormone (PTH) level was noted (499.0 ng/l) as well as markedly increased activity of enzymes involved in bone metabolism, decreased renal excretion of phosphates (4.76 mmol/24 h) and multiple pathological fractures.
Positive_regulation (increased) of PTH
3) Confidence 0.70 Published 1999 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 10356581 Disease Relevance 0.27 Pain Relevance 0
Additional long-term use of heroin resulted in a significant increase of PTH compared to sex- and age matched controls and a second group of non-HIV-afflicted heroin dependent females.
Positive_regulation (increase) of PTH associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.70 Published 1997 Journal Eur. J. Med. Res. Section Abstract Doc Link 9262487 Disease Relevance 0.99 Pain Relevance 0.05
A persistently elevated circulating PTH level is also associated with increased bone turnover and bone loss predominantly at cortical sites and with increased risk of fractures.
Positive_regulation (elevated) of PTH
5) Confidence 0.69 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.99 Pain Relevance 0
Continual application of high concentration EDTMP could lead to a reduced level of calcium in serum and increased parathyroid hormone levels which might trigger osteoblastic activity and bone remodelling.
Positive_regulation (increased) of parathyroid hormone in parathyroid associated with osteoporosis
6) Confidence 0.69 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9608885 Disease Relevance 0.16 Pain Relevance 0
Plasma C-PTH was elevated to 22.72ng/ml.
Positive_regulation (elevated) of PTH in Plasma
7) Confidence 0.69 Published 1989 Journal Jpn. J. Med. Section Abstract Doc Link 2585894 Disease Relevance 1.20 Pain Relevance 0.09
Calcium levels were normal (2.30-2.50 mmoles) with increased PTH levels (1820 microliter Eq/ml).
Positive_regulation (increased) of PTH
8) Confidence 0.68 Published 1982 Journal Clin. Nephrol. Section Abstract Doc Link 7140028 Disease Relevance 1.37 Pain Relevance 0.09
Volumetric bone density using CT demonstrated a marked increase in the PTH alone group but combination therapy with PTH and alendronate was no different than alendronate alone.
Positive_regulation (increase) of PTH
9) Confidence 0.68 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.20 Pain Relevance 0
The Ellsworth-Howard test was performed on three patients; all had a normal phosphaturic response and an increase in urinary c'AMP to exogenous PTH.
Positive_regulation (increase) of PTH
10) Confidence 0.68 Published 1981 Journal J. Pediatr. Section Abstract Doc Link 6273518 Disease Relevance 0.49 Pain Relevance 0.08
Nifedipine, but not verapamil, acutely elevates parathyroid hormone levels in premenopausal women.
Positive_regulation (elevates) of parathyroid hormone in parathyroid
11) Confidence 0.68 Published 1995 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 7889637 Disease Relevance 0 Pain Relevance 0.42
Baseline studies revealed hypocalciuria (24 hour urine calcium less than 5 mg/day), normal serum phosphate (3.4 mg/dl), low tubular reabsorption of phosphate (68 percent), undetectable serum calcitonin, normal serum 25-hydroxyvitamin D, slightly elevated serum parathyroid hormone level and increased urinary cyclic AMP (8.87 mumol/g creatinine).
Positive_regulation (elevated) of parathyroid hormone in parathyroid
12) Confidence 0.67 Published 1981 Journal Am. J. Med. Section Abstract Doc Link 7246580 Disease Relevance 1.04 Pain Relevance 0.14
The reduced serum calcitriol in both patients and the elevated parathyroid hormone observed in the first patient before treatment returned to normal.
Positive_regulation (elevated) of parathyroid hormone in parathyroid
13) Confidence 0.67 Published 1999 Journal Am. J. Med. Sci. Section Abstract Doc Link 10408763 Disease Relevance 0.72 Pain Relevance 0.06
In children, hypercalcemia secondary to rhabdomyosarcoma is not uncommon and has been associated with bony metastasis, increased parathyroid hormone, and increased levels of prostaglandin E2.
Positive_regulation (increased) of parathyroid hormone in parathyroid associated with rhabdomyosarcoma, hypercalcemia and metastasis
14) Confidence 0.67 Published 1989 Journal Arch. Intern. Med. Section Abstract Doc Link 2719511 Disease Relevance 1.13 Pain Relevance 0.08
Three patients were hypocalcemic, 4 had elevated serum alkaline phosphatases, 5 had elevated serum immunoreactive parathyroid hormone (i-PTH) concentration and 3 had bone pains.
Positive_regulation (elevated) of PTH in parathyroid
15) Confidence 0.67 Published 1976 Journal Acta Med Scand Section Abstract Doc Link 961464 Disease Relevance 0.25 Pain Relevance 0
Intact PTH level was normal, although plasma parathyroid hormone-C (PTH-C) level increased.
Positive_regulation (increased) of parathyroid hormone in plasma
16) Confidence 0.67 Published 1996 Journal Ryumachi Section Abstract Doc Link 8779793 Disease Relevance 0.97 Pain Relevance 0.19
The intact parathyroid hormone (i-PTH) level was increased over 1,000 pg/ml and extra-osseous calcification occurred.
Positive_regulation (increased) of PTH in parathyroid associated with calcification
17) Confidence 0.67 Published 2008 Journal Clin. Nephrol. Section Abstract Doc Link 18218318 Disease Relevance 1.90 Pain Relevance 0.06
However, the serum calcium, alkaline phosphatase, and C-terminal parathyroid hormone levels remained elevated.
Positive_regulation (elevated) of parathyroid hormone in parathyroid
18) Confidence 0.67 Published 1988 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 3342577 Disease Relevance 1.02 Pain Relevance 0.17
There was a transient increase in parathyroid hormone level in 13 of the 19 patients during treatment, which was associated with a high serum 1,25 (OH)2D3.
Positive_regulation (increase) of parathyroid hormone in parathyroid
19) Confidence 0.67 Published 1979 Journal Lancet Section Abstract Doc Link 90215 Disease Relevance 0.26 Pain Relevance 0.10
All patients had extremely elevated levels of immunoreactive parathyroid hormone, and two patients had evidence of severe hyperparathyroidism on bone biopsy specimens.
Positive_regulation (elevated) of parathyroid hormone in parathyroid associated with hypercalcemia
20) Confidence 0.67 Published 1988 Journal Mayo Clin. Proc. Section Abstract Doc Link 3361954 Disease Relevance 0.33 Pain Relevance 0.10

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