INT74423

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Context Info
Confidence 0.80
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 91
Total Number 93
Disease Relevance 61.60
Pain Relevance 22.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
T cells 7
monocytes 6
blood 3
Th2 cells 3
plasma 2
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1509 100.00 Very High Very High Very High
Inflammation 1388 100.00 Very High Very High Very High
melanocortin 1 receptor 25 99.80 Very High Very High Very High
antidepressant 8 99.80 Very High Very High Very High
Central nervous system 60 99.68 Very High Very High Very High
endometriosis 182 99.60 Very High Very High Very High
Catecholamine 39 99.50 Very High Very High Very High
depression 132 99.44 Very High Very High Very High
Opioid 7 99.44 Very High Very High Very High
Osteoarthritis 31 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1759 100.00 Very High Very High Very High
Cancer 1563 99.92 Very High Very High Very High
Infection 632 99.82 Very High Very High Very High
Skin Cancer 295 99.70 Very High Very High Very High
Necrosis 103 99.68 Very High Very High Very High
Hypersensitivity 346 99.62 Very High Very High Very High
Endometriosis 238 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 155 99.60 Very High Very High Very High
Hepatitis C Virus Infection 177 99.46 Very High Very High Very High
Depression 239 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of IL-10 as a biomarker for recurrent events in ACS is complicated by the complexity of both timing and magnitude of IL-10 secretion.
Localization (secretion) of IL-10 associated with acute coronary syndrome
1) Confidence 0.80 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.44 Pain Relevance 0.06
As thoracic epidural block (TEB) should blunt the perioperative increases in cortisol and catecholamines we investigated whether IL-10 secretion is influenced by TEB.
Spec (whether) Localization (secretion) of IL-10 in thoracic associated with catecholamine and epidural
2) Confidence 0.76 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.16 Pain Relevance 0.49
Cortisol and catecholamines have been shown to be important costimulatory factors for IL-10 secretion in humans.
Localization (secretion) of IL-10 associated with catecholamine
3) Confidence 0.76 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.15 Pain Relevance 0.44
At least in cardiac surgery patients the monocyte functional depression is not related to systemic release of IL-10 and the influence of cortisol or epinephrine is less important for early monocyte deactivation than what in vitro and animal models have suggested.
Localization (release) of IL-10 in monocyte associated with depression
4) Confidence 0.76 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.43 Pain Relevance 0.37
Some probiotics act in the lumen of the gut by elaborating antibacterial molecules such as bacteriocins; others enhance the mucosal barrier by increasing the production of innate immune molecules, including goblet cell-derived mucins and trefoil factors and defensins produced by intestinal Paneth cells; and other probiotics mediate their beneficial effects by promoting adaptive immune responses (secretory immune globulin A, regulatory T cells, interleukin-10).
Localization (secretory) of interleukin-10 in lumen associated with bacterial respiratory disease
5) Confidence 0.75 Published 2009 Journal Nutr Clin Pract Section Abstract Doc Link 19244144 Disease Relevance 0.35 Pain Relevance 0.13
Seven SNPs of the genomic region of IL10, IL19, IL20, and IL24 genes (IL10 cluster) were analyzed in 153 Estonian patients with MDD and 277 healthy control subjects.
Localization (region) of IL10 associated with depression
6) Confidence 0.74 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0.24 Pain Relevance 0
Several reports describe associations between genetic variants in the IL-10 gene and increased secretion of IL-10 mRNA and protein.17–20 Of those, most studies have been restricted to the single nucleotide polymorphisms (SNP) at positions-1082 A>G, -819 C>T and -592 G>A in the IL-10 gene.
Localization (secretion) of IL-10
7) Confidence 0.70 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.79 Pain Relevance 0.16
Finally, astrocytes which release IL-10 in the central nervous system and are especially sensitive to the apoptotic effects of quinolinic acid, have been observed to be reduced in MDD [16,17].
Localization (release) of IL-10 in central nervous system associated with depression, central nervous system and apoptosis
8) Confidence 0.70 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 1.32 Pain Relevance 0.60
The TNF/IL-10 ratio, reflecting cytokine secretion by peritoneal cells, was higher in cells derived from endometriosis patients and could be further heightened by CRH stimulation, whereas stimulation with dydrogesterone abrogated the CRH-mediated inflammation.
Localization (secretion) of IL-10 associated with endometriosis, inflammation and cytokine
9) Confidence 0.68 Published 2010 Journal J. Mol. Med. Section Abstract Doc Link 19898767 Disease Relevance 1.68 Pain Relevance 0.73
An inhibitory effect on the ability of DC to mature from peripheral monocytes has been attributed to the presence of HIV-induced CD4+ CD25+ IL-10-secreting T regulatory cells (44).
Localization (secreting) of IL-10 in monocytes associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.68 Published 2006 Journal Parasite Immunology Section Body Doc Link PMC1636681 Disease Relevance 0.93 Pain Relevance 0
Taking into account the present data, this would argue in favour of stimulating the joints of patients with early OA, or patients at high risk of developing OA, with exercise, as this would result in a release of IL-10, a response that potentially could have beneficial effects upon the control of the immune response.
Localization (release) of IL-10 in joints associated with osteoarthritis
11) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945016 Disease Relevance 0.91 Pain Relevance 0.32
RESULTS: We found that the H. pylori-specific response consists of both T helper 1 and 2 subsets with high levels of IL10-secreting Tregs.
Localization (secreting) of IL10-secreting
12) Confidence 0.59 Published 2008 Journal Gut Section Body Doc Link 18467372 Disease Relevance 0 Pain Relevance 0
The model also predicted that the anti-inflammatory mediator, IL-10, would be secreted in great quantities by wound macrophages during the first 5 days post-injury.
Localization (secreted) of IL-10 in macrophages associated with inflammation and injury
13) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 1.19 Pain Relevance 0.37
Although donor and CP PBMC responded equally to LPS, PACAP-mediated counteraction of LPS-induced cytokine response was switched from inhibiting TNF-alpha to decreasing IL-1beta and increasing IL-10 secretion.
Localization (secretion) of IL-10 in PBMC associated with chronic pancreatitis and cytokine
14) Confidence 0.57 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 1.11 Pain Relevance 0.98
The aim of the present study was to investigate if choice of anaesthesia, based on high-dose opioids (fentanyl) versus low-dose opioids influenced the release of IL-6, IL-8, and IL-10.
Localization (release) of IL-10 associated with opioid
15) Confidence 0.55 Published 1998 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9527747 Disease Relevance 0.32 Pain Relevance 0.65
The secretion of human TNF-alpha, IL-10, IL-8 and IL-1beta from THP-1 cells attached to the IPNs was measured to assess the concentration of both pro- and anti-inflammatory cytokines.
Localization (secretion) of IL-10 in THP-1 associated with inflammation and cytokine
16) Confidence 0.54 Published 2008 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 18854128 Disease Relevance 0.37 Pain Relevance 0.53
The anti-inflammatory mediator IL-10 was predicted to be secreted rapidly after the 4-hr treatment and remain elevated up to Day 3 post-injury.
Localization (secreted) of IL-10 associated with inflammation and injury
17) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 1.10 Pain Relevance 0.33
However, we know that the release of the anti-inflammatory cytokines IL-10 and transforming growth factor (TGF)-?
Localization (release) of IL-10 associated with inflammation and cytokine
18) Confidence 0.50 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 0.95 Pain Relevance 0.33
Moreover, antidepressants increase secretion of IL-10 [67].
Localization (secretion) of IL-10 associated with antidepressant
19) Confidence 0.50 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.01 Pain Relevance 0.77
This is in line with data showing inhibition of intervillous blood mononuclear cells (IVBMCs) charged in HZ and in particular suppression of PGE2, TNF, and IL-10 secretion [33,34].
Localization (secretion) of IL-10 in blood
20) Confidence 0.50 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 0.66 Pain Relevance 0.08

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