INT74425

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Context Info
Confidence 0.08
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.81
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hepatocytes 2
precursor cell 1
granulocyte 1
hip 1
neurons 1
SPHAR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 39 99.60 Very High Very High Very High
Inflammation 53 99.40 Very High Very High Very High
rheumatoid arthritis 57 99.32 Very High Very High Very High
Osteoarthritis 29 98.84 Very High Very High Very High
Inflammatory response 5 94.48 High High
anesthesia 2 94.48 High High
Opioid 5 93.36 High High
imagery 29 93.12 High High
Angina 2 79.96 Quite High
tolerance 1 59.12 Quite High
Disease Link Frequency Relevance Heat
Injury 12 99.64 Very High Very High Very High
INFLAMMATION 61 99.40 Very High Very High Very High
Rheumatoid Arthritis 57 99.32 Very High Very High Very High
Frailty 33 98.84 Very High Very High Very High
Delirium 43 98.38 Very High Very High Very High
Infection 11 98.20 Very High Very High Very High
Respiratory Syncytial Virus 25 97.04 Very High Very High Very High
Brain Injury 28 96.88 Very High Very High Very High
Cancer 8 96.52 Very High Very High Very High
Agranulocytosis 2 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proinflammatory cytokines are potent inducers of the hepatic acute-phase protein synthesis.
Gene_expression (synthesis) of acute-phase protein associated with cytokine
1) Confidence 0.08 Published 1998 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9527747 Disease Relevance 0.35 Pain Relevance 0.66
A similar effect was observed for haptoglobin mRNA, used as a control for acute-phase protein expression.
Gene_expression (expression) of acute-phase protein
2) Confidence 0.05 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.16 Pain Relevance 0.13
Therefore, we aimed to determine whether PSP/reg is an acute-phase protein after nonpancreatic trauma.
Spec (whether) Gene_expression (/) of acute-phase protein in PSP associated with injury
3) Confidence 0.05 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.36 Pain Relevance 0.09
If the appearance of the S-phase cyclin, cyclin A, is used as a marker there is a significant cell cycle involvement of the neurons of the deep cerebellar nuclei in AD cases compared to controls.
Gene_expression (appearance) of S-phase cyclin in neurons associated with disease
4) Confidence 0.05 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.95 Pain Relevance 0
CRP is an acute-phase protein that is produced in large amounts by hepatocytes, upon stimulation by the cytokines interleukin (IL)6, tumor necrosis factor ?
Gene_expression (produced) of acute-phase protein in hepatocytes associated with necrosis, cancer and cytokine
5) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 1.57 Pain Relevance 0.59
Lending support to the hypothesis that acute inflammation leads to brain injury and subsequent development of delirium, a recent study found that delirium in postoperative hip-fractured patients was significantly associated with serum levels of C-reactive protein, an acute-phase protein that is a marker of acute inflammation [55].
Gene_expression (levels) of acute-phase protein in hip associated with inflammation, delirium and brain injury
6) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1794449 Disease Relevance 2.29 Pain Relevance 0.14
C-reactive protein (CRP) is an acute-phase protein that is predominantly synthesized by hepatocytes in response to inflammation, infection, and tissue damage [3, 4].
Gene_expression (synthesized) of acute-phase protein in hepatocytes associated with inflammation and infection
7) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 1.28 Pain Relevance 0.21
IL-6 is involved in hepatic acute-phase protein synthesis and stimulation of hematopoietic precursor cell proliferation and differentiation.
Gene_expression (synthesis) of acute-phase protein in precursor cell
8) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.21 Pain Relevance 0.18
It is well documented that different types of extracorporeal

circulation, such as haemodialysis using cuprophane membranes and cardiopulmonary bypass (CPB), are associated with complement activation [1,2]; granulocytopenia followed by granulocytosis [3], granulocyte activation and degranulation [3,4]; increased production of proinflammatory and anti-inflammatory cytokines; and increased acute-phase protein synthesis [5,6].

Gene_expression (synthesis) of acute-phase protein in granulocyte associated with agranulocytosis, inflammation and cytokine
9) Confidence 0.01 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.63 Pain Relevance 0.15

General Comments

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