INT74433

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Context Info
Confidence 0.03
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS, Cpe) peptidase activity (Cpe) small molecule metabolic process (INS)
extracellular region (INS) Golgi apparatus (Cpe) carbohydrate metabolic process (INS)
Anatomy Link Frequency
pituitary 1
INS (Homo sapiens)
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the sorting of proinsulin and proenkephalin to the RSP, like POMC, necessitates binding to CPE, and hence, CPE acts as a common sorting receptor for targeting these prohormones to the RSP.
proinsulin Binding (binding) of CPE
1) Confidence 0.03 Published 1998 Journal Endocrinology Section Abstract Doc Link 9529003 Disease Relevance 0 Pain Relevance 0
The binding of pro-opiomelanocortin,(POMC), pro-insulin, pro-enkephalin and chromogranin A (CGA) to the regulated secretory pathway sorting receptor, carboxypeptidase E (CPE), in bovine pituitary secretory granule (SG) membranes was investigated.
pro-insulin Binding (binding) of carboxypeptidase E in pituitary associated with enkephalin
2) Confidence 0.00 Published 1998 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9705069 Disease Relevance 0 Pain Relevance 0.25

General Comments

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