INT74447

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Context Info
Confidence 0.76
First Reported 1998
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 39
Total Number 43
Disease Relevance 21.96
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf)
Anatomy Link Frequency
plasma 7
endothelial cells 5
platelet 3
vessels 2
liver 1
Vwf (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 14 99.68 Very High Very High Very High
rheumatoid arthritis 133 99.56 Very High Very High Very High
Paracetamol 17 97.56 Very High Very High Very High
Restless leg syndrome 6 96.88 Very High Very High Very High
Inflammation 258 95.40 Very High Very High Very High
medulla 56 94.96 High High
ischemia 44 94.72 High High
cytokine 102 91.92 High High
agonist 4 91.80 High High
fibrosis 15 88.68 High High
Disease Link Frequency Relevance Heat
Adhesions 90 100.00 Very High Very High Very High
Reperfusion Injury 5 99.92 Very High Very High Very High
Disorder Of Lipid Metabolism 554 99.74 Very High Very High Very High
Ankylosing Spondylitis 14 99.68 Very High Very High Very High
Cv Unclassified Under Development 21 99.64 Very High Very High Very High
Rheumatoid Arthritis 135 99.56 Very High Very High Very High
Targeted Disruption 293 99.54 Very High Very High Very High
Hypoxia 5 99.16 Very High Very High Very High
Disease 195 99.12 Very High Very High Very High
Cancer 82 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
vWf is synthesized as a large, 360-kDa precursor, pro-vWf, which is cleaved into mature vWf and a 97-kDa propeptide [15].
Gene_expression (synthesized) of vWf
1) Confidence 0.76 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.96 Pain Relevance 0.17
vWf is synthesized as a large, 360-kDa precursor, pro-vWf, which is cleaved into mature vWf and a 97-kDa propeptide [15].
Gene_expression (synthesized) of vWf
2) Confidence 0.66 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.91 Pain Relevance 0.17
These results indicate that the propeptide concentrations might be more useful than vWf in the assessment of disease activity in patients with SSc.


Gene_expression (useful) of vWf associated with systemic sclerosis and disease
3) Confidence 0.66 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.47 Pain Relevance 0.03
In an earlier study [32], we found an inverse correlation between the glomerular filtration rate and vWf and a negative relation between pulmonary pressure and vWf in a small number of patients with isolated pulmonary hypertension.
Gene_expression (pressure) of vWf associated with hypertension
4) Confidence 0.66 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.70 Pain Relevance 0.04
The results showed both sulindac and celecoxib decreased the micro-vessel density (MVD), which was labeled by either CD34 or VWF staining, within xenografts.
Gene_expression (staining) of VWF
5) Confidence 0.65 Published 2005 Journal Biomed. Pharmacother. Section Abstract Doc Link 16507395 Disease Relevance 0.59 Pain Relevance 0.24
In an earlier study [32], we found an inverse correlation between the glomerular filtration rate and vWf and a negative relation between pulmonary pressure and vWf in a small number of patients with isolated pulmonary hypertension.
Gene_expression (pressure) of vWf associated with hypertension
6) Confidence 0.57 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.59 Pain Relevance 0.04
The vascular endothelial cells (ECs) express various antigens related to coagulation factors, including factor VIII-related antigen or von Willebrand factor (vWF) in the cytoplasm and thrombomodulin (TM; a thrombin receptor)along the plasma membrane.
Gene_expression (express) of vWF in plasma
7) Confidence 0.57 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16415510 Disease Relevance 0 Pain Relevance 0.06
Immunohistochemistry experiments with the liver tissue showed that the donor-derived cells expressed the markers of both hepatocytes (albumin and cytokeratin-18) and endothelial cells (von Willebrand factor).
Gene_expression (expressed) of von Willebrand factor in liver
8) Confidence 0.57 Published 2009 Journal Blood Section Abstract Doc Link 19752394 Disease Relevance 0.33 Pain Relevance 0.09
This was additionally emphasized by the staining for the endothelial markers von Willebrand Factor (vWF) and platelet endothelial cell adhesion molecule-1 (PECAM or CD31), which appeared to be expressed largely by GFP- cells (Figure 3B, C).


Gene_expression (expressed) of vWF in platelet associated with adhesions
9) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.10 Pain Relevance 0
Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).
Gene_expression (levels) of vWF in Plasma associated with paracetamol and cytokine
10) Confidence 0.51 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.24 Pain Relevance 0.64
Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).
Gene_expression (levels) of von Willebrand factor in Plasma associated with paracetamol and cytokine
11) Confidence 0.51 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.24 Pain Relevance 0.64
In search for the signs of BBB damage in the brain of symptomatic A53T mice, we examined the expression and subcellular distribution of aquaporin 4, glucose transporter 1 (Glut1) and von Willebrand factor (vWF) in astrocyte and vascular endothelial cells.
Spec (examined) Gene_expression (expression) of vWF in endothelial cells associated with targeted disruption
12) Confidence 0.49 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.46 Pain Relevance 0.27
In search for the signs of BBB damage in the brain of symptomatic A53T mice, we examined the expression and subcellular distribution of aquaporin 4, glucose transporter 1 (Glut1) and von Willebrand factor (vWF) in astrocyte and vascular endothelial cells.
Spec (examined) Gene_expression (expression) of von Willebrand factor in endothelial cells associated with targeted disruption
13) Confidence 0.49 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.46 Pain Relevance 0.27
Von Willebrand factor (vWF) is another protein expressed by endothelial cells that plays an essential role in platelet adhesion and aggregation; the circulating vWF levels are inversely correlated with plasma HDL (Conlan et al 1993), suggesting that HDL may inhibit vWF production.
Gene_expression (expressed) of vWF in platelet associated with disorder of lipid metabolism and adhesions
14) Confidence 0.42 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.29 Pain Relevance 0.05
Von Willebrand factor (vWF) is another protein expressed by endothelial cells that plays an essential role in platelet adhesion and aggregation; the circulating vWF levels are inversely correlated with plasma HDL (Conlan et al 1993), suggesting that HDL may inhibit vWF production.
Gene_expression (expressed) of Von Willebrand factor in platelet associated with disorder of lipid metabolism and adhesions
15) Confidence 0.42 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.30 Pain Relevance 0.05
Von Willebrand factor (vWF) is another protein expressed by endothelial cells that plays an essential role in platelet adhesion and aggregation; the circulating vWF levels are inversely correlated with plasma HDL (Conlan et al 1993), suggesting that HDL may inhibit vWF production.
Gene_expression (production) of vWF in plasma associated with disorder of lipid metabolism and adhesions
16) Confidence 0.42 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.23 Pain Relevance 0.04
Similarly, we find no clear evidence of co-expression of GFP and vWF/CD31, although such co-expression has been previously reported at later times of observation (3 days – 1 month) after induction of ischemia [38,50].


Gene_expression (expression) of vWF associated with ischemia
17) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.30 Pain Relevance 0.08
There were also significantly higher CRP, IL-6, fibrinogen, and von Willebrand factor levels in the AS group.
Gene_expression (levels) of von Willebrand factor associated with spinal inflammation
18) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.95 Pain Relevance 0.52
Von Willebrand factor (vWF) is another protein expressed by endothelial cells that plays an essential role in platelet adhesion and aggregation; the circulating vWF levels are inversely correlated with plasma HDL (Conlan et al 1993), suggesting that HDL may inhibit vWF production.
Gene_expression (levels) of vWF in plasma associated with disorder of lipid metabolism and adhesions
19) Confidence 0.36 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.27 Pain Relevance 0.04
IHC revealed LacZ+ cells co-expressing Sca, CD31, CD45, vWF, and ?
Gene_expression (co-expressing) of vWF
20) Confidence 0.30 Published 2010 Journal Basic Res Cardiol Section Abstract Doc Link PMC2916122 Disease Relevance 0.60 Pain Relevance 0

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