INT74449

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Context Info
Confidence 0.30
First Reported 1998
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 53
Total Number 57
Disease Relevance 34.49
Pain Relevance 14.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B4GALNT1) plasma membrane (B4GALNT1) carbohydrate metabolic process (B4GALNT1)
Anatomy Link Frequency
plaques 2
vessels 2
lung 2
microglia 2
leukocyte 2
B4GALNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Osteoarthritis 50 99.76 Very High Very High Very High
metalloproteinase 10 99.76 Very High Very High Very High
Pain 20 99.74 Very High Very High Very High
Migraine 6 99.74 Very High Very High Very High
COX2 12 99.64 Very High Very High Very High
GABAergic 10 99.44 Very High Very High Very High
Morphine 29 99.36 Very High Very High Very High
cytokine 254 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 8 99.82 Very High Very High Very High
Apoptosis 146 99.76 Very High Very High Very High
Osteoarthritis 52 99.76 Very High Very High Very High
Headache 7 99.74 Very High Very High Very High
Increased Venous Pressure Under Development 59 99.72 Very High Very High Very High
Necrosis 30 99.70 Very High Very High Very High
Asthma 138 99.64 Very High Very High Very High
Atherosclerotic Plaque 10 99.62 Very High Very High Very High
Cancer 35 99.52 Very High Very High Very High
INFLAMMATION 463 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated nitric oxide production derived from NO synthase activity has been manifested in cerebrospinal fluid in patients with degenerative lumbar disease.
Positive_regulation (derived) of NO synthase in cerebrospinal fluid associated with disease
1) Confidence 0.30 Published 2007 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 17543240 Disease Relevance 1.29 Pain Relevance 0.33
Although the presence of neuronal nitric oxide synthase (nNOS) has been demonstrated in human clitoral corpus cavernosum, functional evidence for the nitrergic neurotransmission as a nonadrenergic noncholinergic (NANC) transmitter has been limited to animal studies.
Positive_regulation (presence) of synthase in neuronal associated with neuronal nitric oxide synthase
2) Confidence 0.20 Published 2004 Journal Int. J. Impot. Res. Section Abstract Doc Link 14961056 Disease Relevance 0 Pain Relevance 0.11
This increase in blood flow and shear stress associated with dynamic exercise augments endothelial function by increasing NO synthase, leading to reduced arterial stiffness observed in previous studies [8, 9].
Positive_regulation (increasing) of NO synthase in blood associated with stress
3) Confidence 0.18 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570577 Disease Relevance 1.10 Pain Relevance 0.06
This division of GABAergic interneurons into distinct subpopulations of neuropeptide or NO synthase containing cells is consistent with and provides an anatomical correlate for the pharmacology of these transmitters and the pattern of transmitter release during reflex peristalsis.
Positive_regulation (subpopulations) of NO synthase in interneurons associated with gabaergic and neuropeptide
4) Confidence 0.18 Published 1998 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 9531443 Disease Relevance 0 Pain Relevance 0.85
Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction.
Positive_regulation (inducible) of NO synthase
5) Confidence 0.13 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.08 Pain Relevance 0
With respect to the current literature and the clinical findings it is discussed that both increased leukocyte/endothelial cell adhesion and altered release of reactive oxygen species or inducible nitric oxide synthase (iNOS) may play a role in 5-FU-induced colitis.
Positive_regulation (inducible) of synthase in endothelial cell
6) Confidence 0.10 Published 2007 Journal Strahlenther Onkol Section Body Doc Link 17680227 Disease Relevance 0.08 Pain Relevance 0
Since the effect of NMDA receptor activation and the associated Ca2+ influx results in production of nitric oxide (NO) by activation of NO synthase, it seems that spinal NO also plays an important role in nociception evoked by i.t. high-dose morphine.
Positive_regulation (activation) of synthase in spinal associated with nociception, nmda receptor and morphine
7) Confidence 0.09 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936820 Disease Relevance 0.75 Pain Relevance 1.76
Follicular fluid NO seems to be produced by either endothelial NO synthase or induced NO synthase.
Neg (NO) Positive_regulation (induced) of synthase
8) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.15 Pain Relevance 0.03
In pathological conditions, inducible NO synthase might play a major role in NO production.
Neg (NO) Positive_regulation (inducible) of synthase
9) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.24 Pain Relevance 0.09
Prior naloxone (10(-6) M) or N-nitro-L-arginine methyl ester (L-NAME) (10(-4) M) addition abrogated morphine's down-regulating activity, demonstrating morphine was initiating its actions via stimulating constitutive NO synthase derived NO release via the mu3 opiate receptor splice variant.
Positive_regulation (stimulating) of NO synthase associated with narcan, opiate and morphine
10) Confidence 0.08 Published 2008 Journal Addict Biol Section Abstract Doc Link 17573783 Disease Relevance 0 Pain Relevance 1.11
Moreover, accumulation of a marker of protein nitration nitrotyrosine, as well as the superoxide anion (O(2)(-)) levels and inducible nitric oxide synthase (iNOS), were evaluated.
Positive_regulation (inducible) of synthase
11) Confidence 0.08 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.23 Pain Relevance 0.35
In the present study, we report that administration of double-stranded RNA, a classical inducer of interferon-gamma (IFN-gamma), causes rapid and persistent activation of microglia and astrocytes, as well as induction of interleukin-1beta (IL-beta) and nitric oxide synthase.
Positive_regulation (induction) of synthase in astrocytes
12) Confidence 0.06 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 1.03 Pain Relevance 0.30
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Positive_regulation (inducible) of synthase in chondrocytes associated with osteoarthritis
13) Confidence 0.06 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.24
Our data shows that the pamidronate treatment provoked a significant increase in the [Ca2+](i) parallel to the enhancement in NO release, suggesting a possible activation of constitutive nitric oxide synthase, while the myeloperoxidase activity was significantly reduced.
Spec (possible) Positive_regulation (activation) of synthase
14) Confidence 0.06 Published 2009 Journal Cell. Mol. Biol. Lett. Section Abstract Doc Link 19238333 Disease Relevance 0.38 Pain Relevance 0.22
Inducible NO synthase is activated by cytokines such as, interleukin-1, and TNF-?
Positive_regulation (Inducible) of synthase associated with cytokine
15) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.44 Pain Relevance 0.12
Inducible NO synthase (iNOS) is present in mononuclear phagocytes (monocytes and macrophages) and produces a large amount of NO.
Positive_regulation (Inducible) of synthase in monocytes
16) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.56 Pain Relevance 0.14
In most organs, inducible NO synthase is expressed only in response to immunological stimuli [29].

1.4 Antioxidants

Neg (NO) Positive_regulation (inducible) of synthase
17) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.22 Pain Relevance 0.09
Moreover, accumulation of a marker of protein nitration nitrotyrosine, as well as the superoxide anion (O(2)(-)) levels and inducible nitric oxide synthase (iNOS), were evaluated.
Positive_regulation (inducible) of synthase
18) Confidence 0.06 Published 2004 Journal Diabetes Section Abstract Doc Link 15331549 Disease Relevance 1.23 Pain Relevance 0.35
The results suggest that phentolamine relaxes HCC by a nonadrenergic-noncholinergic mechanism dependent on nitric oxide synthase activity and activation of K(ATP)-channel.
Positive_regulation (activation) of synthase
19) Confidence 0.05 Published 2005 Journal Int. J. Impot. Res. Section Abstract Doc Link 15510188 Disease Relevance 0 Pain Relevance 0.09
The present studies demonstrate that histamine is likely to activate NO synthase to promote NO production.
Spec (likely) Positive_regulation (activate) of NO synthase
20) Confidence 0.05 Published 2002 Journal Brain Res. Section Abstract Doc Link 12426051 Disease Relevance 0.15 Pain Relevance 0.33

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