INT74467

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1998
Last Reported 1998
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1, Gh1) signal transduction (Adcyap1, Gh1) extracellular space (Adcyap1, Gh1)
extracellular region (Adcyap1, Gh1) mitochondrion (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
anterior pituitary 4
Adcyap1 (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 12 99.72 Very High Very High Very High
sodium channel 4 75.00 Quite High
Neuropeptide 4 25.00 Low Low

|}

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tetrodotoxin (TTX) blunted the GH release induced by PACAP-38 but not by GRH.
PACAP-38 Neg (not) Positive_regulation (induced) of Localization (release) of GH associated with tetrodotoxin
1) Confidence 0.37 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9533816 Disease Relevance 0 Pain Relevance 0.32
Both pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and growth hormone-releasing hormone (GRH) stimulated growth hormone (GH) release from perfused rat anterior pituitary cells.
pituitary adenylate cyclase-activating polypeptide-38 Positive_regulation (stimulated) of Localization (release) of GH in anterior pituitary
2) Confidence 0.32 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9533816 Disease Relevance 0 Pain Relevance 0.31
Both pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and growth hormone-releasing hormone (GRH) stimulated growth hormone (GH) release from perfused rat anterior pituitary cells.
PACAP-38 Positive_regulation (stimulated) of Localization (release) of GH in anterior pituitary
3) Confidence 0.22 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9533816 Disease Relevance 0 Pain Relevance 0.31
These results suggest an involvement of TTX-sensitive Na+ channels but not Ca2+-activated nonselective cation channels in PACAP-38-induced GH secretion, and that post-receptor mechanisms for PACAP-38 are different from those activated by GRH.
PACAP-38 Neg (not) Positive_regulation (induced) of Localization (secretion) of GH associated with tetrodotoxin
4) Confidence 0.22 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9533816 Disease Relevance 0 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox