INT74482

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Context Info
Confidence 0.20
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam7) plasma membrane (Adam7)
Anatomy Link Frequency
thalamus 1
Adam7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 6 100.00 Very High Very High Very High
Serotonin 4 99.68 Very High Very High Very High
fluoxetine 2 99.12 Very High Very High Very High
positron emission tomography 6 85.92 High High
imagery 4 79.84 Quite High
Inflammation 6 50.00 Quite Low
narcan 1 10.00 Low Low
Endogenous opioid 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 50.00 Quite Low
Injury 2 28.96 Quite Low
Blister 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The [(11)C]SMe-ADAM uptake in the thalamus was significantly decreased by pretreatment with fluoxetine to 38 +/- 11% of the control value.
Negative_regulation (decreased) of SMe-ADAM in thalamus associated with thalamus and fluoxetine
1) Confidence 0.20 Published 2006 Journal Nucl. Med. Biol. Section Abstract Doc Link 16459259 Disease Relevance 0 Pain Relevance 0.52
N,N-Dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (SMe-ADAM, 1) is a highly potent and selective inhibitor of the serotonin transporter (SERT).
Negative_regulation (inhibitor) of SMe-ADAM associated with serotonin
2) Confidence 0.20 Published 2006 Journal Nucl. Med. Biol. Section Abstract Doc Link 16459259 Disease Relevance 0 Pain Relevance 0.24
Evidence is also provided that the modulatory inhibitory effect of hemorphin-7 is mediated via activation of opioid receptor(s).
Negative_regulation (effect) of hemorphin-7
3) Confidence 0.07 Published 1998 Journal Inflamm. Res. Section Body Doc Link 9535541 Disease Relevance 0 Pain Relevance 0

General Comments

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