INT74485

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn9a) transmembrane transport (Scn9a)
Anatomy Link Frequency
stage 4 1
Scn9a (Mus musculus)
Scn9a - N641Y (1)
Pain Link Frequency Relevance Heat
sodium channel 9 100.00 Very High Very High Very High
tetrodotoxin 1 71.36 Quite High
lidocaine 1 70.68 Quite High
Neuropeptide 2 12.80 Low Low
Nav1.7 20 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Paroxysmal extreme pain disorder 14 5.00 Very Low Very Low Very Low
primary erythermalgia 10 5.00 Very Low Very Low Very Low
anticonvulsant 6 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 144 98.92 Very High Very High Very High
Febrile Convulsions 120 50.00 Quite Low
Epilepsy 44 50.00 Quite Low
Death 2 23.48 Low Low
Syndrome 92 5.00 Very Low Very Low Very Low
Disease 30 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Partial Seizures 14 5.00 Very Low Very Low Very Low
Somatoform Disorder 14 5.00 Very Low Very Low Very Low
Erythermalgia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a separate test to evaluate seizure susceptibility, the rate of kindling acquisition was evaluated in Scn9a-N641Y knockin mice.
Positive_regulation (evaluated) of Scn9a-N641Y (N641Y) associated with convulsion
1) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.38 Pain Relevance 0
Male N5F2 P69–P164 Scn9a knockin littermate mice were stimulated twice daily with a subthreshold 3mA corneal stimulation for 3 seconds until they reached a stably kindled state, defined as four consecutive secondarily generalized seizures (Racine stage 4–5) [35].
Positive_regulation (stimulated) of Scn9a in stage 4 associated with convulsion
2) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.44 Pain Relevance 0
A putative voltage-gated sodium channel alpha subunit (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus: structural comparisons and evolutionary considerations.
Positive_regulation (voltage-gated) of voltage-gated sodium channel alpha subunit associated with sodium channel
3) Confidence 0.11 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9535741 Disease Relevance 0 Pain Relevance 0.19

General Comments

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