INT74486

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.00
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN1A) transmembrane transport (SCN1A)
Anatomy Link Frequency
hippocampus 1
SCN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 16 100.00 Very High Very High Very High
Nav1.1 10 100.00 Very High Very High Very High
nav1.3 8 100.00 Very High Very High Very High
Hippocampus 6 99.68 Very High Very High Very High
tetrodotoxin 10 99.44 Very High Very High Very High
Nav1.2 5 98.16 Very High Very High Very High
Nav1.6 7 94.56 High High
Nav1.7 7 93.20 High High
nav1.8 9 74.56 Quite High
Action potential 1 74.56 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 4 98.52 Very High Very High Very High
Convulsion 4 94.48 High High
Fever 1 93.60 High High
Myoclonic Epilepsies 2 91.28 High High
Generalized Epilepsy 1 87.80 High High
Febrile Convulsions 1 86.76 High High
Sperm Disorder 15 20.24 Low Low
Pain 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat.
Positive_regulation (up-regulated) of Nav1.1 in hippocampus associated with epilepsy, nav1.3, nav1.1, sodium channel and hippocampus
1) Confidence 0.67 Published 2008 Journal Brain Res. Bull. Section Title Doc Link 18158113 Disease Relevance 0.64 Pain Relevance 0.67
subunits are inhibited by TTX in the nanomolar range and include SCN1A (also known as Nav1.1), SCN2A (also known as Nav1.2), SCN3A (also known as Nav1.3), SCN4A (also known as Nav1.4), SCN8A (also known as Nav1.6), and SCN9A (also known as Nav1.7).
Positive_regulation (include) of SCN1A associated with nav1.3, tetrodotoxin, nav1.1, nav1.2, nav1.7 and nav1.6
2) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.26
Nonsense, frameshift, and missense mutations of SCN1A gene encoding the voltage-gated Na(+) channel alpha-subunit type I (Na(v)1.1) have been identified in patients with SMEI.
Positive_regulation (voltage-gated) of alpha-subunit type I
3) Confidence 0.44 Published 2003 Journal Epilepsy Res. Section Abstract Doc Link 12837571 Disease Relevance 0.35 Pain Relevance 0.07
A putative voltage-gated sodium channel alpha subunit (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus: structural comparisons and evolutionary considerations.
Positive_regulation (voltage-gated) of PpSCN1 associated with sodium channel
4) Confidence 0.02 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9535741 Disease Relevance 0 Pain Relevance 0.19

General Comments

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